Plasma total homocysteine is a determinant of carotid intima-media thickness and circulating endothelial progenitor cells in patients with newly diagnosed hypertension

Bogdański, Paweł; Miller-Kasprzak, Ewa; Pupek-Musialik, Danuta; Jabłecka, Anna; Lacinski, M.; Jagodzińśki, Paweł P.; Jakubowski, Hieronim

doi:10.1515/cclm-2011-0856

Cited by 23 publications

(8 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Homocysteine (Hcy), another emergent CV risk factor [ 94 ], was shown to decrease EPC count and to impair EPCs activity [ 95 ]. Interestingly, in patients with newly diagnosed hypertension, Bogdanski et al found that Hcy levels are significantly associated with increased carotid IMT and decreased number of CFU-ECs and proposed as explanation that Hcy may interfere with the redox setting [ 96 ]. Vitamin D deficiency has been associated with CVD [ 97 , 98 ]; more recently, vitamin D has been suggested to exert effects on the CV system [ 99 ].…”

Section: Resultsmentioning

confidence: 99%

Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Aragona

Imbalzano

Mamone

et al. 2015

Stem Cells International

View full text Add to dashboard Cite

Objective. To identify, evaluate, and synthesize evidence on the predictive power of circulating endothelial progenitor cells (EPCs) in cardiovascular disease, through a systematic review of quantitative studies. Data Sources. MEDLINE was searched using keywords related to “endothelial progenitor cells” and “endothelium” and, for the different categories, respectively, “smoking”; “blood pressure”; “diabetes mellitus” or “insulin resistance”; “dyslipidemia”; “aging” or “elderly”; “angina pectoris” or “myocardial infarction”; “stroke” or “cerebrovascular disease”; “homocysteine”; “C-reactive protein”; “vitamin D”. Study Selection. Database hits were evaluated against explicit inclusion criteria. From 927 database hits, 43 quantitative studies were included. Data Syntheses. EPC count has been suggested for cardiovascular risk estimation in the clinical practice, since it is currently accepted that EPCs can work as proangiogenic support cells, maintaining their importance as regenerative/reparative potential, and also as prognostic markers. Conclusions. EPCs showed an important role in identifying cardiovascular risk conditions, and to suggest their evaluation as predictor of outcomes appears to be reasonable in different defined clinical settings. Due to their capability of proliferation, circulation, and the development of functional progeny, great interest has been directed to therapeutic use of progenitor cells in atherosclerotic diseases. This trial is registered with registration number: Prospero CRD42015023717.

show abstract

Section: Resultsmentioning

confidence: 99%

Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Aragona

Imbalzano

Mamone

et al. 2015

Stem Cells International

View full text Add to dashboard Cite

show abstract

“…During HHcy, increased reactive oxygen species, matrix metalloproteinase, and decreased endothelial nitric oxide cause vascular constriction and stiffness, which could lead to essential hypertension [27] . A clinical study came to the same conclusion, that Hcy was a determinant of vascular thickness and compliance in hypertensive patients [28] , [29] and that HHcy increased the risk of cerebrovascular complications and glomerular sclerosis [30] , [31] . There is a pathogenic effect of Hcy on the vasculature, but the data on the relationship between Hcy levels and vascular biology at the initial stages of hypertension was limited.…”

Section: Discussionmentioning

confidence: 96%

Homocysteine as a Risk Factor for Hypertension: A 2-Year Follow-Up Study

et al. 2014

View full text Add to dashboard Cite

Homocysteine (Hcy) is regarded as a risk factor for hypertension, but research on the causal relationship between Hcy and hypertension is limited. In the present study, we prospectively tracked the blood pressure progression of a normotensive population with different Hcy levels over a 2-year period. The incidence of hypertension with increasing Hcy quartiles produced an approximately U-shaped curve, with significance in males. Compared with the third quartile, the risk of hypertension in the first and second quartiles was increased by 1.55 (95% confidence interval [CI] 1.154–2.081) fold and 1.501 (95% CI 1.119–2.013) fold, respectively, with the increase being more significant in males. In conclusion, Hcy is related to hypertension incidence with the results approximating an U-shaped curve. Low Hcy levels might also increase the risk of hypertension.

