Plasma Vitamins, Amino Acids, and Renal Function in Postexercise Hyperhomocysteinemia

Venta, Rafael; Cruz, E.; Valcárcel, Gracia; Cepeda, Nicolás Terrados

doi:10.1249/mss.0b013e31819e02f2

Cited by 28 publications

(39 citation statements)

References 38 publications

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“…These authors suggested that the high intensity sustained by the runners comparing to the 100 km run and mountain bike race, can have more rest periods during trials, being a possible answer of this response. In contrast, other research studies including different intensities showed that the tHcy increase is independent of the intensity of the exercise [11,24] or type of exercise [22]. Sotgia et al [21], who compared athletes and non-athletes subjects, found no changes in tHcy after acute exercise but a decrease in the Homocysteine reduced form [21].…”

Section: Acute Effect Of Exercise On Thcy Concentrationsmentioning

confidence: 92%

What do we know about homocysteine and exercise? A review from the literature

Maroto-Sánchez

López-Torres

Palacios

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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High total homocysteine (tHcy) concentrations contribute to an increased risk of cardiovascular diseases and neurodegenerative disorders. Several investigations have focused on the effect of exercise on tHcy concentrations, but results remain controversial. The differences among the methodologies in the investigations make difficult the interpretation of results. This review differentiates the effects of exercise on tHcy and establishes the relation with the implicated biomarkers on tHcy metabolism related to exercise. The electronic database MEDLINE (http://www.ncbi.nlm.nih.gov) was used for searching studies published between years 2002 and 2015. 'Homocysteine', 'Training ', 'Exercise', 'Physical Activity' as well as combinations out of these terms were entered in the database. Articles were grouped in: 1) Acute effect of exercise on tHcy, 2) chronic exercise and tHcy, 3) relationship of physical activity (PA) level and cardiorespiratory fitness with tHcy, and 4) biomarkers related to tHcy and exercise. From a total of 30 articles, most of the studies analyzing the acute effect of exercise showed an increase on tHcy concentrations. Studies analyzing the chronic effect on tHcy concentrations showed contradictory results and no consensus exists probably due to the differences in the methodology, exercise interventions and participants characteristics. Low cardiorespiratory fitness seems to be associated with high tHcy; in contrast, the relation of PA levels and tHcy needs further research. Regarding biomarkers related to tHcy and exercise, some studies showed an increase of folate, vitamin B 12 , and creatine after acute exercise that could to be due to requirement of protein turnover and an increased metabolic demand of vitamin-B.

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Section: Acute Effect Of Exercise On Thcy Concentrationsmentioning

confidence: 92%

What do we know about homocysteine and exercise? A review from the literature

Maroto-Sánchez

López-Torres

Palacios

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Increased plasma Hcy concentrations have been observed in several studies using different exercise intensities and modalities (Herrmann et al 2003a, b;König et al 2003;Real et al 2005;Venta et al 2009). However, Venta et al (2009) reported that the exact mechanism by which plasma Hcy concentrations increase after acute exercise is unknown. Also, the effects of creatine supplementation on Hcy levels after acute aerobic and anaerobic exercise are unknown.…”

Section: Introductionmentioning

confidence: 95%

Creatine supplementation reduces increased homocysteine concentration induced by acute exercise in rats

