Plasmin and thrombin inhibitors in essentially untreated patients with coronary artery spasm

Handa, Koichi; Kimoto, Kazuyuki; Kawaguchi, Hiroshi; Mori, Tsukasa; Matsunaga, Akira; Sasaki, Jun; Arakawa, Kikuo

doi:10.1016/0167-5273(93)90058-o

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Yasu et al, 12 Kienast et al, 13 and Munkvad et al 14 found that aspirin improves the hypercoaguable state and increases AT III levels in unstable angina. 1214 Handa et al 15 found significantly lower AT III levels when coronary artery spasm is present. Uno et al, 16 Suzuki et al, 17 and Abe et al 18 found that if a patient has had an MI, thrombin-antithrombin (TAT) complexes are elevated even after the MI has stabilized.…”

Section: Review Of the Literaturementioning

confidence: 97%

Is Low AT III a Significant Risk Factor for Coronary Artery Disease? Anecdotal Observations

Dickerson¹

1997

Semin Thromb Hemost

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I report on my 6-year experience identifying the correlation of low antithrombin III (AT III) levels with coronary artery disease in a rural Missouri family practice setting. I measured plasma AT III levels in 78 patients who were at risk for coronary artery disease. I also tracked lipid profiles, HBA1C, blood pressure, body mass index, hostility, and nicotine use. I measured AT III levels using Baxter Diagnostic AG Dade antithrombin III chromogenic coagulation assays of antithrombin III (normal range, 88% to 126%) at the Boone County Hospital Laboratory, Columbia, Missouri. I analyzed the patient records and looked for the worst recording of each of the above risk factors, selecting the highest blood pressure, total cholesterol, LDL cholesterol, triglycerides, HBA1C, weight, and age. I selected the lowest AT III level, which often occurred when the patient was stressed. When the worst risk factors were picked over a long period of time, low AT III correlated with an arbitrary coronary artery disease scale 24% of the time. This negative correlation (r = -.49) was higher than any other risk factor in these selected patients.

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