Plasma Soluble Fibrin Monomer Complex as a Marker of Coronary Thrombotic Events in Patients with Acute Myocardial Infarction

The Role of Serum D-Dimer Level in the Diagnosis of Patients Admitted to the Emergency Department Complaining of Chest Pain

“…Markers that reflect the obstructive events in the coronary arteries would be more useful than those reflecting the damage to myocardial muscles. 23 Elevated D-dimer concentrations may reflect a systemic prothrombotic state and, possibly, focal vessel-wall related fibrin formation and degradation associated with unstable atherosclerotic plaque activity. 24 Ieko et al 23 showed that D-dimer and plasmin-plasmin inhibitor complex levels in the acute phase of ACS were significantly higher than those in the recovery phase, suggesting intracoronary thrombosis.…”

“…23 Elevated D-dimer concentrations may reflect a systemic prothrombotic state and, possibly, focal vessel-wall related fibrin formation and degradation associated with unstable atherosclerotic plaque activity. 24 Ieko et al 23 showed that D-dimer and plasmin-plasmin inhibitor complex levels in the acute phase of ACS were significantly higher than those in the recovery phase, suggesting intracoronary thrombosis. Specifically, D-dimer concentrations were increased in the peripheral blood of patients with USAP, without overlap with levels in patients with stable angina.…”

Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment: 2017 Appendix on Anticoagulants Including Direct Oral Anticoagulants

“…Additionally, thrombotic markers including soluble fibrin (SF) or fibrin monomer complex (FMC) can be used to determine the therapeutic effects of anticoagulants and evaluate the risk of thrombus formation (Table ). Soluble fibrin responds more quickly to postoperative deep venous thrombosis than D‐dimer and is a good thrombotic marker for accurately predicting the risk of coronary thrombosis . Furthermore, because its half‐life ranges from 8 h to 11 h, it can be a good marker for assessing the effect of DOAC.…”

“…CHADS 2 (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stoke [double weight]) scores correlate with a risk of brain infarction in patients with non‐valvular atrial fibrillation, and they are useful for assessing the clinical risk of thrombosis. Recently, soluble fibrin (SF and FMC) has also attracted attention as a coagulation system molecular marker that reflects hypercoagulation and predicts thrombosis and a pre‐thrombotic state . Thrombus formation may tend to occur when patients have many clinical risk factors or a high level of soluble fibrin or when their soluble fibrin levels increase during withdrawal, and withdrawal of anticoagulants requires particular attention.…”

Use of fibrin monomer complex for screening for venous thromboembolism in the late pregnancy and post‐partum period

“…However, these markers have high rates of false‐positive results during pregnancy and the post‐partum period due to the presence of a hypercoagulable state. A blood coagulation marker that has been recently attracting attention is the fibrin monomer complex (FMC), which has been studied for its usefulness in the early diagnoses of orthopedic and cardiovascular diseases . This marker has also been suggested to be useful during pregnancy because its levels typically do not vary extensively during a normal pregnancy …”