show abstract

“…The Framingham study (9) reported that the number of EC colony‐forming units (referred to as EPCs) in peripheral blood (PB) was associated with cardiovascular risk scores, a clinical index for 10‐year risk of developing coronary heart disease (CHD) based on age, total cholesterol level, HDL cholesterol level, smoke, and systolic blood pressure. Decreased EPC population is associated with carotid intima‐media thickness and flow‐mediated vascular dilation in patients with hypertension (13, 14) and is also associated with endothelial dysfunction in patients on dialysis with chronic kidney disease (11, 15). It was reported that elevated plasma levels of homocysteine (Hcy) are associated with reduced circulating EPC counts in patients with CHD (16).…”

mentioning

confidence: 99%

Hyperhomocysteinemia suppresses bone marrow CD34 ⁺ /VEGF receptor 2 ⁺ cells and inhibits progenitor cell mobilization and homing to injured vasculature—a role of β1‐integrin in progenitor cell migration and adhesion

Nelson

Jiang

et al. 2015

FASEB j.

View full text Add to dashboard Cite

Hyperhomocysteinemia (HHcy) impairs re-endothelialization and accelerates vascular remodeling. The role of CD34(+)/VEGF receptor (VEGFR) 2(+) progenitor cells (PCs) in vascular repair in HHcy is unknown. We studied the effect of HHcy on PCs and its role in vascular repair in severe HHcy (∼150 μM), which was induced in cystathionine-β synthase heterozygous mice fed a high-methionine diet for 8 weeks. Vascular injury was introduced by carotid air-dry endothelium denudation. CD34(+)/VEGFR2(+) cells were examined by flow cytometry. HHcy reduced bone marrow (BM) CD34(+)/VEGFR2(+) cells and suppressed replenishment of postinjury CD34(+)/VEGFR2(+) cells in peripheral blood (PB). Donor green fluorescent protein-positive PC homing to the injured vessel was reduced in HHcy after CD34(+) PCs from enhanced green fluorescent protein mice were adoptively transferred following carotid injury. CD34(+) PC transfusion partially reversed HHcy-suppressed re-endothelialization and HHcy-induced neointimal formation. Furthermore, homocysteine (Hcy) inhibited proliferation, adhesion, and migration and suppressed β1-integrin expression and activity in human CD34(+) endothelial colony-forming cells (ECFCs) isolated from PBs in a dose-dependent manner. A functional-activating β1-integrin antibody rescued Hcy-suppressed adhesion and migration in CD34(+) ECFCs. In conclusion, HHcy reduces BM CD34(+)/VEGFR2(+) generation and suppresses CD34(+)/VEGFR2(+) cell mobilization and homing to the injured vessel via β1-integrin inhibition, which partially contributes to impaired re-endothelialization and vascular remodeling.

show abstract

Plasma total homocysteine is a determinant of carotid intima-media thickness and circulating endothelial progenitor cells in patients with newly diagnosed hypertension

Abstract: Our results suggest that Hcy might increase carotid artery IMT by reducing EPCs numbers. Possible involvement of Hcy in the reduction of EPCs number in hypertensive patients might be in part mediated by Hcy influence on the TAS.

Cited by 23 publications

References 38 publications

Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Homocysteine as a Risk Factor for Hypertension: A 2-Year Follow-Up Study

Hyperhomocysteinemia suppresses bone marrow CD34 ⁺ /VEGF receptor 2 ⁺ cells and inhibits progenitor cell mobilization and homing to injured vasculature—a role of β1‐integrin in progenitor cell migration and adhesion

Contact Info

Product

Resources

About

Plasma total homocysteine is a determinant of carotid intima-media thickness and circulating endothelial progenitor cells in patients with newly diagnosed hypertension

Abstract: Our results suggest that Hcy might increase carotid artery IMT by reducing EPCs numbers. Possible involvement of Hcy in the reduction of EPCs number in hypertensive patients might be in part mediated by Hcy influence on the TAS.

Cited by 23 publications

References 38 publications

Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Homocysteine as a Risk Factor for Hypertension: A 2-Year Follow-Up Study

Hyperhomocysteinemia suppresses bone marrow CD34 + /VEGF receptor 2 + cells and inhibits progenitor cell mobilization and homing to injured vasculature—a role of β1‐integrin in progenitor cell migration and adhesion

Contact Info

Product

Resources

About

Hyperhomocysteinemia suppresses bone marrow CD34 ⁺ /VEGF receptor 2 ⁺ cells and inhibits progenitor cell mobilization and homing to injured vasculature—a role of β1‐integrin in progenitor cell migration and adhesion