Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis

Peluso, Ilaria; Cavaliere, Arturo; Palmery, Maura

doi:10.1186/s12929-016-0268-x

Cited by 43 publications

(41 citation statements)

References 90 publications

(212 reference statements)

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“…W wielu badaniach potwierdzono, że pacjenci z łuszczycą mają zwiększo-ne stężenia markerów peroksydacji (m.in. ox-LDL, autoprzeciwciała przeciwko ox-LDL, dialdehyd malonowy, homocysteina), a zaburzenia te zwykle korelowały z aktywnością łuszczycy i czasem jej trwania [9,[47][48][49].…”

Section: Stres Oksydacyjnyunclassified

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The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

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Psoriasis, affecting 2-4% of the world's population, is a chronic recurrent inflammatory skin disease. Its multifactorial aetiopathogenesis consists of, for example, abnormal epidermal proliferation, immune disturbances, and genetic, psychosomatic, environmental and hormonal factors. Psoriasis is also considered to be a systemic disorder closely associated with cardiovascular diseases, atherosclerosis, diabetes mellitus, obesity or metabolic syndrome. Lipids have a variety of biological functions. They participate not only in energy storage and expenditure or the formation of cell membranes, but also in inflammatory and metabolic signalling pathways. Disturbances in their homeostasis lead to the development of immunometabolic disorders, including psoriasis. Based on the available literature, this article presents selected molecular and clinical aspects involved in the multidirectional effect of lipids on psoriasis.streszczenie Łuszczyca, która występuje u 2-4% populacji na świecie, jest przewlekłą i nawrotową chorobą zapalną skóry. Na jej wieloczynnikową etiopatogenezę składają się m.in. nieprawidłowa proliferacja naskórka, zaburzenia immunologiczne, czynniki genetyczne, psychosomatyczne, środowiskowe i hormonalne. Łuszczyca jest również uznawana za schorzenie ogólnoustrojowe, związane z chorobami układu sercowo--naczyniowego, miażdżycą, cukrzycą, otyłością i zespołem metabolicznym. Lipidy pełnią wiele biologicznych funkcji, biorą udział nie tylko w magazynowaniu i wydatkowaniu energii, tworzeniu błon komórko-wych, lecz także w zapalnych i metabolicznych szlakach sygnałowych. Zaburzenia ich homeostazy powodują rozwój schorzeń immunometabolicznych, w tym łuszczycy. W niniejszej pracy przedstawiono na podstawie dostępnego piśmiennictwa wybrane aspekty molekularne i kliniczne wielokierunkowego wpływu lipidów na łuszczycę.

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Section: Stres Oksydacyjnyunclassified

“…Dermatology Review/Przegląd Dermatologiczny 2017/6 typically been correlated with the activity and duration of psoriasis [9,[47][48][49].…”

Section: Stres Oksydacyjnymentioning

confidence: 99%

The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

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“…Oksidatif stres psöriasis için patofizyolojik bir neden olmasına karşılık, bu alanda birçok biyobelirteç kullanılmış ve çelişkili sonuçlar bulunmuştur (4,(6)(7)(8)(9)(10)(11) . Bazı çalışmalarda artan belirteçler, bazı çalışmalarda ya azalmış ya da değişmemiştir.…”

Section: Psöriasis Etiyolojisi Tam Bilinmeyen Multifaktoriyel Kronik unclassified

Clinical Value of Antioxidant Enzymes and Oxidative Biomarkers in Psoriasis

Ataş¹,

Hacınecipoğlu²,

Gönül³

et al. 2017

Okmeydani Medical Journal

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“…During last years there was formed the vector of serious and torpid psoriasis forms growth that is undoubtedly interesting for researchers and specialists. This dermatosis is considered as genetically determined disease which proceeds as inflammatory process in derma with disorder of proliferation and differentiation of keratinocytes under effect of different trigger factors [3,4]. In spite of many researches none of the existing hypotheses is recognized up to now.…”

Section: -№5 (98) -с 31-38mentioning

confidence: 99%

Clinical efficiency and dermoprotection of 2-ethyl-6-methyl-3-hydroxypyridine succinate drug in case of psoriasis: from the antioxidation point of view

Visir

Макурина

2016

ZMJ

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Objective. To study the clinical significance of oxidative processes modulation within frames of 2-ethyl-6-methyl-3-hydroxypyridine succinate dermatropic efficiency assessment in patients with psoriasis affected by arterial hypertension.Materials and methods. The results of this study are based on data of comprehensive examination and supervision of 30 patients suffering from psoriasis with different clinical forms such as normal levels of blood pressure (the control group) or in combination with hypertension (the study group).Results. The comparative description of the antioxidative therapy efficiency was performed by the end of treatment. The findings showed significantly positive antioxidant-dependent mechanisms of 2-ethyl-6-methyl-3-hydroxypyridine succinate clinical efficiency in patients with psoriasis affected by arterial hypertension.In case of patients with combined psoriasis and essential hypertension course 2-ethyl-6-methyl-3-hydroxypyridine succinate therapy caused reliable decrease of free-radical oxidation intensification in particular nitrosative (reliable decrease of nitrotyrosine) and oxidative (negative dynamics of endothelin-1 and positive dynamics as to glutathione metabolism) stresses. That, in its turn, decreased the evidence of apoptotic and inflammatory processes (caspase-8 and TNF-α regress) both directly and indirectly by means of mediating anti-inflammatory effect on endothelium cells and macrophages of anticoagulant proteinase through endothelial protein C receptor (EPCR) with production of components and structures of extracellular matrix and disturbance of microcirculation. Thus, it determines the key pathogenetic aspects of psoriasis. The decrease of VEGF expression indicators level (vascular endothelial growth factor) and serotonin, associated with this combined therapy, had stipulated statistically significant positive clinical and subjective effect in form of regress of dermatological changes (PASI index), decrease of itch (optimization of serotonin biosynthesis and reduction of methionine conversion (with homocysteine formation)) and improvement of life quality.Conclusions. Taking into account potential influence of 2-ethyl-6-methyl-3-hydroxypyridine succinate on these pathophysiological predictors and pathogenesis, which are to some extent involved in formation and progression of psoriatic disease, use of 2-ethyl-6-methyl-3-hydroxypyridine succinate is sufficiently effective in conditions of psoriasis therapy optimization. Zaporozhye medical journal 2016; №5 (98): 31-38Клінічна ефективність і дермопротекція 2-етил-6-метил-3-гідроксипіридину сукцинату при псоріазі: погляд із позицій антиоксидації В. А. Візір, Г. І. МакурінаРекомендації щодо терапії пацієнтів, які страждають одночасно на псоріаз та артеріальну гіпертензію, вкрай нечисленні. Мета роботи -вивчити клінічну значущість модуляції оксидативних процесів у рамках оцінювання дерматотропної ефективності 2-етил-6-метил-3-гідроксипіридину сукцинату у хворих на псоріаз на тлі артеріальної гіпертензії.Матеріали та методи. Резу...

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Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis

Cited by 43 publications

References 90 publications

The role of lipids in psoriasis

The role of lipids in psoriasis

Clinical Value of Antioxidant Enzymes and Oxidative Biomarkers in Psoriasis

Clinical efficiency and dermoprotection of 2-ethyl-6-methyl-3-hydroxypyridine succinate drug in case of psoriasis: from the antioxidation point of view

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