Plasma tissue inhibitor of metalloproteinase-1 levels are elevated in essential hypertension and related to left ventricular hypertrophy

Timms, Peter; Wright, Ann; Maxwell, Paul R.; Campbell, Stewart; Dawnay, A; Srikanthan, V.

doi:10.1016/s0895-7061(01)02316-0

Cited by 51 publications

(31 citation statements)

References 13 publications

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“…In this view, increased levels of TIMP-1 have been related to left ventricular hypertrophy. 20 Another finding of this study was the association of endothelial dysfunction with oxidative stress. We found decreased serum levels of antioxidants, especially vitamin C and selenium, and also decreased activity of erythrocyte glutathione peroxidase and superoxide dismutase.…”

Section: Discussionmentioning

confidence: 65%

“…9 In this view, several acute-phase reactants, soluble adhesion molecules, chemokines and metalloproteinases are altered in patients at risk of cardiovascular events, such as hypertensives, [13][14][15][16][17] diabetics 18 or those with left ventricular hypertrophy. 19,20 Moreover, in patients with coronary heart disease some of these serum markers have prognostic implications. [21][22][23] The aim of this study was to evaluate the correlation between the degree of endothelial dys-function, as measured by the maximal acetylcholine-induced forearm vasodilation, and the serum level of biochemical markers of inflammation, remodeling and oxidative stress, in a group of newly diagnosed, never-treated, essential hypertensive patients.…”

Section: Introductionmentioning

confidence: 99%

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Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension

Sierra

Larrousse

2009

J Hum Hypertens

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To assess the correlation between endothelial dysfunction and the serum levels of biomarkers of inflammation, remodelling and oxidative stress in essential hypertension, 78 treatment-naïve essential hypertensives (mean age 43 years) underwent measurement of endothelial dysfunction, using the maximal acetylcholine-induced forearm vasodilation and serum levels of adhesion molecules, selectins, chemokines, metalloproteinases, copper, zinc, selenium, vitamins, homocysteine, malondialdehyde, erythrocyte glutathione peroxidase and erythrocyte superoxide dismutase. Mean ( ± s.e.m.) maximal acetylcholine-induced vasodilation was 367± 20%. Patients with a more impaired acetylcholine-dependent vasodilation (first tertile) had increased levels of e-selectin (P ¼ 0.009), p-selectin (Po0.001), monocyte chemotactic protein type 1 (MCP-1; P ¼ 0.012) and the tissue inhibitor of metalloproteinases type 1 (TIMP-1; P ¼ 0.044), which in turn showed significant inverse correlations with maximal endothelium-dependent vasodilation. Serum levels of selenium (P ¼ 0.012), vitamin C (P ¼ 0.038), erythrocyte glutathione peroxidase (Po0.001) and superoxide dismutase (P ¼ 0.022) activities were reduced in patients with a more impaired endothelium-dependent vasodilation. Recently diagnosed treatment-naïve essential hypertensives showed a relationship between the endothelial dysfunction, serum markers of inflammation and remodelling and levels of antioxidant substances. These could be potentially helpful markers of high risk in hypertensive patients.

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension

Sierra

Larrousse

2009

J Hum Hypertens

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“…Among the stromelysins group, both MMP-3 and MMP-10 have similar substrate specificity, but MMP-3 has a higher proteolytic efficiency than that of MMP-10 (Visse and Nagase 2003). In hypertensive subjects, plasma MMPs and their TIMPs were increased and associated with LVH and LVDD (Lindsay et al 2002;Timms et al 2002;Tayabjee et al 2004). Therefore, we selected two different members of MMPs family to investigate their role in hypertensive LVH and LVDD.…”

Section: Measurement Of Plasma Mmps Concentrationsmentioning

confidence: 99%

“…Changes in the structure of the cardiac extracellular matrix (ECM) can impede left ventricular filling during diastole, and possibly contribute to symptomatic diastolic dysfunction. Indeed, it has been reported that circulating matrix metalloprotienase-9 level and tissue inhibitor matrix metalloprotienase-1 levels are higher in hypertensive subject than controls, and tissue inhibitor matrix metalloprotienase-1 levels are associated with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD) in some but not all studies (Laviades et al 1998;Li-Saw-Hee et al 2000;Lindsay et al 2002;Timms et al 2002;Tayabjee et al 2004).…”

mentioning

confidence: 99%

Contribution of Plasma Matrix Metalloproteinases to Development of Left Ventricular Hypertrophy and Diastolic Dysfunction in Hypertensive Subjects

Sağlam

Karakaya

Esen

et al. 2006

Tohoku J. Exp. Med.

