Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

Dilek, Fatih; Özkaya, Enis; Koçyiğit, Abdürrahim; Yazıcı, Mebrure; Güler, Eray Metin; Dündaröz, Mehmet Ruşen

doi:10.1177/0394632015621563

Cited by 11 publications

(8 citation statements)

References 25 publications

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“…The antioxidant enzymes which were depleted by oxidative stress of Cd were restored by ML. the antioxidant effects of ML were reported by other authors [12,51,52]. ML has direct free radical scavenger ability in addition to the antiinflammatory properties which itself diminish the oxidative stress effect on tissues.…”

Section: Discussionsupporting

confidence: 57%

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Ek¹,

Mf²,

Mg³

et al. 2017

IJCPT

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Adult male Sprague rats weighting (220 ± 30gm) were purchased from Faculty of Agriculture, Minia University Egypt. Experimen- AbstractCadmium (Cd) is a common environmental hazardous heavy metal. The standard treatment of heavy metal intoxication; chelators may have a minor role in Cd toxicity. Montelukast (ML) is an anti-inflammatory drug that is used mainly for managing asthmatic patients. Recent workers have tested ML for its antioxidant properties in various conditions and obtained encouraging results as regarding this effect. We investigated the protective and antioxidant effect of ML on pituitary gland, a highly sensitive organ to Cd toxicity. Four groups of rats were used and received distilled water, 10mg/kg ML, 3mg/kg Cd, and 10mg ML plus 3mg/kg Cd respectively. Antioxidant, histological, immunohistochemical and hormonal effects of Cd and ML were evaluated. The detrimental effect of Cd on pituitary gland was abolished by ML. The diminished hormonal effect of Cd was restored to normal levels. The increased MDA level and depleted oxidative enzymes on pituitary gland of rat exposed to Cd were restored by ML. lastly, histological and apoptotic effects of Cd were also, corrected significantly by ML. It is concluded that ML can protect against Cd-induced pituitary gland toxicity.

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Section: Discussionsupporting

confidence: 57%

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Ek¹,

Mf²,

Mg³

et al. 2017

IJCPT

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“…Plasma total thiol levels are reduced in patients with COPD or asthma. Furthermore the treatment with antioxidants is able to restore plasma total thiol levels in these pulmonary diseases [29]. As well known, smoking can cause a clear oxidative stress.…”

Section: Thiol Resultsmentioning

confidence: 96%

Alterations in Thiol/disulphide Homeostasis of Acute Lung Toxicity of Bleomycin in Rats

Parlar¹,

Arslan²,

Doğan³

et al. 2019

Chem Pharm Res

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Bleomycin (BLM)-induced pulmonary fibrosis, a progressive and lethal form of interstitial lung disease, is mediated through the generation of reactive oxygen species. Since the dynamic thiol/disulphide homeostasis is a substantial marker for oxidative stress, for future glutathione based methodological researches on the progressive BLM toxicity in lungs, it is very valuable to show that the toxic mechanism.We investigated the dynamic thiol/disulphide homeostasis in a rat model with BLM-induced pulmonary fibrosis. BLM (5 mg/kg) or saline was injected into the lungs as 0,1 ml by insuline syringe that inserted into gently opened trachea of anesthetized rats.Native thiol (SH), total thiol (total SH), and disulphide (SS) levels were measured in rat serum at pre-treatment, 24th hour, 2nd, 4th, 7th, 14th, and 28th days of BLM treatment, with a novel automated method recently described.The levels of native SH and total SH in BLM group were decreased at 24th hour and this reduction were gradually continued up to 28th day when compared with pre-treatment BLM and/or the saline control group. On the other hand there were significantly a high ratio in BLM group with %SS/SH at 4th day and %SS/total SH at 4th and 28th days while there was no difference at 7th and 14th days.Results clearly indicate that the thiol/disulphide homeostasis can be acutely disturbed in the experimental model of BLM-induced fibrosis. So this data offer a new modeling option to discuss the therapy strategies and the effect mechanisms of BLM-induced lung toxicity.

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“…Even so, GSH is the most abundant antioxidant found both in the epithelial cells [10] and the fluid lining them [72]. Asthma is associated with a decrease in total thiols [55,73]. A mouse model of OVA-induced asthma showed a cellular loss of GSH [74].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation: Oxidative Stress Modulation in a Mouse Model of Ovalbumin-Induced Acute Asthmatic Airway Inflammation

Adam-Bonci

Bonci

Pârvu

et al. 2021

IJMS

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Asthma oxidative stress disturbances seem to enable supplementary proinflammatory pathways, thus contributing to disease development and severity. The current study analyzed the impact of two types of oral vitamin D (VD) supplementation regimens on the redox balance using a murine model of acute ovalbumin-induced (OVA-induced) asthmatic inflammation. The experimental prevention group received a long-term daily dose of 50 µg/kg (total dose of 1300 µg/kg), whereas the rescue group underwent a short-term daily dose of 100 µg/kg (total dose of 400 µg/kg). The following oxidative stress parameters were analyzed in serum, bronchoalveolar lavage fluid (BALF) and lung tissue homogenate (LTH): total oxidative status, total antioxidant response, oxidative stress index, malondialdehyde and total thiols. Results showed that VD significantly reduced oxidative forces and increased the antioxidant capacity in the serum and LTH of treated mice. There was no statistically significant difference between the two types of VD supplementation. VD also exhibited an anti-inflammatory effect in all treated mice, reducing nitric oxide formation in serum and the expression of nuclear factor kappa B p65 in the lung. In conclusion, VD supplementation seems to exhibit a protective role in oxidative stress processes related to OVA-induced acute airway inflammation.

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Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy

Cited by 11 publications

References 25 publications

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Protective Effect of Montelukast against Cadmium Induced Pituitary Gland Toxicity

Alterations in Thiol/disulphide Homeostasis of Acute Lung Toxicity of Bleomycin in Rats

Vitamin D Supplementation: Oxidative Stress Modulation in a Mouse Model of Ovalbumin-Induced Acute Asthmatic Airway Inflammation

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