Plasmacytoid dendritic cells suppress Th2 responses induced by epicutaneous sensitization

Lin, Jingyi; Wu, Wei-Hsin; Chen, Jau-Shiuh; Liu, I-Lin; Chiu, Hsueh-Ling; Chen, Hsi-Wen; Tsai, Tsung Han; Huang, Yamin; Wang, Li-Fang

doi:10.1111/imcb.12315

Cited by 6 publications

(4 citation statements)

References 58 publications

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“…reported that plasmacytoid DCs, mostly Langerin - DCs activated by TSLP, could induce the generation of Foxp3 + regulatory T cells, but did not induce a Th1/Th2 response. The latest study also confirmed that plasmacytoid DCs suppressed Th2 responses induced by epicutaneous sensitization, which was the most important sensitization route for AD ( 13 ). Dermal Langerin + DCs, a minor population of skin DCs, also expressed Langerin but were totally distinguished from epidemic Langerin + LCs.…”

Section: Introductionmentioning

confidence: 68%

A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis

et al. 2022

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Cutaneous dendritic cells (DCs) have been implicated in the pathogenesis of atopic dermatitis (AD). However, the specific role of different subsets of DCs has not been well defined. This study aimed to investigate the contributions of Langerhans cells (LCs), resident dermal Langerin+ DCs (r-Langerin+ dDCs), and newly infiltrated inflammatory dermal Langerin+ DCs (i-Langerin+ dDCs) in an AD mouse model induced by the topical application of MC903. The result showed that depletion of i-Langerin+ dDCs in DTR mice after multiple diphtheria toxin (DT) injection significantly reduced thymic stromal lymphopoietin (TSLP) production in lesions and skin inflammation alleviation. However, depletion of LCs or r-Langerin+ dDCs didn’t resulted in significant changes in skin inflammation of DTA or single DT injection-treated DTR mice compared with the wild-type (WT) mice. DT-treated DTR-WT chimeric mice with the depletion of bone marrow (BM)-derived i-Langerin+ dDCs resulted in markedly decreased skin inflammation than controls, while PBS-treated chimeric mice (DTR-WT) with only the depletion of r-Langerin+ dDCs showed inflammation comparable to that in WT mice. Furthermore, TSLP contributed to the upregulation of Langerin expression in BM-derived DCs and promoted the maturation of Langerin+ DCs. In summary, the present study demonstrated that the newly infiltrated inflammatory dermal Langerin+ DCs were essential for AD development and local TSLP production, and TSLP further promoted the production of BM-derived i-Langerin+ dDCs, which might maintain AD inflammation.

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Section: Introductionmentioning

confidence: 68%

A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis

et al. 2022

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“…pDCs produce high levels of IFN-ab (type I). This cytokine impairs Th2 responses by blocking the normal development of Th2 cells and production of Th2 cytokines (especially IL-5) (44,45). The reduction in circulating pDCs during active esophageal inflammation could be indicating migration of these cells to the inflamed tissue to control the inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Circulating immunome fingerprint in eosinophilic esophagitis is associated with clinical response to proton pump inhibitor treatment

Ugalde-Triviño,

Molina-Jiménez,

H-Vázquez

et al. 2024

Front. Immunol.

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ObjectivesThe aim of the study was to characterize the circulating immunome of patients with EoE before and after proton pump inhibitor (PPI) treatment in order to identify potential non-invasive biomarkers of treatment response.MethodsPBMCs from 19 healthy controls and 24 EoE patients were studied using a 39-plex spectral cytometry panel. The plasmacytoid dendritic cell (pDC) population was differentially characterized by spectral cytometry analysis and immunofluorescence assays in esophageal biopsies from 7 healthy controls and 13 EoE patients.ResultsInterestingly, EoE patients at baseline had lower levels of circulating pDC compared with controls. Before treatment, patients with EoE who responded to PPI therapy had higher levels of circulating pDC and classical monocytes, compared with non-responders. Moreover, following PPI therapy pDC levels were increased in all EoE patients, while normal levels were only restored in PPI-responding patients. Finally, circulating pDC levels inversely correlated with peak eosinophil count and pDC count in esophageal biopsies. The number of tissue pDCs significantly increased during active EoE, being even higher in non-responder patients when compared to responder patients pre-PPI. pDC levels decreased after PPI intake, being further restored almost to control levels in responder patients post-PPI.ConclusionsWe hereby describe a unique immune fingerprint of EoE patients at diagnosis. Moreover, circulating pDC may be also used as a novel non-invasive biomarker to predict subsequent response to PPI treatment.

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“…[11][12][13] Previous studies have found a significant increase in pDCs and partially activated TLR signaling pathways (TLR7/ 9, IRAK1, IRF7) in psoriasis vulgaris lesions; 14 an increase in pDCs but inactivated TLR signaling pathways in verruca vulgaris (VV) lesions. 15 Lin et al 16 found that epidermal sensitizer protein allergen (EC) is the most essential sensitization pathway in atopic dermatitis. PDCs mediate the regulation of dermal dendritic cells (dDCs) via IFN-γ and reduces Th2 responses resulting from EC sensitization.…”

Section: Discussionmentioning

confidence: 99%

The Expression of Plasmacytoid Dendritic Cells and TLR7/9-MyD88-IRAKs Pathway in Chronic Eczema Lesions

Wen¹,

Weng²,

Lu³

et al. 2023

CCID

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To investigate the expression of Plasmacytoid Dendritic Cells (pDCs) and TLR7/9-MyD88-IRAKs pathway in chronic eczema lesions. Patients and Methods: Lesional tissues and the surrounding healthy tissues were collected from 25 individuals with chronic eczema, and immunohistochemistry was used to detect and comparatively analyze the expression profile of CD123, CD2AP, toll-like receptor 7 (TLR7), toll-like receptor 9 (TLR9) along with interleukin-1 receptor-associated kinase 1 (IRAK1) and interferon regulatory factor 7 (IRF7) in signaling pathways. Results: The positive rates of CD2AP + pDC and CD123 + pDC in lesional tissues were significantly elevated compared to the surrounding healthy tissues (P < 0.05). They were distributed in both the epidermal and dermal layers of the lesional tissue, but the majority were in the dermal layer. The TLR7, TLR9, IRAK1 and IRF7 were more expressed in dermal layers of the lesional tissue with higher positive rates of expression compared to the surrounding healthy tissues (P < 0.05). IRAK1 and IRF7 were expressed in a small amount in the epidermal layer with higher positive rates of expression than in the surrounding healthy tissues (P < 0.05), while the positive rates of TLR7 and TLR9 expression in the epidermal layer were not statistically different from those in the surrounding healthy tissues (P > 0.05). Conclusion: PDC and TLR7/9-MyD88-IRAKs pathways are actively expressed in chronic eczema lesions and may be involved in pathogenesis and disease progression.

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Plasmacytoid dendritic cells suppress Th2 responses induced by epicutaneous sensitization

Cited by 6 publications

References 58 publications

A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis

A population of dermal Langerin+ dendritic cells promote the inflammation in mouse model of atopic dermatitis

Circulating immunome fingerprint in eosinophilic esophagitis is associated with clinical response to proton pump inhibitor treatment

The Expression of Plasmacytoid Dendritic Cells and TLR7/9-MyD88-IRAKs Pathway in Chronic Eczema Lesions

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