Plasma tumour necrosis factor-α and early carotid atherosclerosis in healthy middle-aged men

Skoog, Tiina; Dichtl, Wolfgang; Boquist, Susanna; Skoglund‐Andersson, C.; Karpe, Fredrik; Tang, Rong; Bond, M. Gene; Fairé, Ulf dé; Nilsson, Jan; Eriksson, Per; Hamsten, Anders

doi:10.1053/euhj.2001.2805

Cited by 242 publications

(169 citation statements)

References 30 publications

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“…In particular when HAECs were incubated with fenofibrate in the presence of oxidized LDL the effect of the medication was reversed (Figure 1 and Figure 4). While it is impossible to replicate the atheromatous environment in vitro, both TNF-α and oxidized LDL have been demonstrated within atherosclerosis and shown to modulate TM expression, supporting the relevance of these studies [31][32][33][34][35]. There are a number of other mechanisms which may account for the inter-sample variation in response to PPAR ligand incubation in this study.…”

Section: Discussionsupporting

confidence: 73%

Modulation of endothelial cell thrombomodulin by PPAR ligands — Variation according to environment

Mangan

Clancy

Golledge

2008

Thrombosis Research

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Section: Discussionsupporting

confidence: 73%

Modulation of endothelial cell thrombomodulin by PPAR ligands — Variation according to environment

Mangan

Clancy

Golledge

2008

Thrombosis Research

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“…Resident B cells produce IL-6 and TNF-a. Elevated serum levels of these cytokines are generally found in patients having a poor prognosis or more severe arterial lesions (55,56). Animal models designed to decipher the role of IL-6, TNF-a, and GM-CSF in atherosclerosis have not yet been fully conclusive because experimental settings (feeding diet, location of the lesions, and sex of the animals) largely determine the outcome of lesion evolution (57)(58)(59)(60)(61)(62)(63)(64).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Resident B Cells of Vascular Walls in Human Atherosclerotic Patients

Hamze

Desmetz

Berthe

et al. 2013

The Journal of Immunology

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Animal models of atherosclerosis suggest that B cells have contradictory protective or proatherogenic effects that are also subset and context dependent. To further understand the pathophysiology of human atheroma, we characterized local Ig production and functional properties of resident B cells in human arterial lesions. Ig repertoires were analyzed by RT-PCR in carotid endarterectomy samples. Cytokine, differentiation marker and transcription factor mRNA expression was studied on arterial wall lymphocytes isolated by laser capture microdissection. Ig sequence analysis revealed that individual samples each contained a limited number of B cell clones. Functional α and γ mRNAs made up the majority of H chain mRNAs in the adventitia. Clonal evolution of Ig V regions, expression of activation-induced cytidine deaminase, clonal H chain switch, and an inverted λ/κ ratio of Ig L chain usage indicated that a local differentiation process was taking place in arterial walls. Clonotypic markers revealed different plaque and adventitia Ig repertoires and a B cell recirculation between adventitia and draining lymph nodes. Microdissected mononuclear cells had an activated phenotype expressing IL-6, GM-CSF, and TNF-α, whereas IL-2, IL-4, IL-10, M-CSF, and IFN-γ were not detected. Adventitial oligoclonal resident B cells of atherosclerotic patients are mainly mature B2 (conventional) CD20− plasmablasts lacking markers of terminal differentiation to plasma cell (CD138 and Blimp-1). They present hallmarks of Ag-driven maturation and could act on inflammation and disease progression directly or by promoting polarization of other immune cells.

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“…Recent studies in healthy men showed that smoking status had no effect on TNF-a concentrations. 32,34 Macrophage cells secrete more TNF-a in the presence of lower concentrations of smokeless tobacco than in the presence of higher concentrations. 35 Vayssier et al 36 also observed, as we did, that tobacco was related with decreased TNF-a concentrations, and concluded that it could abolish TNF-a cellular release.…”

Section: Discussionmentioning

confidence: 99%

Biological variations, genetic polymorphisms and familial resemblance of TNF-α and IL-6 concentrations: STANISLAS cohort

et al. 2004

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Cytokines are involved in the development of several inflammatory diseases and atherosclerosis. Their variations in healthy individuals are not well defined. The aims of this study were: firstly, to identify factors affecting biological variation of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-a); secondly, to study their family resemblance; and thirdly, to evaluate the effect of two TNF-a (À308G/A and À238G/A) and two IL-6 polymorphisms (174G/C and À572G/C) on their corresponding circulating levels. A total of 171 healthy families selected from the STANISLAS cohort were studied. Age was negatively related to TNFa concentrations in offspring only (both sons and daughters). Additionally, IL-6 and TNF-a levels were differently influenced by gender, white blood cells, tobacco consumption, and HDL-cholesterol level. A weak significant familial resemblance for TNF-a concentration was observed in siblings only. There was no significant familial resemblance for IL-6 levels. The TNF-a À308A allele was associated with decreased TNFa concentrations in both offspring aged less than 18 and males without overweight (BMIo25 kg/m 2 ). Fathers carrying the IL-6 À174CC genotype had higher IL-6 levels than those with the IL-6 À174G allele. Parents with the IL-6 À572GG genotype had higher IL-6 concentrations than the C allele carriers. In this sample of healthy families, plasma levels of IL-6 and TNF-a were differently affected by biological parameters including age, gender and smoking, and the impact of their respective polymorphisms was influenced by gender, age and BMI.

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Plasma tumour necrosis factor-α and early carotid atherosclerosis in healthy middle-aged men

Abstract: The plasma TNF-alpha concentration is associated with degrees of early atherosclerosis and correlates with metabolic and cellular perturbations that are considered important for the vascular process.

Cited by 242 publications

References 30 publications

Modulation of endothelial cell thrombomodulin by PPAR ligands — Variation according to environment

Modulation of endothelial cell thrombomodulin by PPAR ligands — Variation according to environment

Characterization of Resident B Cells of Vascular Walls in Human Atherosclerotic Patients

Biological variations, genetic polymorphisms and familial resemblance of TNF-α and IL-6 concentrations: STANISLAS cohort

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