Plasma Steroid-Binding Proteins

Rosner, William

doi:10.1016/s0889-8529(18)30240-8

Cited by 166 publications

(102 citation statements)

References 130 publications

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“…Sibutramine treatment resulted in lower levels of triglycerides, lower levels of ApoB and a lower ApoB/ApoA-1 ratio, which concurred with other findings for sibutramine treatment, where favorable effects on HDL-cholesterol and triglycerides and total:HDL cholesterol ratio are reported [181]. In addition, SHBG levels increased in the sibutramine group: increased SHBG levels result in decreased availability of biologically active free testosterone [184] and may be a marker of metabolic benefit, as low SHBG is associated with insulin resistance and high plasma insulin levels [185]. However, sibutramine did not have any beneficial effects on blood pressure, fat distribution or insulin sensitivity index in young women with PCOS.…”

Section: Weight Reduction Treatment In Women With Pcossupporting

confidence: 87%

Metabolic Aspects of Polycystic Ovary Syndrome

2015

Postgraduate Obstetrics & Gynecology

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Section: Weight Reduction Treatment In Women With Pcossupporting

confidence: 87%

Metabolic Aspects of Polycystic Ovary Syndrome

2015

Postgraduate Obstetrics & Gynecology

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“…Haffner et al (38) have hypothesized that SHBG may reflect intracellular bioavailable testosterone better than total testosterone, with reduced SHBG expressing greater androgenicity. Insulin is also considered an important inhibitor of SHBG production (37). SHBG has been shown consistently to relate positively to HDL-cholesterol (15,35,39) and negatively to triglycerides, total and LDL-cholesterol (15), as well as to ApoB (18).…”

Section: Discussionmentioning

confidence: 99%

Endogenous sex hormones and risk factors for atherosclerosis in healthy Greek postmenopausal women

Lambrinoudaki¹,

Christodoulakos²,

Rizos

et al. 2006

eur j endocrinol

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Objective: To assess the association between endogenous sex hormones and risk factors for atherosclerosis in healthy postmenopausal women. Design: Cross-sectional study in a university menopause clinic. Methods: Serum sex hormones and lipid-lipoprotein profile, arterial pressure, homocysteine and insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA-IR), were assessed in 598 healthy postmenopausal women not on hormone therapy. Results: Compared with women in the lowest testosterone quartile (Q), women in the highest testosterone quartile had higher total cholesterol (Q1: 225.2G41.3 vs Q4: 246.2G38.4 mg/dl, P!0.01), low-density lipoprotein (LDL)-cholesterol (Q1: 146.9G37.2 vs Q4: 171.8G35.3 mg/dl, P!0.001), atherogenic index of plasma (AIP) (Q1: -0.224G0.238 vs Q4: -0.087G0.254, P!0.01), apolipoprotein B (ApoB) (Q1: 100.7G23.1 vs Q4: 113.9G23.8 mg/dl, P!0.001) and higher highdensity lipoprotein (HDL)-cholesterol (Q1: 60.7G14.5 vs Q4: 52.9G13.0 mg/dl, P!0.01). Accordingly, women in the highest free androgen index (FAI) quartile had higher AIP (Q1: -0.232G0.254 vs Q4: -0.078G0.243, P!0.001) and ApoB (Q1: 102.4G25.5 vs Q4: 114.2G 25.8 mg/dl, P!0.01) and lower HDL-cholesterol (Q1: 62.0G15.7 vs Q4: 51.9G11.6 mg/dl, P!0.001) and apolipoprotein A (Q1: 159.6G25.6 vs Q4: 147.9G24.1 mg/dl, P!0.01) compared with women in the lowest FAI quartile. These differences remained significant after adjustment for age, body mass index (BMI), insulin resistance and social habits. The free estrogen index (FEI) exhibited similar associations to the FAI. HOMA-IR showed an independent positive association with total testosterone (Q1: 2.00G1.36 vs Q4: 2.66G1.60, P!0.01), FAI (Q1: 1.70G1.12 vs Q4: 3.04G1.66, P!0.001) and FEI (Q1: 1.70G0.91 vs Q4: 3.08G1.77, P!0.001). Conclusions: Increased androgenicity in healthy postmenopausal women is associated with an unfavorable cardiovascular risk profile. High endogenous estradiol is related to a pro-atherogenic lipid profile, an association which may, in part, be mediated by insulin resistance. 154 907-916 European Journal of Endocrinology

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“…The best known function of SHBG is to regulate the availability of biologically active free testosterone and estradiol and their metabolic clearance rate [15]. Moreover, plasma concentration of SHBG is itself modulated by sex hormones [16], since it is stimulated by estrogens, and inhibited by androgens which thus increase their own bioavailability.…”

Section: Discussionmentioning

confidence: 99%

Sex hormone-binding globulin is a major determinant of the lipid profile: the PRIME study

et al. 2005

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The prevalence of coronary heart disease is much higher in men than in women and sex hormones might play a role in these differences through their influence on the lipid profile. The aim of this cross-sectional study was to study the relationship between hormonal markers (total testosterone (TT), estradiol (E2), sex-hormone-binding globulin (SHBG)) and plasma lipids in a population-based sample. Subjects were 352 men, 50-59 years old, selected in France (Lille, Strasbourg and Toulouse) and Northern-Ireland (Belfast) who had questionnaires and a medical examination at baseline of the PRIME prospective study (1991)(1992)(1993). Pearson correlation coefficients and Student's t tests were used to identify factors associated with plasma lipids. Multiple linear regression models were used for multivariate analyses, using triglycerides (TG) (log-transformed) and high density-lipoprotein cholesterol (HDL-C) as dependent variables. SHBG and TT were negatively correlated with TG (p < 0.0001 and p < 0.05, respectively) and positively correlated with HDL-C (p < 0.0001 and p < 0.01). E2 was positively correlated with TG (p < 0.05). No significant association was found between sex-hormones and LDL-C. In multiple linear regression analyses, SHBG remained independently associated negatively with TG (p < 0.01) and positively with HDL-C (p < 0.0001) after adjustment for centre of recruitment, age, body mass index, systolic blood pressure, smoking, alcohol intake and physical activity. After further adjustment for insulin, the association between SHBG and HDL-C remained highly significant (p < 0.0001). The association between SHBG and TG was weakened but remained also significant. Our results suggest that SHBG might to be a central protein in the hormonal regulation of the lipid profile.

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Plasma Steroid-Binding Proteins

Cited by 166 publications

References 130 publications

Metabolic Aspects of Polycystic Ovary Syndrome

Metabolic Aspects of Polycystic Ovary Syndrome

Endogenous sex hormones and risk factors for atherosclerosis in healthy Greek postmenopausal women

Sex hormone-binding globulin is a major determinant of the lipid profile: the PRIME study

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