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Matrix metalloproteinases (MMPs) are involved in the regulation of the extracellular matrix (ECM) of the myocardium and thus the pathogenesis of vascular and cardiac hypertrophy. In this study, we investigated contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy (LVH) and diastolic dysfunction in hypertensive subjects. Hypertensive patients with (n = 27) and without LVH (n = 23) were included. All participants underwent a complete transthoracic echocardiographic examination, including recordings of the mitral annular early, late, systolic and diastolic velocities by Doppler imaging. Plasma concentrations of MMP-3 and MMP-9 were determined by the one-step sandwich enzyme immunoassay method. Plasma MMP-3 and MMP-9 concentrations were significantly higher in patients with LVH than those without LVH (2.4 ± 1.2 vs 1.5 ± 0.7 ng/ml, p = 0.006 and 5.2 ± 2.8 vs 3.3 ± 1.7 ng/ml, p = 0.003, respectively). MMP-3 and MMP-9 levels were also correlated with left ventricular posterior wall thickness and Doppler indices of diastolic dysfunction. Our findings have suggested that increased MMP levels may contribute to LVH and left ventricular diastolic dysfunction. Therefore, treatment of hypertension with MMP lowering drugs, such as angiotensin converting enzyme inhibitors and angiotensin receptor blockers, may have favorable effects on LVH and left ventricular diastolic dysfunction. matrix metalloproteinases; left ventricular hypertrophy; diastolic dysfunction

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“…ACEi/ARB and spironolactone therapy have been shown to partly reverse the abnormal metabolism of cardiac collagen tissue and enhance cardiac function in ICM patients. 16,19,[22][23][24] Improvements in haemodynamics and electromechanical synchronization after CRT appear to be related to corrected collagen metabolism. 25,26 However, no clinical observations of the effect of CRT on collagen metabolism in ICM have previously been reported.…”

Section: Discussionmentioning

confidence: 99%

Improvement in collagen metabolism after 12 weeks’ cardiac resynchronization therapy in patients with ischaemic cardiomyopathy

Zhou

et al. 2013

J Int Med Res

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Objectives: To investigate the effects of cardiac resynchronization therapy (CRT) on collagen metabolism biomarkers and their relationship to cardiac function, in patients with ischaemic cardiomyopathy (ICM). Methods: Serum levels of matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP-9 (TIMP-1), carboxyterminal propeptide of type I procollagen (PICP) and carboxyterminal telopeptide of type I collagen (ICTP) were quantified before and after 12 weeks' treatment, in patients with ICM receiving CRT and standard medical therapy (CRT group) or standard medical therapy alone (non-CRT group), and in controls. Cardiac function was measured echocardiographically. Results: MMP-9, TIMP-1, ICTP and the MMP-9/TIMP-1 ratio were significantly higher, and the PICP/ICTP ratio significantly lower, in patients with ICM (n ¼ 27) compared with controls (n ¼ 20). After 12 weeks' treatment, MMP-9, TIMP-1, ICTP and the MMP-9/TIMP-1 ratio were significantly higher, and the PICP/ICTP ratio significantly lower, in the non-CRT group (n ¼ 15) compared with the CRT group (n ¼ 12). The PICP/ICTP ratio correlated positively with TIMP-1 and negatively with MMP-9. The early/atrial ratio and left ventricular ejection fraction correlated positively and negatively, respectively, with the MMP-9/TIMP-1 ratio. Echocardiographic measurements of cardiac function were significantly worse in patients with ICM compared with controls and improved significantly after treatment in the CRT group. Conclusions: In ICM, collagen degradation biomarkers were elevated and correlated positively with cardiac function. CRT partially reversed the deterioration in collagen metabolism and enhanced cardiac function.

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Plasma tissue inhibitor of metalloproteinase-1 levels are elevated in essential hypertension and related to left ventricular hypertrophy

Abstract: The increased tissue collagen III levels found in the heart and vessels of hypertensive patients is due to a reduction in collagen degradation because of high TIMP-1 levels, rather than an increase in synthesis of collagen type III. The tissue source of this TIMP-1 is unclear.

Cited by 51 publications

References 13 publications

Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension

Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension

Contribution of Plasma Matrix Metalloproteinases to Development of Left Ventricular Hypertrophy and Diastolic Dysfunction in Hypertensive Subjects

Improvement in collagen metabolism after 12 weeks’ cardiac resynchronization therapy in patients with ischaemic cardiomyopathy

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