et al. 2011

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The aim of this study was to evaluate the effect of creatine supplementation on homocysteine (Hcy) metabolism after acute aerobic and anaerobic exercise. A total of 112 Wistar rats were divided into four groups: aerobic exercise (A), aerobic exercise plus creatine supplementation (ACr), anaerobic exercise (An), and anaerobic exercise plus creatine-supplemented (AnCr). Creatine supplementation consisted of the addition of 2% creatine monohydrate to the diet. After 28 days, the rats performed an acute moderate aerobic exercise bout (1 h swimming with 4% of total body weight load) or an acute intense anaerobic exercise bout (6 × 30-s vertical jumps into the water with a 30-s rest between jumps, with 50% of total body weight load). The animals were killed before (pre) and at 0, 2, and 6 h (n = 8) after acute exercise. Plasma Hcy concentration increased significantly (P < 0.05) up to 2 h after anaerobic exercise (An group: pre 8.7 ± 1.2, 0 h 13.2 ± 2.3, 2 h 13.5 ± 4.2, and 6 h 12.1 ± 2.2, μmol/l). The same did not occur in acute aerobic exercised animals. Nevertheless, creatine supplementation significant decreased (P < 0.05) homocysteine concentration independent of exercise intensity (AnCr group: pre 17%, 0 h 80%, 2 h 107%, and 6 h 48%; ACr group: pre 17%, 0 h 19%, 2 h 28%, and 6 h 27%). Increased S-adenosylhomocysteine was also found in the An group. In conclusion, acute intense anaerobic exercise increased plasma Hcy concentration. On the other hand, creatine supplementation decreased plasma Hcy independent of exercise intensity.

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“…The results of (17) showed that higher plasma concentrations of Hcy after acute exercise are independent of vitamin status, or amino acid metabolic stress but could be related to potential changes in renal function.…”

Section: Discussionmentioning

confidence: 98%

Relationship between Folic Acid Supplementation, Serum Homocysteine and Markers of Kidney Function in Male Albino Rats

2016

IJSR

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Increased serum homocysteine (Hcy) can induce kidney diseases and can play a role in renal disorders. The purpose of the present study therefore was to investigate the relationship between serum hyperhomocysteinemia (HHcy) induced by methionine administration, folic acid and kidney functions. The relationship between total homocysteine (tHcy) and outcomes has not been investigated in patients with chronic kidney disease. The present study was designed to induce hyperhomocysteinemia (HHcy) in male rats. Also, to evaluate, the effect of (HHcy) as a risk factor for kidney disorder and folic acid supplementation on serum levels of Hcy, urea, uric acid, creatinine and alkaline phosphatase. In this work 50 male albino rats were used and divided into five groups. The first served as control., the second and third group received two different doses of L-methionine., the fourth and fifth group received fortified diet with folic acid powder plus L-methionine. The results showed that homocysteine levels in rats received low and high doses of methionine were higher than in the control group, and increased urea in rats treated with high dose of methionine only, while uric acid and creatinine level showed insignificant changes in rats treated with both doses of methionine. Alkaline phosohatases activity significantly increased in low and high dose treated rats compared to control group. Folic acid supplementation induced significant decrease in homocysteine level in rats treated with high dose of methionone while low dose keeps homocysteine within normal value.As regard to kidney functions, supplementation of folic acid with low dose of methionine leading to significant decrease in serum urea and uric acid concentration while, when folic acid added to high dose of methionine keep its concentration within the normal value.Creatinine and alkaline phosphatase level significantly increased in folic acid treated rats with high dose of methionine, but an alkaline phosphatase activity significantly increased in folic acid treated rats with low and high dose of methionine. A positive correlation was seen between the activities of alkaline phosphatase in serum and HHcy rats. It can be concluded that hyperhomocysteinemia may be an additional risk factor for renal failure and dietary supplementation with folic acid blocking the activity of homocysteine and may be considered as a therapeutic possibility in patients with renal disorders. Also, plasma Hcy and folic acid measurement may be useful in the evaluation of renal disorders. More studies are necessary to pinpoint the precise mechanisms that lead to hyperhomocysteinemia in renal failure. This should lead to optimal treatment and, ultimately, to the prevention of cardiovascular complications in this vulnerable patient group.

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Plasma Vitamins, Amino Acids, and Renal Function in Postexercise Hyperhomocysteinemia

Cited by 28 publications

References 38 publications

What do we know about homocysteine and exercise? A review from the literature

What do we know about homocysteine and exercise? A review from the literature

Creatine supplementation reduces increased homocysteine concentration induced by acute exercise in rats

Relationship between Folic Acid Supplementation, Serum Homocysteine and Markers of Kidney Function in Male Albino Rats

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