Plasmid Profile of Multi-drug Resistant Phenotypes of Pseudomonas aeruginosa Isolated among Patients with Indwelling Catheter in Northeastern Nigeria

Umoru, Askira M.; Farouk, U.A.; Ibrahim, Muhammad Bello; Tom, Isyaka M.; Ali, Haruna B.; Adamu, A. K.

doi:10.9734/ijpr/2018/v1i21270

Cited by 1 publication

(1 citation statement)

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“…has been implicated in diverse nosocomial infection likes nosocomial pneumonia, urinary tract infection, surgical site infection, severe burns and infections of patients undergoing either chemotherapy for neoplastic disease or those on antibiotic therapy [31] [32]. The unique feature of P. aeruginosa is the resistance to a variety of antibiotics, primarily attributed to low permeability of the cell wall, production of inducible cephalosporinase, active efflux and poor affinity for the target (DNA gyrase) [33].…”

Section: Discussionmentioning

confidence: 99%

Infection of Wounds by Potential Bacterial Pathogens and Their Resistogram

Tom¹,

Ibrahim²,

Umoru³

et al. 2019

OALib

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The major innate barrier to the establishment of infections in internal tissues is the skin, the disruption of which leads to wound formation. Such wounds can be contaminated by bacterial pathogens thereby hampering the healing process and its management becomes resource demanding. Here, we assess the diversity of potential bacterial pathogens in the infection of different types of wounds among hospitalized patients. Three hundred and twenty wound swab samples were collected and processed via microscopy, and cultured on Blood, MacConkey and Chocolate Agar. Isolates were further confirmed using biochemical tests and Kirby Bauer disc diffusion test was used to determine their antimicrobial susceptibility pattern. 87.5% of samples collected yielded bacterial growth comprising of single bacterial isolates (52.17%) and polymicrobial/mixed growth (47.82%). Staphylococcus aureus (32.61%) was the most prevalent bacterial specie identified. Gram-negative bacteria (62.33%) were the most pervasive group, chief among which were E. coli (23.64%) and Pseudomonas aeruginosa (17.13%). Rate of infection was highest among Wound sepsis and Burns wound where Enterobacter spp. and Streptococcus spp. were the most prevalent respectively. Differences in wound type in relation to rate of infection with Gram-negative bacteria was statistically significant (f = 5.9592; df = 29; p-value = 0.001645; p < 0.01; Mean ± SD = 7.633 ± 6.3706). Resistivity profile of isolates has shown that the most significant resistance rate was against Amoxicillin and Ampicillin, among Gram-positive and Gram-negative bacteria identified respectively. This suggests that wounds can be infected by potential bacterial pathogens which can exacerbate the progression of the wound and complicate the healing process.

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Section: Discussionmentioning

confidence: 99%