Plasma d-Dimer as a Useful Marker Predicts Severity of Atherosclerotic Lesion and Short-Term Outcome in Patients With Coronary Artery Disease

Abstract

Increased d-dimer is indicative of a hypercoagulable state and found to be associated with acute coronary syndromes. The present study aimed to evaluate whether plasma d-dimer levels could predict subsequent major clinical events in patients with coronary artery disease (CAD). First, 2209 angiographic-proven patients with CAD were consecutively enrolled. Then, all patients were subjected to follow up for an average of 18 months (ranged from 14 to 1037 days). The relationships of the plasma d-dimer with the severity of CAD and future clinical outcomes were evaluated. We found that plasma d-dimer was higher in patients with prior myocardial infarction (MI) than that in patients with nonprior MI (P = .006). Multivariate linear regression analysis suggested that the plasma d-dimer was linked to the severity of CAD assessed by Gensini score (β = 0.052, 95% confidence interval [CI]: 1.20-6.84, P = .005) even after adjusting for confounding factors. During the follow-up, 42 patients underwent prespecified outcomes. After adjustment for multiple variables in the Cox regression model, the d-dimer levels remained to be a potential predictor of total outcome (hazard ratio = 1.22, 95% CI: 1.09-1.37, P = .001). Therefore, plasma d-dimer levels appeared to be a useful predictor for the severity of CAD and the subsequent major clinical events.

Prognostic Value of Combination of Plasma D-Dimer Concentration and Estimated Glomerular Filtration Rate in Predicting Long-Term Mortality of Patients With Stable Coronary Artery Disease

“…Therefore, we did not evaluate whether D-dimer levels could function as a monitoring marker and whether improvements in this biomarker would affect the ful predictor of major adverse cardiovascular events in patients with stable CAD. 7 The mean follow-up period of their study was shorter than in our study (18 vs. 73 month, respectively).…”

Relationship Between D-Dimer / Creatinine Ratio and Coronary Artery Disease Severity in Patients with ST-Segment Elevation Myocardial Infarction

“…It has also been suggested that D-dimer may be an independent predictor of 2-year mortality after percutaneous coronary intervention in patients with coronary artery diseas [22]. D-dimer has also been shown to correlate with coronary SYNTAX II score and Gensini score in patients with coronary heart disease [4,23]. Creatinine is a metabolite of creatine, which is released during dephosphorylation to form creatinine and is excreted in the form of urine.…”

“…Results based on a prospective community-based atherosclerosis risk in communities study showed that people with high serum creatinine levels had an increased risk of coronary heart disease [26]. Serum creatinine levels have been shown to be an independent predictor of the severity and short-term outcome in patients with coronary artery disease [23,27,28].…”

Change Trend of Plasma D-Dimer Level and Its Clinical Value in Patients with Acute Lower Limb Ischemia Treated by Catheter-Directed Thrombolysis

“…D-dimer is considered a useful biomarker because of its potential to identify individuals in a high coagulation state. D-dimer is often associated with thrombi, and its elevation should be of continuing concern [13][14][15] . D-dimer has been widely used in the diagnosis of VTE 8,16,17 .…”