Plasmacytoid urothelial carcinoma of the bladder

Kohno, Takurou; Kitamura, Masaya; Akai, Hideyuki; Takaha, M; Kawahara, Katsunobu; Oka, Toshitsugu

doi:10.1111/j.1442-2042.2006.01338.x

Cited by 44 publications

(36 citation statements)

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“…Three large series and numerous case reports have been published. [21][22][23][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] This variant of urothelial carcinoma is considered to be a poorly differentiated neoplasm with aggressive behavior and poor prognosis. Microscopically, these tumors are diffusely infiltrative and the individual cells are often discohesive.…”

Section: Discussionmentioning

confidence: 99%

E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma

et al. 2011

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Loss of E-cadherin expression has been linked to the invasive phenotypes of a variety of neoplasms, including lobular breast cancer. The expression of E-cadherin in variants of urothelial carcinoma relative to usual-type urothelial carcinoma, maximum depth of invasion and angiolymphatic invasion has not been well characterized. A total of eight cases of micropapillary urothelial carcinoma, four cases of plasmacytoid urothelial carcinoma, two cases of urothelial carcinoma with signet ring cell differentiation and two cases of urothelial carcinoma with mixed plasmacytoid and signet ring cell differentiation, all obtained from cystectomy/cystoprostatectomy cases, were identified. In all nine cases of usual-type invasive and noninvasive high-grade urothelial carcinoma were also included in the study. Immunohistochemical staining of E-cadherin was performed in all cases. Pathological parameters including depth of invasion and presence of angiolymphatic invasion were documented. Maximum depth of invasion: In micropapillary urothelial carcinoma, extravesical extension was seen in three of eight cases; muscularis propria invasion in four of eight cases; and lamina propria invasion in one of eight cases. In plasmacytoid urothelial carcinoma, extravesical extension was observed in two of four cases, and muscularis propria invasion and lamina propria invasion in one of four cases each. In urothelial carcinoma with signet ring cell differentiation, extravesical extension and muscularis propria invasion was seen in one of two cases each. In urothelial carcinoma with mixed plasmacytoid and signet ring cell differentiation, muscularis propria invasion and lamina propria invasion was observed in one of two cases each. In usual-type high-grade urothelial carcinoma, extravesical extension was seen in six of nine cases and noninvasive in three of nine cases. In angiolymphatic invasion, micropapillary urothelial carcinoma was observed in eight of eight cases; plasmacytoid urothelial carcinoma in two of four cases; urothelial carcinoma with signet ring cell differentiation in one of two cases; and urothelial carcinoma with mixed plasmacytoid and signet ring cell differentiation in one of two cases. Usual-type high-grade urothelial carcinoma was seen in six of nine cases. E-cadherin expression: All eight cases of micropapillary urothelial carcinoma were positive for E-cadherin in the micropapillary component and adjacent usual-type urothelial carcinoma. The four cases of plasmacytoid urothelial carcinoma, two cases of urothelial carcinoma with signet ring cell differentiation and two cases of urothelial carcinoma with mixed plasmacytoid and signet ring cell differentiation were all negative for E-cadherin. All nine additional cases of usual-type high-grade urothelial carcinoma were diffusely positive for E-cadherin. E-cadherin is diffusely positive in usual-type urothelial carcinoma and micropapillary urothelial carcinoma, irrespective of pathological stage and angiolymphatic invasion. Loss of E-cadherin expression may be a marker of...

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Section: Discussionmentioning

confidence: 99%

E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma

et al. 2011

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“…Desde entonces sólo se han descrito casos sueltos y pequeñas series de hasta 7 casos [4][5][6][7][8][9][10][11][12][13] . En una serie reciente, Perez-Montiel et al 10 encuentran sólo un caso de carcinoma urotelial con fenotipo plasmocitoide parcial entre 108 carcinomas uroteliales de alto grado, lo cual confirma nuestra experiencia de una frecuencia por debajo del 1%.…”

Section: Discussionunclassified

“…El diagnóstico diferencial de esta variedad histológica de cáncer vesical incluye principalmente a los plasmocitomas que afecten secundariamente a la vejiga urinaria, y en segundo término al carcinoma urotelial de tipo linfoepitelioma, el carcinoma de células pequeñas, el rabdomiosarcoma embrionario, y el melanoma 3,12 . Para tal fin, un panel compuesto por queratinas de amplio espectro, proteína S-100, desmina, EMA y CD45 es lo apropiado.…”

