Plasma Thrombin-activatable Fibrinolysis Inhibitor Levels Correlate with the Disease Activity of Ulcerative Colitis

Abstract

Objective Patients with ulcerative colitis (UC) are at an increased risk for thromboembolic events, particularly in patients with extensive and active disease. To date, a few studies have been published on the role of thrombin-activatable fibrinolysis inhibitor (TAFI) in UC. However, there are no reports in the literature investigating the effect of UC treatment on plasma TAFI levels. Methods The plasma TAFI antigen levels were quantitatively determined using ELISA kits for 20 UC patients at activation and remission, along with 17 healthy controls. The association between the TAFI levels and inflammatory markers was assessed to determine UC activation. To predict and determine the activation of UC, the Truelove-Witts index and the endoscopic activation index (EAI) were used for each subject. Results The plasma TAFI levels were higher in UC patients at activation of the disease compared with the remission state and in healthy controls. Spearman's correlation analyses revealed that the WBC (r: 0.586, p< 0.001), hsCRP (r: 0.593, p<0.001) and EAI (r: 0.721, p<0.001) were significantly correlated with the TAFI levels. The overall accuracy of TAFI in determining UC activation was 82.5% with a sensitivity, specificity, NPV and PPV of 80%, 85%, 81% and 84.2%, respectively (cut-off value: 156.2% and AUC: 0.879). Conclusion The present study demonstrates that the TAFI levels are elevated in the active state of UC. The assessment of TAFI levels in patients with UC in conjunction with other markers of inflammation may provide additional information for estimating UC activation and severity.

Increased thrombin-activatable fibrinolysis inhibitor levels in patients with chronic rhinosinusitis with nasal polyps

“…27,28 It is also known that circulating TAFI levels are enhanced in patients with several diseases, including rheumatoid arthritis and inflammatory bowel disease 29,30 ; reflect the degree of inflammation; and can be decreased by treatment. 30,31 Thrombomodulin is a transmembrane glycoprotein expressed on the surfaces of all vascular endothelial cells and many other types of cells, which contributes to maintenance of homeostasis during the inflammatory response. 32 Thrombin and thrombin/ thrombomodulin complexes can activate TAFI.…”

Ülseratif kolitte hastalığın şiddetini öngörmede non-invaziv belirteçler olarak hematolojik parametrelerin değerlendirilmesi

“…Bu patolojik durumun saptanması ve hastalık şiddetinin ortaya konulması, gerek takip gerekse tedavi için önem arz etmektedir. ÜK' da hastalık aktivitesinin değerlendirilmesi ve tedavinin şekillendirilmesi için birçok klinik aktivite indeksi ve non invaziv belirteç araştırılmış fakat hiçbiri inflamatuvar aktivitenin saptanmasında histopatolojik ve endoskopik incelemeler kadar kesin bulgu vermemiştir (2). Bu indeksler içerisinde ÜK için yaygın kullanım bulan klinik indeksler; Truelove-Witts ve Rachmilewitz Klinik Kolit Aktivite İndeksi (CCAİ)' dir (3).…”

Thrombin-Activatable Fibrinolysis Inhibitor Gene Polymorphism (TAFI1040C/T) in Women With Recurrent Spontaneous Abortion

“…Although the pathophysiological role of TAFI in downregulation of fibrinolysis 9 and its role in inflammation 10 point to its possible role in RSA, the published data about TAFI 1040 C/T polymorphism in complicated pregnancies, including RSA, are limited and inconsistent. Moreover, it did not confer its possible association with RAS.…”