Plasma β-amyloid peptides levels: A pilot study in bipolar depressed patients

Piccinni, Armando; Origlia, Nicola; Veltri, Antonello; Vizzaccaro, Chiara; Marazziti, Donatella; Catena-Dell’Osso, Mario; Conversano, Ciro; Moroni, Ilenia; Domenici, Luciano; Dell’Osso, Liliana

doi:10.1016/j.jad.2011.12.042

Cited by 35 publications

(22 citation statements)

References 36 publications

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“…Alternatively, Aβ-mediated neurodegenerative processes could be triggered by recurrence of affective episodes representing an epiphenomenon in all patients with mood disorders. Interestingly, in both this study and in another of our group [22] a positive correlation was detected between the Aβ40/Aβ42 ratio and the number of affective episodes, while highlighting how the changes of blood Aβ levels could characterize a subgroup of bipolar patients with worse illness course.…”

Section: Discussionsupporting

confidence: 70%

“…In another study [21], depressed patients showed an enhanced Aβ40/Aβ42 ratio, but no differences in Aβ42 levels, when compared with age-matched control subjects. In our recent study on bipolar depressed patients, a negative correlation was found between Aβ42 plasma levels and duration of illness, and a positive one between the Aβ40/Aβ42 ratio and the number of affective episodes [22]. …”

Section: Introductionmentioning

confidence: 99%

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Plasma Amyloid-β Levels in Drug-Resistant Bipolar Depressed Patients Receiving Electroconvulsive Therapy

et al. 2013

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Aims: Alterations of plasma amyloid-β (Aβ) peptides have been related to a high risk for cognitive impairment and dementia. The present study aimed to measure plasma Aβ peptides (Aβ40, Aβ42) and the Aβ40/Aβ42 ratio in a sample of drug-resistant bipolar depressed patients, as well as to explore the possible correlation between biological parameters and clinical changes along an electroconvulsive therapy (ECT) course. Methods: Aβ40 and Aβ42 were measured by means of an ELISA assay in 25 drug-resistant bipolar depressed patients before (T0) and 1 week after (T1) the end of ECT. The patients were clinically evaluated by means of the Hamilton Rating Scale for Depression, 21-item (HRSD-21), the Mini-Mental State Examination, and the Clinical Global Impressions-Severity of Illness Scale. Results: Plasma Aβ levels and the Aβ40/Aβ42 ratio were similar at T0 and T1. The Aβ40/Aβ42 ratio correlated positively with the HRSD total score at both T0 and T1. At T0, a negative correlation was found between the Aβ40/Aβ42 ratio and the improvement of depressive and cognitive symptoms. Moreover, remitters (n = 9; HRSD ≤10) showed a significantly lower Aβ40/Aβ42 ratio at T0 than nonremitters. Conclusion: The present data suggest that a low Aβ40/Aβ42 ratio might characterize a subgroup of depressed patients who respond to ECT, while higher values of this parameter seem to be typical of more severe cases of patients with cognitive impairment.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Plasma Amyloid-β Levels in Drug-Resistant Bipolar Depressed Patients Receiving Electroconvulsive Therapy

et al. 2013

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“…Further, even though previous studies in younger adults with BD have shown an association between poorer cognitive function and both elevated serum amyloid levels (Piccinni et al ., ) and presence of Apolipoprotein‐ε4 (Soeira‐de‐Souza et al ., ), our data suggest that cognitive impairment in late‐life BD is not likely due to comorbid Alzheimer's disease or amnestic mild cognitive impairment. A recent study demonstrated that regional WMH burden, but not hippocampal volume, is associated with increased rates of Alzheimer's disease (Brickman et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Neuroimaging and neurocognitive abnormalities associated with bipolar disorder in old age

