Plasma treatment as an efficient tool for controlled drug release from polymeric materials: A review

Petlin, D.G.; Tverdokhlebov, S. I.; Anissimov, Yuri German

doi:10.1016/j.jconrel.2017.09.023

Cited by 77 publications

(49 citation statements)

References 155 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among a number of methods of surface modification, plasma treatment is a well-known and highly effective technique to achieve the required surface properties without application of additional chemical reagents, which is especially desirable for modification of materials being developed for biomedical application [5][6][7][8]. Another significant benefit of plasma treatment relies on the possibility to vary the material's surface characteristics, namely chemical structure, morphology, hydrophilicity and surface charge by changing a number of plasma-processing parameters, i.e., discharge type, duration and nature of working gas [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Plasma Treatment of Poly(ethylene terephthalate) Films and Chitosan Deposition: DC- vs. AC-Discharge

et al. 2020

View full text Add to dashboard Cite

Plasma treatment is one of the most promising tools to control surface properties of materials tailored for biomedical application. Among a variety of processing conditions, such as the nature of the working gas and time of treatment, discharge type is rarely studied, because it is mainly fixed by equipment used. This study aimed to investigate the effect of discharge type (direct vs. alternated current) using air as the working gas on plasma treatment of poly(ethylene terephthalate) films, in terms of their surface chemical structure, morphology and properties using X-ray photoelectron spectroscopy, scanning electron microscopy, atomic force microscopy and contact angle measurements. The effect of the observed changes in terms of subsequent chitosan immobilization on plasma-treated films was also evaluated. The ability of native, plasma-treated and chitosan-coated films to support adhesion and growth of mesenchymal stem cells was studied to determine the practicability of this approach for the biomedical application of poly(ethylene terephthalate) films.

show abstract

Section: Introductionmentioning

confidence: 99%

Plasma Treatment of Poly(ethylene terephthalate) Films and Chitosan Deposition: DC- vs. AC-Discharge

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Plasma is a partially or totally ionized gas formed under specific conditions and composed of ions, electrons, and free radicals, which may potentially interact with contact materials [1]. Plasma treatment is an extremely powerful method for material surface modification, as it offers the possibility to modify material surface properties, without altering their bulk characteristics, and can be applied to a huge variety of polymers, metals, and ceramics.…”

Section: Introductionmentioning

confidence: 99%

Plasma Treatment of Polymer Powder as an Effective Tool to Functionalize Polymers: Case Study Application on an Amphiphilic Polyurethane

et al. 2019

View full text Add to dashboard Cite

Plasma treatment is a widely applied, easy, fast, and highly reproducible surface modification technique. In this work powder plasma treatment was exploited to expose carboxylic groups along the backbone of a water soluble polymer. Specifically, a custom-made amphiphilic poly(ether urethane) containing Poloxamer® 407 blocks (Mw = 54,000 Da) was first synthesized and its powders were plasma treated in the presence of Acrylic Acid vapor. To maximize –COOH group exposure while preventing polymer degradation, different Ar gas flow rates (i.e., 10, 30, and 50 sccm) were investigated. Upon gas flow increase, significant polymer degradation was observed, with a 35% molecular weight reduction at 50 sccm Ar flow rate. On the other hand, the highest number of exposed carboxylic groups (5.3 × 1018 ± 5.5 × 1017 units/gpolymer) was obtained by setting gas flow at 10 sccm. Hence, a gas flow of 10 sccm turned out to be the best set-up to maximize –COOH exposure while preventing degradation phenomena. Additionally, upon plasma treatment, no detrimental effects were observed in the thermoresponsiveness of polymer aqueous solutions, which was ensured by Poloxamer® 407 blocks. Therefore, the newly developed technology here applied on an amphiphilic poly(ether urethane) could pave the way to the tailored design of a plethora of different multifunctional hydrogels.

show abstract

“…Strategies for functionalization of biomedical polymers include topography (surface graft polymerization or thin film deposition by chemical vapor deposition (CVD)) and immobilization (such as proteins, nucleic acids, and carbohydrates) [154]. It has been reported that plasma treatment allows precisely controlling the chemical functionalization and morphology of the surface of biodegradable and nonbiodegradable polymers, which results in coating with good stability and better compatibility with the biomolecules and host cells in liquid media [146,155,156]. Some biocompatible polymers exhibit a hydrophobic surface, which impairs the desired cellular response.…”

Section: Biomedical Polymeric Substratesmentioning

confidence: 99%

Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces

Galindo

Chai

Tagaya

2019

Journal of Nanomaterials

View full text Add to dashboard Cite

Bone is an organic-inorganic composite with the ability to regenerate itself. Thus, several studies based on artificial organic-inorganic interface sciences have been tried to develop capable materials for effective regenerative bone tissues. Hydroxyapatite nanoparticles (HAp NPs) have extensively been researched in bone tissue engineering due to the compositional and shape similarity to the mineral bone and excellent biocompatibility. However, HAp alone has low mechanical strength, which limits its applications. Therefore, HAp NPs have been deposited on the biocompatible polymer matrix, obtaining composites with the enhanced mechanical, thermal, and rheological properties and with higher biocompatibility and bioactivity. For developing new biomedical applications, polymer-HAp interfacial interactions that provide biofusion should be investigated. This paper reviewed common coating techniques for obtaining HAp NPs/polymer fusion interfaces as well as in vitro studies of interfacial interactions with proteins and cells, demonstrating better biocompatibility. Studies based on interfacial interactions between biomolecules and HAp NPs were highlighted, and how these interactions can be affected by specific protein preadsorption was also summarized.

show abstract

Plasma treatment as an efficient tool for controlled drug release from polymeric materials: A review

Cited by 77 publications

References 155 publications

Plasma Treatment of Poly(ethylene terephthalate) Films and Chitosan Deposition: DC- vs. AC-Discharge

Plasma Treatment of Poly(ethylene terephthalate) Films and Chitosan Deposition: DC- vs. AC-Discharge

Plasma Treatment of Polymer Powder as an Effective Tool to Functionalize Polymers: Case Study Application on an Amphiphilic Polyurethane

Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces

Contact Info

Product

Resources

About