Plasmacytoma of the Lung Associated with Nodular Deposits of Immunoglobulin

Morinaga, Soichiro; Watanabe, Hironori; Gemma, Akihiko; Mukai, Kiyoshi; Nakajima, Takashi; Shimosato, Yukío; Goya, Tomoyuki; Shinoda, Tomotaka

doi:10.1097/00000478-198712000-00010

Cited by 53 publications

(27 citation statements)

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“…Morinaga et al, have described deposits of nonamyloid light chain in a patient with an extramedullary plasmacytoma involving the left lower lobe of the lung associated with multiple lymph node and pleural nodules. Bone marrow biopsies and skeletal surveys revealed no evidence of extrathoracic disease [4]. In contrast, our first case showed deposition of amyloid with lambda light chain restriction in a patient with solitary plasmacytoma of right acetabulum.…”

Section: Discussioncontrasting

confidence: 58%

Tracheobronchial Amyloidosis- A Series of Two Cases

2014

JCDR

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Section: Discussioncontrasting

confidence: 58%

Tracheobronchial Amyloidosis- A Series of Two Cases

2014

JCDR

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“…By definition, immunohistochemical studies show monoclonal intracytoplasmic immunoglobulin expression [70,71,73]. This differentiates these cases from low-grade lymphoma, which always contains small lymphocytes and reactive plasmocytes expressing polyclonal Ig [70,71,73].…”

Section: Mucosa-associated Lymphoid Tissue Lymphomamentioning

confidence: 99%

“…Histologically, the lesions are composed solely of plasmocytes with variable degrees of cytological anomalies [70,71]. Amyloid lesions can be present [73]. By definition, immunohistochemical studies show monoclonal intracytoplasmic immunoglobulin expression [70,71,73].…”

Section: Mucosa-associated Lymphoid Tissue Lymphomamentioning

confidence: 99%

Primary pulmonary lymphoma

Cadranel¹,

Wislez²,

Antoine³

2002

Eur Respir J

339

345

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Three distinct entities are now covered by the definition of primary pulmonary clonal lymphoid proliferation. The aim of this review is to describe the pathophysiological, diagnostic, prognostic and therapeutic aspects of these three entities.Low-grade pulmonary B-cell lymphoma is the most frequent form of primary pulmonary clonal lymphoid proliferation. It arises from mucosa-associated lymphoid tissue. It is usually indolent and appears in the form of a chronic alveolar opacity. The prognosis is excellent, but treatment is controversial (simple monitoring, surgery or single-agent chemotherapy). High-grade pulmonary B-cell lymphoma is far rarer and usually occurs in individuals with an underlying disorder (e.g. immunodeficiency). The prognosis is poor and therapeutic options depend on the underlying disorder.The inclusion of lymphomatoid granulomatosis in the definition of primary pulmonary lymphomas is controversial. The clonal nature of the proliferation is very rarely demonstrated and extrapulmonary involvement is frequent (upper airways, skin, kidneys, central nervous system, etc.). The prognosis is extremely variable, with some authors reporting complete remission with steroids and cyclophosphamide and others reporting failure of combination chemotherapy. Eur Respir J 2002; 20: 750-762.

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“…The pulmonary nodules were multiple or unique and varied in size from 0.7-4 cm. An underlying haematological disease was detected in four patients: lung plasmocytoma in two patients and lymphoplasmocytic lymphoma in the other two patients [11][12][13][14]. Extrapulmonary light chain deposition was not found in these seven patients.…”

Section: Discussionmentioning

confidence: 81%

“…The possibility of lung nodules and diffuse pulmonary interstitial disease has been reported, but, to date, only seven patients with pulmonary nodular-type LCDD have been reported in the literature [11][12][13][14][15]. These patients were mainly asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

Light chain deposition disease involving the airways: diagnosis by fibreoptic bronchoscopy

Colombat¹,

Gounant²,

Mal³

et al. 2007

Eur Respir J

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Light chain deposition disease (LCDD) infrequently affects the lungs and usually causes damage to the parenchyma, while bronchial involvement appears to be very rare. The present authors report the case of a 64-yr-old female with LCDD characterised by asymptomatic airway involvement.Ten months after excision of a poorly differentiated vaginal carcinoma, a routine chest computed tomography (CT) scan revealed two lung cysts, several bilateral nodules and diffuse bronchial thickening. Pulmonary function tests were normal. Fibreoptic bronchoscopy showed marked diffuse mucosal thickening with highly conspicuous vascular plexuses. Nonamyloidal deposits were found in the bronchial wall, but no definite diagnosis could be proposed.On follow-up, the patient was still asymptomatic and the CT scan and endoscopic appearance remained unchanged. The final diagnosis of k LCDD was established 18 months later by another series of bronchial biopsies with frozen samples. Interestingly, electron microscopy showed dense granular deposits associated with nonamyloidal fibrils. An increased number of lung cysts were observed 32 months after identification of bronchial abnormalities, confirming the progressive nature of the disease. No extrapulmonary deposits or immunoproliferative disorder were found.In conclusion, light chain deposition disease, which may remain latent for several years, can entirely involve large airways and may be diagnosed by bronchial biopsy.

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Plasmacytoma of the Lung Associated with Nodular Deposits of Immunoglobulin

Cited by 53 publications

References 0 publications

Tracheobronchial Amyloidosis- A Series of Two Cases

Tracheobronchial Amyloidosis- A Series of Two Cases

Primary pulmonary lymphoma

Light chain deposition disease involving the airways: diagnosis by fibreoptic bronchoscopy

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