2019
DOI: 10.4183/aeb.2019.16
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Plasmatic Levels of Neuropeptides, Including Oxytocin, in Children with Autism Spectrum Disorder, Correlate with the Disorder Severity

Abstract: Context. Oxytocin has been investigated as a potential medication for psychiatric disorders. Objective and design. This study prospectively investigates correlations between oxytocin and other neuropeptides plasma levels in patients with autism spectrum disorders (ASD) according to severity and treatment, as compared to controls. Subjects and methods. Thirty-one children (6 neurotypical as control) participated in this study. The patients were classified into mildly and severely-affected, according to Autism D… Show more

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Cited by 17 publications
(13 citation statements)
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“…Another study underlined a strong correlation between plasma levels of oxytocin and orexin A in the ASD groups investigated. This finding supported the contribution of oxytocinergic mechanisms in ASD [154]. However, there are few studies in this field and the results are still contradictory.…”
Section: Orexin Systemsupporting
confidence: 68%
“…Another study underlined a strong correlation between plasma levels of oxytocin and orexin A in the ASD groups investigated. This finding supported the contribution of oxytocinergic mechanisms in ASD [154]. However, there are few studies in this field and the results are still contradictory.…”
Section: Orexin Systemsupporting
confidence: 68%
“…Since the promoter regions for genes of both oxytocin 137 and vasopressin systems 138 are susceptible to epigenetic modification 138 , these genes may be altered by global DNA methylation measured after developmental BDE-47 exposure 46, 139 . Our findings may have translational value since altered OXT and AVP mechanisms in humans have been implicated in ASD 140,141,142,143 .…”
Section: Discussionmentioning
confidence: 76%
“…Our findings may have translational value since altered OXT and AVP mechanisms in humans have been implicated in ASD 140,141,142,143 .…”
Section: Perinatal De-71 Alters Avp and Otergic Neuromolecular Phenotypes In Brain Regions That Coordinate Complex Social Behaviorsmentioning
confidence: 81%
“…Since the promoter regions for genes of both oxytocin (Mamrut et al 2013 ) and vasopressin systems (Auger et al 2011 ) are susceptible to epigenetic modification (Auger et al 2011 ), these genes may be altered by global DNA methylation that is possible after developmental BDE-47 exposure (Woods et al 2012 ); (Poston and Saha 2019 ). Our findings may have translational value since altered OXT and AVP mechanisms in humans have been implicated in ASD and other psychiatric and neurological disorders (Zhang et al 2016 ); (Kobylinska et al 2019 ); (Hendaus et al 2019 ); (Oztan et al 2018 ).…”
Section: Discussionmentioning
confidence: 81%