Plasma treatment effects on bulk properties of polycaprolactone nanofibrous mats fabricated by uncommon AC electrospinning: A comparative study

Sivan, Manikandan; Madheswaran, Divyabharathi; Asadian, Mahtab; Cools, Pieter; Thukkaram, Monica; Voort, Pascal Van Der; Morent, Rino; Geyter, Nathalie De; Lukáš, David

doi:10.1016/j.surfcoat.2020.126203

Cited by 39 publications

(20 citation statements)

References 55 publications

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“…[ 10 ] However, despite the well‐studied benefits of plasma for improving the adhesion of cells onto PCL fibers, [ 11,12 ] exposure to plasma may also contribute to the accelerated oxidative degradation of scaffolds, limiting longevity and mechanical stability in vitro and in vivo. [ 13 ] This is of particular concern when considering MEW scaffolds, owing to their order‐of‐magnitude higher fiber surface‐to‐volume ratio, which significantly increases their susceptibility to degradation via surface modifications compared to fused deposition modelling (FDM)‐printed scaffolds with the same porosity (Figure S1 and Table S1, Supporting Information).…”

Section: Introductionmentioning

confidence: 99%

Degradation of Melt Electrowritten PCL Scaffolds Following Melt Processing and Plasma Surface Treatment

Paxton

Tuten

et al. 2021

Macromol. Rapid Commun.

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Melt electrowriting (MEW) has been widely used to process polycaprolactone (PCL) into highly ordered microfiber scaffolds with controllable architecture and geometry. However, the integrity of PCL during specific processes involved in routine MEW scaffold development has not yet been thoroughly investigated. This study investigates the impact of MEW processing on PCL following exposure to high temperatures required for melt extrusion as well as atmospheric plasma, a widely used surface treatment for improving MEW scaffold hydrophilicity. The change in polymer molecular weight and melt temperature is characterized, in comparing unprocessed and processed samples, in addition to analysis of the mechanical and surface properties of the scaffolds. No significant difference in the molecular weight or mechanical properties of the PCL scaffolds is evident following 5 days of cyclic heating to 90 °C. Exposure to plasma for up to 5 min significantly increased hydrophilicity and surface adhesion force, characterized via contact angle and atomic force microscope, however, significant polymer degradation occurred evidenced by increased brittleness of the scaffolds. This study demonstrates the degradation of PCL following fabrication via MEW and surface treatment to guide the optimization of scaffold development for subsequent applications in tissue engineering and biofabrication.

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Section: Introductionmentioning

confidence: 99%

Degradation of Melt Electrowritten PCL Scaffolds Following Melt Processing and Plasma Surface Treatment

Paxton

Tuten

et al. 2021

Macromol. Rapid Commun.

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“…[ 14,186–189 ] Cold plasma or non‐equilibrium treatment at low temperatures has been used for the surface treatment of thermosensitive materials such as polymeric nanofibers and biomaterials. [ 190 ] The main parameters that contribute to the surface modification are the type of gas [ 191 ] (air, oxygen, argon, and nitrogen) generating different reactive groups on the surface, pressure, [ 192 ] temperature, [ 193 ] and the treatment time. [ 194 ] The use of plasma treatment allows temporary modifications within a few nanometers of the surface, with gradual loss of effect, maintaining properties of the material bulk.…”

Section: Post‐modification Methods For Micro/nanofibermentioning

confidence: 99%

Tailoring the Surface Properties of Micro/Nanofibers Using 0D, 1D, 2D, and 3D Nanostructures: A Review on Post‐Modification Methods

Schneider

Facure

Chagas

et al. 2021

Adv Materials Inter

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Micro‐ and nanofibers produced by electrospinning and solution blow spinning (SBS) are highly suitable platforms for diverse applications due to their advantageous properties, including the high surface area to volume ratio, high porosity, and flexibility. To render them additional functionalities, distinct pre‐ or post‐modification processes have been proposed for modifying such micro‐ and nanofibers with 0D, 1D, 2D, and 3D nanostructures. The pre‐modification requires the addition of 0D–3D nanostructures (or their precursors) into the polymeric phase before the spinning process, which can demand laborious solubilization and requires changes in experimental spinning parameters, with impact on morphology, spinnability, and properties. Post‐modification methods, on the other hand, enable the fabrication of composite fibers without the need to optimize the spinning parameters, allowing a simple and efficient surface modification. Herein, recent advances on post‐modification methods of spun fibers, including wet chemistry, grafting, crosslinking, click chemistry, oxidations, hydrolysis and reduction strategies, dip‐coating, layer‐by‐layer, electro/air‐spray, atomic layer deposition, and plasma techniques aiming at the surface functionalization with 0D–3D nanostructures are surveyed. Recent results, trends, and challenges on the application of such surface‐modified fibers for environmental, industrial, and medical applications, including as adsorbent and filtering membranes, catalysts for pollutants degradation, and wearable sensors are examined.

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“…Currently, there are only a few publications that deal with this technology. In recent publications, several polymers have been spun using AC electrospinning, such as gelatin, 18 polyamide 6, 19 poly(vinyl alcohol), 20 poly(ethylene oxide), 21 polyacrylonitrile, 22 or polycaprolactone, 23 which we have also addressed in this study.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a Composite Scaffold from Polycaprolactone and Hydroxyapatite Particles by Means of Alternating Current Electrospinning

et al. 2021

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This research involved the production of polycaprolactone fiber layers via the alternating current electrospinning method. To construct the micro/nanofiber scaffold, mixtures of two molecular weight solutions, M n 45 000 and M n 80 000, were spun in differing proportions in a solvent system containing acetic acid, formic acid, and acetone in a ratio of 1:1:1. The composite fiber materials with hydroxyapatite particles were prepared from a solution that combined the different molecular weight solutions at a ratio of 1:3. The study resulted in the preparation of fiber layers containing 0, 5, 10, and 15% (wt) hydroxyapatite particles from the dry mass of the polycaprolactone. The strength, wettability, and surface energy of the composite materials were examined, and the results demonstrated that hydroxyapatite affects the fiber diameters, strength, and surface energy and, thus, the wettability of the fiber layers. The fibrous layers produced were further tested for cytotoxicity and cell viability and proliferation. The results obtained thus strongly indicate that the resulting bulky micro/nanofiber layers are suitable for further testing with a view to their eventual application in the field of bone tissue engineering.

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Plasma treatment effects on bulk properties of polycaprolactone nanofibrous mats fabricated by uncommon AC electrospinning: A comparative study

Cited by 39 publications

References 55 publications

Degradation of Melt Electrowritten PCL Scaffolds Following Melt Processing and Plasma Surface Treatment

Degradation of Melt Electrowritten PCL Scaffolds Following Melt Processing and Plasma Surface Treatment

Tailoring the Surface Properties of Micro/Nanofibers Using 0D, 1D, 2D, and 3D Nanostructures: A Review on Post‐Modification Methods

Preparation of a Composite Scaffold from Polycaprolactone and Hydroxyapatite Particles by Means of Alternating Current Electrospinning

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