Plasmapheresis in the management of psoriasis

Schuster, Roman; Lenzhofer, R; Raff, Manfred

doi:10.1007/bf00509092

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…However, the results of hemodialysis are conflicting [12,13]. Skin lesions responded favorably in 6 out of 9 patients treated with plasma exchange, but the effect was transient [14]. A similar beneficial but transient effect was found in most of the 9 patients subjected to plasma exchange and/or leukapheresis, including 2 patients with arthritis [15].…”

Section: Introductionmentioning

confidence: 83%

Effects of Cascade Apheresis in Patients with Psoriasis and Psoriatic Arthropathy

Jørstad

Bergh²,

Iversen³

et al. 1998

Blood Purif

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Eight patients with psoriasis, all with skin scales and 7 with disabling psoriatic arthritis, were subjected to cascade apheresis starting with three treatments per week for 2 weeks, followed by one treatment a week, comprising ten treatments in all. Six out of 7 patients (86%) with arthropathy and 3 out of 8 patients (38%) with scales experienced a beneficial effect. There was a large drop in the levels of circulating immune complexes (CIC) due to the treatment, and the removal of CIC was followed by reduced inflammatory activity in skin lesions and joints as evaluated by pain, morning stiffness, grip strength, plaque score, and PASI index. However, there was no correlation between the level of CIC, disease activity, or treatment response. From the present results it is concluded that CIC may play a more significant role regarding psoriatic arthropathy than in skin manifestations, and apheresis may be beneficial in patients not responding to conventional therapy.

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