Section: Casounclassified

Carcinoma urotelial plasmocitoide de vejiga urinaria. Estudio de 7 casos

Gaafar

Oiarbide

Ugalde

et al. 2008

Actas Urológicas Españolas

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RESUMENCARCINOMA UROTELIAL PLASMOCITOIDE DE VEJIGA URINARIA. ESTUDIO DE 7 CASOS Objetivo: El carcinoma urotelial plasmocitoide es una variedad rara y agresiva de carcinoma vesical que histológicamente simula un plasmocitoma y que puede ser confundido con una neoplasia hemolinfoide que afecte secundariamente a la vejiga urinaria. Hasta la fecha solo se han descrito casos aislados y series cortas de esta variante neoplásica.Pacientes y Método: Se han encontrado un total de 7 casos de carcinoma urotelial con fenotipo plasmocitoide total o parcial entre un total de 720 casos consecutivos de carcinoma urotelial de alto grado.Resultados: El 0,97% de los carcinomas vesicales uroteliales de alto grado analizados muestra morfología plasmocitoide. Todos los casos correspondieron a varones con edades comprendidas entre 58 y 75 años. Histológicamente, dos casos presentaban morfología plasmocitoide pura, mientras que en cinco de ellos el fenotipo plasmocitoide estaba combinado con áreas transicionales y/o glandulares convencionales. La inmunohistoquímica demostró en todos los casos el carácter epitelial de las áreas plasmocitoides. El comportamiento clínico fue agresivo en todos los casos, con metástasis a distancia en tres de ellos en el momento del diagnóstico y recurrencia precoz tras el tratamiento quimioterápico en cuatro.Conclusiones: En nuestra experiencia, el carcinoma urotelial plasmocitoide de vejiga urinaria es muy poco frecuente, y puede presentarse de manera pura o asociado a áreas de carcinoma vesical convencional. Es conveniente reconocer esta variedad histológica debido a las implicaciones que conlleva en el pronóstico de los pacientes.Palabras clave: Carcinoma urotelial. Fenotipo plasmocitoide. Alto grado. Pronóstico. Inmunohistoquímica. ABSTRACT PLASMACYTOID UROTHELIAL CARCINOMA OF THE URINARY BLADDER. A STUDY OF 7 CASESObjective: Plasmacytoid urothelial carcinoma is a rare and aggressive variant of bladder cancer that mimics plasmacytoma histologically and that can be confused with hemolymphoid neoplasms secondarily affecting the urinary bladder. Only single cases and short series have been described so far.Patients and Methods: Seven cases of plasmacytoid urothelial carcinoma have been found among 720 high grade urothelial carcinomas of the urinary bladder.Results: In our series, 0.97% of high grade urothelial carcinomas of the urinary bladder show plasmacytoid phenotype. All the cases were smoking males between 58 and 75 years old. Histologically, two cases showed pure plasmacytoid features, while in the other five cases the plasmacytoid phenotype was mixed with conventional transitional cell or glandular histologies. By immunohistochemistry, all the plasmacytoid areas showed fair epithelial differentiation. The clinical behaviour was aggressive in all the cases, with distant metastases at diagnosis in three cases and early tumor recurrence after chemotherapy in four of them.Conclusions: In our experience, the plasmacytoid urothelial carcinoma of the urinary bladder is a rare tumor that can also be detec...

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“…Kohno y col describieron un caso con respuesta completa mediante quimioterapia neoadyuvante con 2 ciclos de metotrexate, etopóxido, vinblastina y cisplatino 9 .…”

Section: Discussionunclassified

Variante plasmocitoide del carcinoma urotelial: a propósito de un caso

Velis¹,

Barba²,

Tienza³

et al. 2013

Anales Sis San Navarra

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REsUMEnEl carcinoma urotelial plasmocitoide es un hallazgo anatomopatológico extremadamente raro. Aportamos nuestra experiencia de un caso.Varón de 60 años con episodios de hematuria de 2 años de evolución con polaquiuria y disuria. Se evidenció un tumor realizando primero una RTU vesical cuyo diagnóstico anatomopatológico fue de carcinoma urotelial plasmocitoide, por lo que posteriormente se realizó una cisto-prostatectomía radical con derivación ileal, y tras más de dos años de evolución falleció. aBstRactPlasmacytoid urothelial carcinoma is an extremely rare pathological finding. We report our experience of one case.A 60 year old male with hematuria of two years evolution, with frequency and dysuria. A tumor was found and he received surgical treatment by TURB at first. The pathology result was a plasmacytoid urothelial carcinoma. Subsequently a radical cystectomy with urinary diversion was performed. The patient received follow-up until his death.

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Plasmacytoid urothelial carcinoma of the bladder

Cited by 44 publications

References 2 publications

E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma

E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma

Carcinoma urotelial plasmocitoide de vejiga urinaria. Estudio de 7 casos

Variante plasmocitoide del carcinoma urotelial: a propósito de un caso

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