Plasma Total Ascorbic Acid and Serum 25-Hydroxy-Vitamin-D Status in Patients with Venous Leg Ulcers: A Case–Control Study

Abstract

Venous leg ulcers (VLUs) pose a significant burden on patients, health care systems, and national economies. Nutritional health is an important determinant of wound healing. Vitamin C and D levels and additional biochemical markers, C-reactive protein, and albumin in a group of patients with VLUs, were compared with a control group without VLUs. No significant difference in either nutrient marker was found with the presence, size, or duration of VLUs. Obesity was significantly more common in the VLU group, as noted in other studies. Additional controlled studies should be performed with measures of VLU size and duration to assess long-term outcomes with nutritional therapy.

Bacterial Species Involved in Venous Leg Ulcer Infections and Their Sensitivity to Antibiotherapy—An Alarm Signal Regarding the Seriousness of Chronic Venous Insufficiency C6 Stage and Its Need for Prompt Treatment

“…Importantly, with the prevalence increasing in the elderly and significant negative effects on quality of life due to disability, social isolation, and psychosocial burden, venous leg ulceration will continue to present an important challenge, particularly in light of the expected increase in ageing and increasingly obese population. Venous leg ulcers represent a significant burden on patients, and for healthcare systems and national economies too, constituting a costly medical problem with a high toll on worldwide healthcare systems [ 4 , 5 ]. VLU treatment accounts for an annual expenditure of 1–2% of the national health budget, equating to over USD 2.5 billion in the United States and GBP 300–600 million in the United Kingdom [ 1 ].…”