2016
DOI: 10.1159/000444059
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Plasmatic Ganglioside Profile and Age-Related Macular Degeneration: A Case-Control Study

Abstract: Purpose: Gangliosides are glycosphingolipids that are particularly abundant in the nervous system, including the retina. However, their precise role in this tissue and its pathologies remain poorly understood. The objective of the present study was to characterize the ganglioside profile of human plasma and to determine whether it is affected in age-related macular degeneration (AMD). Methods: Eighty-three subjects were included: control subjects (n = 25), atrophic AMD patients (n = 27) and exudative AMD patie… Show more

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Cited by 4 publications
(3 citation statements)
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“…Removal of PL, prior to analysis, is thus essential for an accurate analysis of GG by HILIC-ESI-MS. The phase partition method followed by C18 cartridges used in our previous works [8,[10][11][12], is known to be a powerful tool to remove PL from lipid extracts. However, this multi-step method is very time consuming.…”
Section: Resultsmentioning
confidence: 99%
“…Removal of PL, prior to analysis, is thus essential for an accurate analysis of GG by HILIC-ESI-MS. The phase partition method followed by C18 cartridges used in our previous works [8,[10][11][12], is known to be a powerful tool to remove PL from lipid extracts. However, this multi-step method is very time consuming.…”
Section: Resultsmentioning
confidence: 99%
“…Dossarps et al quantitatively analyzed plasma GLS produced during macular degeneration using QqQ-MS in combination with MRM mode and the results revealed GLS changes during macular degeneration. 12 Ranasinghe employed the UPLC-Q-Orbitrap MS method with the MRM mode to accurately quantify six Fuc-GM 1 subclasses in rats with lung cancer and found that the Fuc-GM 1 level increased during cancer development. 13 Alzheimer's disease (AD) is the leading cause of dementia, affecting approximately fifty million people worldwide.…”
Section: Introductionmentioning
confidence: 99%
“…There is limited clinical research that evaluated the role of sphingolipids in the pathogenesis of AMD. A recent case-control study examined plasmatic gangliosides, that are synthesized by sequential glycosylation of ceramides, but failed to find significant differences in the levels of these glycosphingolipids between controls, GA and CNV patients [ 43 ]. In the present study, serum levels of ceramides and SM from late stage AMD patients and healthy age-matched controls were quantified by electrospray ionization tandem mass spectrometry (ESI-MS/MS).…”
Section: Introductionmentioning
confidence: 99%