Plasmapheresis in renal transplant patients: a single-center experience

Basri, N; Shaikh, Ibraheem S; Shaheen, F

doi:10.1016/j.transproceed.2003.09.029

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…As a result for the first time, antibody levels can be followed prospectively during treatment. The treatment of antibody‐mediated rejection is largely based on case series and poorly controlled randomized trials that typically included multiple simultaneous treatments including apheresis . Nevertheless, apheresis appears to be an important modality in the treatment of antibody‐mediated rejection.…”

Section: Apheresis For the Treatment Of Antibody‐mediated Kidney Rejementioning

confidence: 99%

Therapeutic apheresis in renal transplantation; current practices

Keith

2014

J of Clinical Apheresis

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Apheresis is an important treatment modality for the removal of pathologic antibodies and circulating proteins in kidney transplantation. The use of apheresis has been shown to be a necessary preconditioning component in ABO incompatible kidney transplant. Removal of pathologic anti-A and anti-B antibodies has been accomplished with a variety of apheresis modalities including plasma exchange, fractional plasma exchange, and immunoabsorption techniques. Using these modalities in conjunction with potent modern immunosuppression, ABO incompatible kidney transplants have achieved graft and patient survivals similar to that seen in ABO compatible transplants. Apheresis has also been an important modality in the removal of anti-human leukocyte antigen (HLA) antibodies both for the purposes of desensitization and treatment of antibody mediated rejection of the kidney. Although good randomized controlled trials are lacking in the treatment of acute antibody mediated rejection, most treatment regimens include the use of apheresis as an essential component for reduction of anti-HLA antibody titers. Similarly, a variety of desensitization protocols have been developed to allow highly sensitized kidney transplant candidates to be successfully transplanted in the presence of donor-specific HLA antibodies. Most of these protocols involve apheresis to improve the removal of pathologic antibodies. Finally, aphereis has been used with mixed success for the treatment of recurrent focal segmental glomerulosclerosis. Evidence indicates that in some cases a circulating factor exists which apheresis can remove and ameliorate the nephrotic proteinuria.

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Section: Apheresis For the Treatment Of Antibody‐mediated Kidney Rejementioning

confidence: 99%

Therapeutic apheresis in renal transplantation; current practices

Keith

2014

J of Clinical Apheresis

View full text Add to dashboard Cite

show abstract

Plasmapheresis in renal transplant patients: a single-center experience

Cited by 1 publication

References 13 publications

Therapeutic apheresis in renal transplantation; current practices

Therapeutic apheresis in renal transplantation; current practices

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