Plasma total homocysteine in uncomplicated pregnancy and in preeclampsia

López‐Quesada, Eva; Vilaseca, M. A.; Laïlla, Josep M.

doi:10.1016/s0301-2115(02)00367-6

Cited by 64 publications

(44 citation statements)

References 19 publications

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“…On the other hand, some clinical studies have documented a familial tendency toward development of preeclampsia, suggesting a genetic factors could predispose women to develop it [47]. Hyperhomocysteinemia has also been described as a risk factor for PE and a promoter of endothelial dysfunction in preeclampsia [10,48].…”

Section: Discussionmentioning

confidence: 99%

Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis

Yang

Tang

et al. 2015

J Assist Reprod Genet

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Objectives MTHFR C677T and A1298C have been associated with the risk of preeclampsia (PE), but with conflicting results. We performed this meta-analysis to derive a more precise estimation of the association between MTHFR polymorphisms and PE. Study design An electronic search of PubMed and Chinese Biomedicine database was conducted to select studies for meta-analysis. 54 case controlled studies containing MTHFR C677T and A1298C gene polymorphisms were chosen, and odds ratio (OR) with confidence interval (CI) was used to assess the strength of this association. Result These studies evaluated 7398 cases and 11230 controls for MTHFR C677T. The overall results suggested that MTHFR C677T was associated with the risk of PE. (T vs. C: OR = 1.157, 95 % CI: 1.057-1.266, p=0.002; TT+CT vs. CC: OR=1.165, 95 % CI 1.049-1.293, P = 0.004; TT vs. CT + CC: OR = 1.371, 95 % CI: 1.153-1.63, p < 0.001). We also evaluated 1103 cases and 988 controls for MTHFR A1298C but could not demonstrate an increased risk of PE for this polymorphism (p=0.667). A symmetric funnel plot, the Egger's test (p = 0.819) suggested a lack of publication bias. ConclusionThis meta-analysis supports the idea that MTHFR C677T genotype is associated with increased risk for PE, especially in the case of Asians and Caucasians.

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Section: Discussionmentioning

confidence: 99%

Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis

Yang

Tang

et al. 2015

J Assist Reprod Genet

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“…59 Hyperhomocysteinemia has been associated with the development of PE, and the most common polymorphism associated with this condition is the thermolabile 677T allele of the MTHFR gene, which results in reduced enzyme activity and impaired homocysteine/folate metabolism, leading to moderate hyperhomocysteinemia. 5,60,61 The literature on the relationship between the MTHFR C677T polymorphism and PE risk is replete with small studies reporting controversial findings, and no clear consensus has been reached. We therefore performed a meta-analysis to form a more precise estimation of the association of the MTHFR C677T polymorphism and PE risk.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia

2012

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A number of studies have investigated the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of pre-eclampsia (PE) in various populations and have delivered inconsistent results. Therefore, this meta-analysis of 36 case-control studies, comprising 4253 PE cases and 4950 controls, were assessed to evaluate a possible association. The pooled results showed that the MTHFR C677T polymorphism was significantly associated with PE (P ¼ 0.03, odds ratio (OR) ¼ 1.25, 95% confidence interval (CI) ¼ 1.02-1.54, for the additive comparison; P ¼ 0.04, OR ¼ 1.14, 95% CI ¼ 1.01-1.29, for the dominant genetic model). The results of the subgroup analysis showed that MTHFR 677T had the effect of increasing the PE risk for the recessive genetic model (Po0.0001, OR ¼ 1.76, 95% CI ¼ 1.33-2.33, P heterogeneity ¼ 0.28), the additive comparison (P ¼ 0.002, OR ¼ 2.09, 95% CI ¼ 1.31-3.31, P heterogeneity ¼ 0.08) and allele contrasts (P ¼ 0.03, OR ¼ 1.42, 95% CI ¼ 1.04-1.95, P heterogeneity ¼ 0.0001) in the Asians, while no evidence of an association between MTHFR C677T polymorphisms and PE was observed in the Caucasians. This meta-analysis suggests that the MTHFR C677T polymorphism is capable of causing PE susceptibility in the Asians but not in the Caucasians.

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“…Plasma homocysteine concentration is reduced in normal pregnancy, probably due to increased plasma volume and associated hemodilution, increased glomerular filtration rate, hormonal changed associated with pregnancy and increased uptake of homocysteine by the fetus (Malinow et al 1998;Powers et al 1998;Hague 2003). Many studies have demonstrated the relationship between hyperhomocysteinemia and preeclampsia (Refsum et al 1998;Walker et al 1999;Hogg et al 2000;Vollset et al 2000;Lopez-Quesada et al 2003), while others have refuted an association (Hietala et al 2001;Raijmakers et al 2001;Middeldorp et al 2004). This relationship has been shown in early pregnancy (Cotter et al 2001), in the second trimester (Sorensen et al 1999;Hogg et al 2000), and in the third trimester of pregnancy (Sanchez et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Elevated Plasma Homocysteine Concentrations in Severe Preeclampsia and Eclampsia

İngeç

Borekci

Kadanali

2005

Tohoku J. Exp. Med.

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INGEC, M., BOREKCI, B. and KADANALI, S. Elevated Plasma Homocysteine Concentrations in Severe Preeclampsia and Eclampsia. Tohoku J. Exp. Med., 2005, 206 (3), 225-231 Homocysteine is an essential amino acid required for the growth of cells and tissues in the human body. Maternal hyperhomocysteinemia is associated with a number of placenta-mediated diseases such as preeclampsia. The aim of this study was to evaluate the plasma level of homocysteine and its association with severity of preeclampsia. A case-control study was performed with 32 mild preeclamptic patients, 25 severe preeclamptic patients, 16 eclamptic patients and 34 controls. Maternal plasma homocysteine concentration was measured prospectively at antenatal period by high-performance liquid chromatography. There were no significant differences in demographic characteristics between the study and control groups. Mean plasma levels of homocysteine in women with severe preeclampsia (16.7 ± 10.1 μ mol/l, mean ± S.D., n = 25) and eclampsia (16.5 ± 9.6 μ mol/l, mean ± S.D., n = 16) were significantly higher than those in mild preeclampsia (7.7 ± 2.4 μ mol/l, mean ± S.D., n = 32) and controls (6.7 ± 1.6 μ mol/l, mean ± S.D., n = 34) (p < 0.0001). It should be noted that plasma levels of homocysteine are not significantly different between mild preeclampsia and controls. In conclusion, plasma homocysteine concentrations are increased in severe preeclampsia and eclampsia, but not in mild preeclampsia.

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Plasma total homocysteine in uncomplicated pregnancy and in preeclampsia

Cited by 64 publications

References 19 publications

Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis

Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis

Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia

Elevated Plasma Homocysteine Concentrations in Severe Preeclampsia and Eclampsia

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