Plasma Treated Multi-Walled Carbon Nanotubes (MWCNTs) for Epoxy Nanocomposites

Ritts, Andrew C.; Yu, Qingsong; Li, Hao; Lombardo, Stephen J.; Han, Xu; Xia, Zhenhai; Lian, Jie

doi:10.3390/polym3042142

Cited by 26 publications

(14 citation statements)

References 32 publications

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“…It was found that the surface morphology of the samples had changed with a thin layer of compound (~ 1 nm) wrapped on the outer surfaces of biopolymeric MWSB nanocomposites. This observation was consistent with the previous finding reported earlier by a team working on plasma-coated MWCNT 44 . According to the HR-TEM analysis, they observed a layer of thick amorphous plasma nano-coated on the MWCNT surfaces when compared to the uncoated MWCNT.…”

Section: Resultssupporting

confidence: 94%

Preparation, characterisation and biological evaluation of biopolymer-coated multi-walled carbon nanotubes for sustained-delivery of silibinin

Tan

Saifullah

Fakurazi

et al. 2020

Sci Rep

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This research work represents the first major step towards constructing an effective therapeutic silibinin (SB) in cancer treatment using oxidised multi-walled carbon nanotubes (MWCNT-COOH) functionalised with biocompatible polymers as the potential drug carrier. In an attempt to increase the solubility and dispersibility of SB-loaded nanotubes (MWSB), four water-soluble polymers were adopted in the preparation process, namely polysorbate 20 (T20), polysorbate 80 (T80), polyethylene glycol (PEG) and chitosan (CHI). From the geometry point of view, the hydrophobic regions of the nanotubes were loaded with water-insoluble SB while the hydrophilic polymers functionalised on the outer surfaces of the nanotubes serve as a protective shell to the external environment. The chemical interaction between MWSB nanocomposites and polymer molecules was confirmed by Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. Besides, high-resolution transmission electron microscopy (HR-TEM), field emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA) and UV–visible spectrophotometry were also employed to characterise the synthesised nanocomposites. The morphological study indicated that the polymers were deposited on the external surfaces of MWSB and the nanocomposites were seen to preserve their tubular structures even after the coating process was applied. The TGA results revealed that the incorporation of biopolymers practically improved the overall thermal stability of the coated MWSB nanocomposites. Evaluation of the in vitro effect on drug release rate by the nanocomposites was found to follow a biphasic release manner, showing a fast release at an initial stage and then a sustained-release over 2500 min. Besides, the drug release mechanisms of the nanocomposites demonstrated that the amount of SB released in the simulated environment was governed by pseudo-second order in which, the rate-limiting step mainly depends on diffusion of drug through chemisorption reaction. Finally, MTT assay showed that the coated MWSB nanocomposites on 3T3 cells were very much biocompatible at a concentration up to 100 g/mL, which is an evidence of MWSB reduced cytotoxicity.

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Section: Resultssupporting

confidence: 94%

Preparation, characterisation and biological evaluation of biopolymer-coated multi-walled carbon nanotubes for sustained-delivery of silibinin

Tan

Saifullah

Fakurazi

et al. 2020

Sci Rep

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“…COOH-functionalized Au-decorated MWCNTs were obtained from McGill University, Canada, and diluted with d 2 H 2 O to a working concentration of 18–20 mg/L prior to conjugation, to ensure mono-dispersity. COOH functionalization was achieved by plasma treatment, a general method for the addition of functional groups at defects in graphene structures [ 36 , 37 ]. Au decoration was carried out by pulsed laser ablation using a Nd:YAG laser focused on the MWCNT target at a fluence on the order of 1 J/cm 2 .…”

Section: Methodsmentioning

confidence: 99%

Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells

et al. 2016

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BackgroundThe incidence of papillary thyroid carcinoma (PTC) has risen steadily over the past few decades as well as the recurrence rates. It has been proposed that targeted ablative physical therapy could be a therapeutic modality in thyroid cancer. Targeted bio-affinity functionalized multi-walled carbon nanotubes (BioNanofluid) act locally, to efficiently convert external light energy to heat thereby specifically killing cancer cells. This may represent a promising new cancer therapeutic modality, advancing beyond conventional laser ablation and other nanoparticle approaches.MethodsThyroid Stimulating Hormone Receptor (TSHR) was selected as a target for PTC cells, due to its wide expression. Either TSHR antibodies or Thyrogen or purified TSH (Thyrotropin) were chemically conjugated to our functionalized Bionanofluid. A diode laser system (532 nm) was used to illuminate a PTC cell line for set exposure times. Cell death was assessed using Trypan Blue staining.ResultsTSHR-targeted BioNanofluids were capable of selectively ablating BCPAP, a TSHR-positive PTC cell line, while not TSHR-null NSC-34 cells. We determined that a 2:1 BCPAP cell:α-TSHR-BioNanofluid conjugate ratio and a 30 second laser exposure killed approximately 60% of the BCPAP cells, while 65% and >70% of cells were ablated using Thyrotropin- and Thyrogen-BioNanofluid conjugates, respectively. Furthermore, minimal non-targeted killing was observed using selective controls.ConclusionA BioNanofluid platform offering a potential therapeutic path for papillary thyroid cancer has been investigated, with our in vitro results suggesting the development of a potent and rapid method of selective cancer cell killing. Therefore, BioNanofluid treatment emphasizes the need for new technology to treat patients with local recurrence and metastatic disease who are currently undergoing either re-operative neck explorations, repeated administration of radioactive iodine and as a last resort external beam radiation or chemotherapy, with fewer side effects and improved quality of life.

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“…However, small signal-to-noise ratio with our current technique gave technical difficulties as similarly observed in Ref. [13]. The confirmation of the functional groups still needs to be worked in the future with other diagnostic techniques.…”

Section: Resultsmentioning

confidence: 72%

Dispersion of multi-walled carbon nanotube in tetrahydrofuran functionalized with Ar/O2, Ar/N2, and Ar/N2/H2 plasma

Ogawa

Kato

Mori

et al. 2014

Surface and Coatings Technology

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Plasma Treated Multi-Walled Carbon Nanotubes (MWCNTs) for Epoxy Nanocomposites

Cited by 26 publications

References 32 publications

Preparation, characterisation and biological evaluation of biopolymer-coated multi-walled carbon nanotubes for sustained-delivery of silibinin

Preparation, characterisation and biological evaluation of biopolymer-coated multi-walled carbon nanotubes for sustained-delivery of silibinin

Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells

Dispersion of multi-walled carbon nanotube in tetrahydrofuran functionalized with Ar/O2, Ar/N2, and Ar/N2/H2 plasma

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