Plasmacytoma rectum extending to para-rectal region

Gohil, Mehul; Bhavsar, Devang C; Suryanarayana, U; Jetly, Dhaval

doi:10.4103/0973-1482.140799

Cited by 9 publications

(9 citation statements)

References 3 publications

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“…6 Intraluminal disease can also present with symptoms mimicking other common gastrointestinal malignancies, such as microcytic anaemia, melaena, 7 haematochezia, 8 intussusception, 9 localised perforation 10 or tenesmus. 11 Table 1 details described presentations of intra-abdominal extramedullary plasmacytoma in the literature.…”

Section: Narrative Review Presentationmentioning

confidence: 99%

Gastrointestinal manifestations of extramedullary plasmacytoma: a narrative review and illustrative case reports

Glasbey

Arshad

Almond

et al. 2018

annals

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Introduction Solitary extramedullary plasmacytoma are rare, solid-mass tumours which appear immunophenotypically similar to multiple myeloma. The diagnosis and management of gastrointestinal plasmacytoma is complex and requires multidisciplinary input. This study presents a narrative review of intra-abdominal extramedullary plasmacytoma, illustrated with two case studies. Methods The PubMed database was searched without date restrictions for reports of intra-abdominal extramedullary plasmacytoma to synthesise a narrative review. Electronic records were reviewed at a high-volume, quaternary soft-tissue sarcoma centre to identify patients with histopathologically confirmed extramedullary plasmacytoma affecting the gastrointestinal tract. Results Gastrointestinal extramedullary plasmacytomas can present with mass effect or organ-specific dysfunction. Techniques for tissue diagnosis of extramedullary plasmacytoma vary dependent on location, with a formal diagnosis often being made from a resected specimen. Management can include surgery, radiotherapy, systemic chemotherapy or a combination. No high-quality evidence base exists to guide treatment. Two case studies of operated gastrointestinal extramedullary plasmacytoma are presented at different phases of disease progression, with a resultant impact on survival. Conclusion Intra-abdominal extramedullary plasmacytoma is a rare and heterogeneous condition that lacks consensus guidelines for diagnosis and management. Collaboration between international specialist centres will create better quality evidence for treatment of this cohort.

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Section: Narrative Review Presentationmentioning

confidence: 99%

Gastrointestinal manifestations of extramedullary plasmacytoma: a narrative review and illustrative case reports

Glasbey

Arshad

Almond

et al. 2018

annals

View full text Add to dashboard Cite

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“…For example, most scholars suggest that for lesions which are circumscribed and have a sufficiently large cut edge or a wide scope and a big tumor load, radiotherapy is difficult to achieve by a radical cure dose, and operation or added postoperative radiotherapy are reasonable choices for treatment. [17] Because the patient in this case was a young woman, and the tumor was located in the retroperitonea with a diameter > 10 cm, no affected regional lymph node was found during the surgery. As the radiation resistance of the tumor-adjacent organs was poor, the patient preferred surgical treatment that would reduce the tumor load while obtaining a clear pathological result.…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal extramedullary plasmacytoma

Wang

Li²,

Zhang³

et al. 2018

Medicine

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Rationale:The incidence of extramedullary plasmacytoma (EMP) accounts for 3% to 4% of all cases of generalized plasmacytoma. The most common pathogenic sites are the head and the neck. It is noteworthy that the pathogenic site in this case is extraperitoneal, which is uncommon in clinical practice. In this case report, we aim to discuss the clinical features and diagnosis as well as the treatment methods of EMP.Patient concerns:A 30-year-old female was admitted to our hospital due to a palpable right upper abdominal mass without symptoms of abdominal pain, diarrhea, constipation, fever, or oliguria.Diagnosis and interventions:Enhanced CT scan showed a right retroperitoneal mass, which we considered to be isolated fibroma. Multiple myeloma (MM) was excluded through whole-body diffusion weighted imaging (DWI) and bone marrow biopsy. The patient underwent retroperitoneal tumor resection, and the postoperative pathology revealed plasmacytoma. Thereafter, she received only postoperative radiotherapy.Outcomes:During the radiotherapy, the patient's condition and appetite were acceptable with I° gastrointestinal reaction. The CT examination of the chest and upper abdomen performed 4, 8, and 12 months after the radiotherapy still showed postoperative and postradiotherapy changes after retroperitoneal plasmacytoma resection without obvious abnormal signs. No recurrence and metastasis were detected after a one-year follow-up.Lessons:Retroperitoneal extramedullary plasmacytoma (EMP) is a rare condition that is frequently a diagnostic challenge, mainly due to its unusual location and nonspecific symptoms, especially in the early stages. The diagnosis of EMP is made through a combination of imaging and pathological examination. Presently, the combinations of radiotherapy and surgery or radiotherapy are the primary treatments, usually leading to an acceptable local control rate. The application of chemotherapy, however, should be carefully considered.

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“…The most common site is small intestine followed by stomach. [ 7 , 8 ] The incidence in colon is very rare, [ 9 , 10 ] especially in ileoceccal region is significantly low. Gabriel et al showed an extramedullaryileocecalplasmacytoma with a large ileocecal perforation.…”

Section: Discussionmentioning

confidence: 99%

Extramedullary plasmacytoma occuring in ileocecum

et al. 2017

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Rationale:Gastrointestinal solitary extramedullary plasmacytoma (EMP) is rare, just occupies about 5% of all EMPs. The most common site is small intestine followed by stomach. The colorectal incidence is much rare.Patient concerns:A 63-year-old female had an episodic pain around the umbilicus for about one week. The hyperemia and edema in the ileocecal mucosa were found in colonoscopy, and the endoscopy could not cross the ileocecal valve. The pathology specimens showed a high index suspicion of plasmacytoma.Diagnoses:The patient was diagnosed with extramedullary plasmacytoma.Interventions:A right hemicolectomy surgery was performed to treat the disease.Outcomes:Post surgery pathologic report showed low grade malignant mucosa associated marginal zone B cell lymphoma.Lessons:We report a case of an extramedullary plasmacytoma in ileocecum with abdominal pain and a review of extramedullary plasmacytoma.

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Plasmacytoma rectum extending to para-rectal region

Cited by 9 publications

References 3 publications

Gastrointestinal manifestations of extramedullary plasmacytoma: a narrative review and illustrative case reports

Gastrointestinal manifestations of extramedullary plasmacytoma: a narrative review and illustrative case reports

Retroperitoneal extramedullary plasmacytoma

Extramedullary plasmacytoma occuring in ileocecum

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