Plasmacytoma of the mesentery

Thambi, Sugeeth M; Nair, Sreejith G.; Benson, Rony

doi:10.4103/jpgm.jpgm_296_18

Journal of Postgraduate Medicine

2018

DOI: 10.4103/jpgm.jpgm_296_18

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Plasmacytoma of the mesentery

Sugeeth M Thambi

Sreejith G. Nair

Rony Benson

Abstract: Extramedullary plasmacytoma represents 3%–5% of all plasma cell neoplasms. Plasmacytomas of the mesentery are extremely rare. We report the case of a 56-year-old man who presented with an abdominal mass and was diagnosed to have plasmacytoma of the mesentery. A literature review was also conducted on publications pertaining to solitary mesenteric plasmacytomas. These patients present late by which time the abdominal mass has reached a significant size. Radiation as a modality for local control has a limited ro… Show more

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Cited by 3 publications

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Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity

Tam,

Xu,

et al. 2024

Journal of Experimental Medicine

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The peritoneal cavity (PerC) is an important site for immune responses to infection and cancer metastasis. Yet few ligand–receptor axes are known to preferentially govern immune cell accumulation in this compartment. GPR34 is a lysophosphatidylserine (lysoPS)-responsive receptor that frequently harbors gain-of-function mutations in mucosa-associated B cell lymphoma. Here, we set out to test the impact of a GPR34 knock-in (KI) allele in the B-lineage. We report that GPR34 KI promotes the PerC accumulation of plasma cells (PC) and memory B cells (MemB). These KI cells migrate robustly to lysoPS ex vivo, and the KI allele synergizes with a Bcl2 transgene to promote MemB but not PC accumulation. Gene expression and labeling studies reveal that GPR34 KI enhances PerC MemB proliferation. Both KI PC and MemB are specifically enriched at the omentum, a visceral adipose tissue containing fibroblasts that express the lysoPS-generating PLA1A enzyme. Adoptive transfer and chimera experiments revealed that KI PC and MemB maintenance in the PerC is dependent on stromal PLA1A. These findings provide in vivo evidence that PLA1A produces lysoPS that can regulate GPR34-mediated immune cell accumulation at the omentum.

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Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity

Tam,

Xu,

et al. 2024

Journal of Experimental Medicine

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Extraosseous Plasmacytomas: A Radiologist’s Perspective—A Narrative Review of the Literature

Stefanidis,

Yusuf,

Mulita

et al. 2024

Diagnostics

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Extraosseous plasmacytomas (EPs) are rare neoplasms originating from plasma cells, often associated with multiple myeloma. EPs are classified into three subtypes: extramedullary myeloma, solitary extramedullary plasmacytoma (SEP), and multiple solitary plasmacytomas. They can manifest in various anatomical sites, including the lung, mediastinum, breast, liver, pancreas, stomach, mesentery, kidney, small and large bowel, testis, and soft tissue. Despite their rarity, EPs present a diagnostic challenge due to their non-specific imaging appearances, which can mimic other neoplastic and inflammatory conditions. This review aims to describe the radiographic features of EPs in the chest, abdomen, and pelvis based on a thorough analysis of the existing literature. While imaging plays a crucial role in the detection and characterization of EPs, histological confirmation is necessary to differentiate them from other neoplastic entities. The review underscores the importance of considering EPs in the differential diagnosis, particularly in patients with a history of multiple myeloma. Understanding the imaging characteristics of EPs is essential for accurate diagnosis and appropriate management. Early imaging is crucial in these patients to exclude the possibility of EP, as timely diagnosis can significantly impact patient outcomes.

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A Huge Mass in the Liver: Plasmacytoma

Cinli¹,

Yokuş²,

Goze³

et al. 2022

Tjh

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Plasmacytoma of the mesentery

Cited by 3 publications

References 8 publications

Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity

Phosphatidylserine phospholipase A1 enables GPR34-dependent immune cell accumulation in the peritoneal cavity

Extraosseous Plasmacytomas: A Radiologist’s Perspective—A Narrative Review of the Literature

A Huge Mass in the Liver: Plasmacytoma

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