Plasma testosterone and dehydroepiandrosterone sulfate in male and female patients with dysthymic disorder

Markianos, Manolis; Tripodianakis, J; Sarantidis, D; Hatzimanolis, John

doi:10.1016/j.jad.2006.11.013

Cited by 52 publications

(35 citation statements)

References 13 publications

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“…These behavioural differences correlated with changes in HPA-axis regulation: aged rats with diminished E2 exhibited increased corticosterone response to ether stress and ACTH challenge whilst chronic treatment with E2 corrected the phenotype (Ferrini et al, 1999;Lo et al, 2006). Interestingly, the HPG-axis is also curtailed in HD patients (Markianos et al, 2005(Markianos et al, , 2007Van Raamsdonk et al, 2007b) as well as in rodent models of HD (Hannan and Ransome, 2012;Papalexi et al, 2005;Van Raamsdonk et al, 2007b). Whilst there has only been a few studies examining the role sex hormones in HD, this evidence suggests that changes to E2 levels, subsequently leading to heightened HPA-axis activity, could contribute to depression in HD.…”

Section: Introductionmentioning

confidence: 96%

The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease

Pang

et al. 2015

Experimental Neurology

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Section: Introductionmentioning

confidence: 96%

The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease

Pang

et al. 2015

Experimental Neurology

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“…Hence, DHEA(S) is assumed to be involved in stress responses [20] as well as in a broad range of behavioral functions [21]. Due to these characteristics, DHEA(S) has been implicated in the pathophysiology of various psychiatric disorders including major depression [22], bipolar disorder [23], dysthymic disorder [24], panic disorder [25], borderline personality disorder [26], eating disorder [27], posttraumatic stress disorder (PTSD) [28], and schizophrenia [29,30]. Several studies have investigated baseline DHEA(S) levels and cortisol/DHEA(S) ratios in schizophrenia patients, although their findings are not necessarily consistent.…”

Section: Introductionmentioning

confidence: 99%

Elevated Cortisol Level and Cortisol/DHEAS Ratio in Schizophrenia as Revealed by Low-Dose Dexamethasone Suppression Test

Hori¹

2012

TONEUROPPJ

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Abstract:Earlier studies have used the dexamethasone (DEX) suppression test (DST) to investigate the hypothalamicpituitary-adrenal (HPA) function in schizophrenia, although the findings are controversial. Recently there has been an increased interest in the role of dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) in HPA axis function. Several studies have investigated basal DHEA(S) levels and cortisol/DHEA(S) ratios in schizophrenia patients, while no attempts have been made to investigate DHEA(S) level in response to the DEX administration. We aimed to compare the post-DEX cortisol and DHEAS levels and the cortisol/DHEAS ratio between schizophrenia patients and healthy controls. Here we administered the DST to 43 patients with schizophrenia and 37 age-and sex-matched healthy controls. Plasma cortisol levels, serum DHEAS levels, and cortisol/DHEAS ratio after administration of 0.5 mg of DEX were compared between the two groups. Schizophrenia patients showed significantly higher cortisol level and cortisol/DHEAS ratio than controls, while DHEAS levels were not significantly different between groups. These results suggest that besides the cortisol level, cortisol/DHEAS ratio as assessed with the DST might reflect abnormal HPA axis function in schizophrenia.

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“…Reduced testosterone levels and increased levels of dehydroepiandrosterone sulfate (DHEA; the major androgen secreted by the adrenals) were found in female tgHD rats [79] . However, female HD patients do not show alterations in testosterone or DHEA [109] and studies in male HD patients revealed reduced DHEA levels [104] . Interestingly, male tgHD rats displayed biphasic alterations in 17 ␤ -estradiol with increased levels in 4-month-old rats and decreased levels in 14-month-old rats compared to wild-type littermates [79] .…”

Section: Alterations In the Hypothalamic-pituitary-gonad Axismentioning

confidence: 90%

Huntington’s Disease – New Perspectives Based on Neuroendocrine Changes in Rodent Models

Petersén¹,

Hult²,

Kirik³

2009

Neurodegener Dis

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Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although it is characterized by progressive motor impairments, cognitive changes and psychiatric disturbances are major components of the disease. In addition, recent studies have shown that other non-motor symptoms such as alterations in sleep pattern, disruption of the circadian rhythm and increased energy metabolism are common and occur early. Emerging evidence suggests that the latter symptoms are likely results of disturbed functions of the hypothalamus and neuroendocrine circuits, which are known to be central in the regulation of emotion, sleep and metabolism. Whereas clinical data are essential to define key pathological features of HD, animal models that can recapitulate the neurobiological and behavioral features of the disorder are critical tools to elucidate the underlying pathogenic mechanisms. Recent studies employing different HD rodent models have been instrumental in identifying a number of neuroendocrine alterations as well as in highlighting novel potential disease pathways. This review summarizes the current state of knowledge derived from neuroendocrine studies in rodent models of HD in light of clinical relevance and points to future implications for this emerging field.

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Plasma testosterone and dehydroepiandrosterone sulfate in male and female patients with dysthymic disorder

Cited by 52 publications

References 13 publications

The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease

The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease

Elevated Cortisol Level and Cortisol/DHEAS Ratio in Schizophrenia as Revealed by Low-Dose Dexamethasone Suppression Test

Huntington’s Disease – New Perspectives Based on Neuroendocrine Changes in Rodent Models

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