Rej

Butters

Aizenstein

et al. 2013

Int J Geriat Psychiatry

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Objectives Cognitive dysfunction is prevalent in older adults with bipolar disorder (BD). High white matter hyperintensity (WMH) burden, a marker of white matter disease, detected on T2/fluid-attenuated inversion recovery brain magnetic resonance imaging (MRI) has been consistently reported in BD across all age ranges, including older adults. Yet, whether high WMH burden is related to the excess cognitive impairment present in older adults with BD is unknown. Therefore, we examine whether higher WMH burden is related to worse cognitive function in older adults with BD. Methods This is a cross-sectional study of 27 non-demented BD patients aged ≥50 years and 12 similarly aged mentally healthy comparators (controls). Subjects underwent both brain MRI and comprehensive neurocognitive assessment. We employed correlational analyses to evaluate the burden of WMH and the relationship between WMH and cognitive function. Results Although BD subjects had worse performance in all cognitive domains, BD subjects had less total WMH burden (t[13.4] = −3.57, p = 0.003). In control subjects, higher WMH was related to lower global cognitive function (ρ= −0.57, n= 12, p = 0.05). However, WMH did not correlate with neuropsychological performance in BD subjects. Further, BD and control subjects did not differ with respect to total gray and hippocampal volumes. Conclusions Cognitive dysfunction in late-life BD does not appear to be due primarily to processes related to increased WMH or reduced gray matter volume. Future longitudinal studies should examine other potential neuroprogressive pathways such as inflammation, mitochondrial dysfunction, serum anticholinergic burden, and altered neurogenesis.

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“…Lower plasma levels of Aβ-42 and higher Aβ40/Aβ42 ratios were found in a sample of patients with bipolar disorder or depression. The findings indicate a possible disturbance of the amyloid turnover also in bipolar disorder [31]. …”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal fluid microglia and neurodegenerative markers in twins concordant and discordant for psychotic disorders

Johansson

Jakobsson

Fortgang

et al. 2016

Eur Arch Psychiatry Clin Neurosci

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Schizophrenia and bipolar disorder are debilitating psychiatric disorders with partially shared symptomatology including psychotic symptoms and cognitive impairment. Aberrant levels of microglia and neurodegenerative cerebrospinal fluid (CSF) markers have previously been found in schizophrenia and bipolar disorder. We aimed to analyze familial and environmental influences on these CSF markers and their relation to psychiatric symptoms and cognitive ability. CSF was collected from 17 complete twin pairs, nine monozygotic and eight dizygotic, and from one twin sibling. Two pairs were concordant for schizophrenia, and 11 pairs discordant for schizophrenia, schizoaffective disorder or bipolar disorder, and four pairs were not affected by psychotic disorders. Markers of microglia activation [monocyte chemoattractant protein-1 (MCP-1), chitinase 3-like protein 1 (YKL-40), and soluble cluster of differentiation 14 (sCD14)], markers of β-amyloid metabolism (AβX-38, AβX-40, AβX-42 and Aβ1-42), soluble amyloid precursor proteins (sAPP-α and sAPP-β), total tau (T-tau), phosphorylated tau (P-tau), and CSF/serum albumin ratio were measured in CSF using immunoassays. Heritability of the CSF markers was estimated, and associations to psychiatric and cognitive measurements were analyzed. Heritability estimates of the microglia markers were moderate, whereas several neurodegenerative markers showed high heritability. In contrast, AβX-42, Aβ1-42, P-tau and CSF/serum albumin ratio were influenced by dominant genetic variation. Higher sCD14 levels were found in twins with schizophrenia or bipolar disorder compared to their not affected co-twins, and higher sCD14-levels were associated with psychotic symptoms. The study provides support for a significant role of sCD14 in psychotic disorders and a possible role of microglia activation in psychosis.Electronic supplementary materialThe online version of this article (doi:10.1007/s00406-016-0759-5) contains supplementary material, which is available to authorized users.

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Plasma β-amyloid peptides levels: A pilot study in bipolar depressed patients

Cited by 35 publications

References 36 publications

Plasma Amyloid-β Levels in Drug-Resistant Bipolar Depressed Patients Receiving Electroconvulsive Therapy

Plasma Amyloid-β Levels in Drug-Resistant Bipolar Depressed Patients Receiving Electroconvulsive Therapy

Neuroimaging and neurocognitive abnormalities associated with bipolar disorder in old age

Cerebrospinal fluid microglia and neurodegenerative markers in twins concordant and discordant for psychotic disorders

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