Plasmid DNA cleavage by oxo-bridged vanadium(III) dimers without added co-oxidants or reductants

Abstract

Plasmid DNA is cleaved by dimeric 0x0-bridged vanadium(II1) complexes without exogenous oxidants or reductants.

Chloro[N,N′-dimethyl-N,N′-bis(2-pyridylmethyl)ethane-1,2-diamine]oxovanadium(IV) perchlorate

“…This conformation is comparable to that observed for other mononuclear transition-element complexes of the same ligand [see, for example, Raffard et al (2002) and Li et al (1991)]. The distorted octahedral coordination of the V atom is completed by an oxo and a chloro ligand, forming a geometry typical of that for similar V IV complexes [see, for example, Brand et al (1990), Otieno et al (1996) and Tolis et al (2001)]. The two VÐN(pyridine) distances are 2.120 (2) and 2.141 (2) A Ê , whereas the VÐN(amine) distances are longer and show considerable difference attributable to the trans in¯uence of the vanadyl O atom; the VÐN(amine) distances cis and trans to O1 are 2.1755 (19) and 2.329 (2) A Ê , respectively.…”

Synthesis, structure, DNA binding and DNA cleavage activity of oxovanadium(IV) N-salicylidene-S-methyldithiocarbazate complexes of phenanthroline bases

“…The lack of chemical nuclease activity is presumably due to the presence of high and low redox potential values for the {V V O} 3+ /{V IV O} 2+ and {V IV O} 2+ /{V III O} + couples. In contrast, oxo-bridged divanadium(III) complexes having 1,10-phenanthroline are known to show chemical nuclease activity cleaving plasmid DNA by the formation of hydroxyl or superoxide radicals [66]. Similarly, bleomycin-vanadyl(IV) and [VO(phen) (H 2 O) 2 ] 2+ complexes oxidatively cleave DNA in the presence of hydrogen peroxide [41,42].…”

Synthesis and Structures of Vanadium(III) and -(IV) Complexes with a Tripodal Quadridentate Ligand Containing Alcoholic and Pyridyl or Imidazolyl Functionality

“…The sixth coordination position is occupied by a chloro ligand. The bond length between the vanadium(III) center (V1) and the bridging oxo atom (O1) in complex 1 compares well with the corresponding bond lengths of other hexacoordinate oxo-bridged dinuclear vanadium(III) complexes [7,23,24,26] [10], reflecting a lower coordination number (six vs. seven).…”

“…The X-ray crystal structure revealed that complex 1 is a single oxo-bridged dinuclear complex with a crystallographically enforced center of symmetry on the bridging oxo atom. Although such a strictly linear V(III)-O-V(III) bridging mode has been observed in [V III 2 O(NH 3 ) 10 ]I 4 [23], the V(III)-O-V(III) moiety usually takes a slightly bent configuration because of some weak inter-and/or intramolecular interactions such as stacking [24,25] and hydrogen bond formation [8,9]. In a mononuclear unit, the vanadium(III) center adopts a distorted octahedral geometry.…”