Plasma Vitamin C, but Not Vitamin E, Is Associated With Reduced Risk of Heart Failure in Older Men

Wannamethee, S. Goya; Bruckdorfer, K. R.; Shaper, A G; Papacosta, Olia; Lennon, Lucy; Whincup, Peter H.

doi:10.1161/circheartfailure.112.000281

Cited by 32 publications

(21 citation statements)

References 31 publications

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“…In cross-sectional studies by Wannamethee et al 34 evaluating the relationship between inflammatory markers and blood levels of vitamin C, the plasma level of vitamin C was found to be associated with a significant reduction in risk of heart failure in men with and without pre-existing myocardial infarction. The inverse association between plasma vitamin C and heart failure in men was explained by traditional risk factors involving reduction of CRP.…”

Section: Discussionmentioning

confidence: 97%

Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial

Ellulu¹,

Rahmat²,

Patimah³

et al. 2015

DDDT

164

100

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BackgroundObesity is well associated as being an interfering factor in metabolic diseases such as hypertension and diabetes by increasing the secretion of proinflammatory markers from adipose tissue. Having healthy effects, vitamin C could work as an anti-inflammatory agent through its antioxidant capacity.RegistrationRegistration number: FPSK_Mac [13]04.ObjectiveThe aim of the study reported here was to identify the effect of vitamin C on reducing the levels of inflammatory markers in hypertensive and/or diabetic obese adults.Subjects and methodsSixty-four obese patients, who were hypertensive and/or diabetic and had high levels of inflammatory markers, from primary health care centers in Gaza City, Palestine, were enrolled into one of two groups in an open-label, parallel, randomized controlled trial. A total of 33 patients were randomized into a control group and 31 patients were randomized into an experimental group. The experimental group was treated with 500 mg vitamin C twice a day.ResultsIn the experimental group, vitamin C significantly reduced the levels of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), fasting blood glucose (FBG), and triglyceride (TG) after 8 weeks of treatment (overall: P<0.001); no changes appeared in total cholesterol (TC). In the control group, there were significant reductions in FBG and TG (P=0.001 and P=0.026, respectively), and no changes in hs-CRP, IL-6, or TC. On comparing the changes in the experimental group with those in the control group at the endpoint, vitamin C was found to have achieved clinical significance in treating effectiveness for reducing hs-CRP, IL-6, and FBG levels (P=0.01, P=0.001, and P<0.001, respectively), but no significant changes in TC or TG were found.ConclusionVitamin C (500 mg twice daily) has potential effects in alleviating inflammatory status by reducing hs-CRP, IL-6, and FBG in hypertensive and/or diabetic obese patients.

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Section: Discussionmentioning

confidence: 97%

Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial

Ellulu¹,

Rahmat²,

Patimah³

et al. 2015

DDDT

164

100

View full text Add to dashboard Cite

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“…15,16 Although no single marker that includes vitamin C intake can totally reflect fruit intake, diets high in vitamin C are associated with the quality of the diet and decreased risk for several medical conditions, including obesity and heart failure. 17,18 The lower intake of vitamin C and vegetables in the baby boomer generation may represent a concerning pattern despite there being no difference in reported total fruit intake compared with the previous generation of middle-aged adults.…”

Section: Discussionmentioning

confidence: 99%

Intake of Key Chronic Disease–Related Nutrients among Baby Boomers

King¹,

Xiang²,

Brown³

2014

Southern Medical Journal

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Objectives The dietary habits of baby boomers (people born between 1946 and 1964) undoubtedly will have a substantial impact on their future health; however, dietary information regarding the intake of key chronic disease–related nutrients is lacking for this generation. The objective of this study was to compare the dietary intake of key chronic disease–related nutrients of the baby boomer generation with the previous generation of middle-aged adults. Methods National cross-sectional study comparison analyzing data from the National Health and Nutrition Examination Survey (NHANES) including NHANES III (1988–1994) and the NHANES for 2007–2010, focused on adult respondents ages 46 to 64 years who were not institutionalized at the time of each survey. The two cohorts were compared with regard to dietary intake of key nutritional components. The main outcome measures were intake of total calories, sodium, cholesterol, fat, fruits, vegetables, vitamin C, water, and fiber. Results The baby boomers’ average daily intake of nutrients exceeded that of the previous generation of middle-aged adults for total calories (2118/1999), total fat (82/76 g), sodium (3513/3291 mg), and cholesterol (294/262 g; all P < 0.001). The intake of vitamin C (105/89 g), water (1208/1001 g), and vegetables (199/229 g) was less than that of the previous generation (P < 0.001), and the dietary intake of fruit and fiber was unchanged. In regression analyses, dietary changes remained significant after controlling for age, race, sex, and socioeconomic status (all P < 0.01). Conclusions The study findings document higher dietary intake of key chronic disease–related nutrients along with reduced vegetable intake among baby boomers compared with the previous generation of middle-aged adults. These findings are indicative of a diet that may contribute to increased rates of chronic disease among individuals in this age group.

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“…superoxide, peroxynitrite and hypochlorous acid) might have attenuated the positive effects of vitamin E. Likewise, in a clinical trial, vitamin C had no effect on the prevention of incident HF and data are lacking on its use for the treatment of HF. 10 Hyperuricaemia is associated with an increased risk of new-onset HF in patients with hypertension or coronary artery disease. Also, higher uric acid levels confer a greater risk of adverse outcomes in patients with established HF.…”

Section: Introductionmentioning

confidence: 99%