Plasminogen activator inhibitor-1 4G/5G polymorphism in infertile women with and without endometriosis

Abstract

The data suggest that, in Brazilian women, the PAI-1 4G/5G polymorphism may be associated with a risk of endometriosis-associated infertility.

Genetic Variants in Fibrinolytic System-Related Genes in Infertile Women With and Without Endometriosis

“…Similar findings were found by Gentilini et al (2009). Our group (Gonçalves-Filho et al, 2011) previously observed a significant difference between genotypic frequencies of the PAI-1 4G/5G polymorphism in infertile women with endometriosis compared with controls, especially in women with advanced disease. Regarding the infertile women without endometriosis, no significant differences from controls were detected.…”

“…Our group previously evaluated PAI-1 (4G/5G) genotypes in a group of infertile women with or without endometriosis. The genotype frequencies were statistically different between infertile women with endometriosis and controls ( p = 0.003), suggesting that PAI-1 4G/5G polymorphism may be associated with a risk of endometriosis-associated infertility (Gonçalves-Filho et al, 2011).…”

Interplay between Misplaced Müllerian-Derived Stem Cells and Peritoneal Immune Dysregulation in the Pathogenesis of Endometriosis

“…Among the huge number of interleukin polymorphism, a case-control study based on Korean population [65] reported that the C627T polymorphism of the IL-2R beta gene may not be associated with the risk of endometriosis. Another study provided by Gonçalves-Filho et al [66] Proposed that plasminogen activator inhibitor-1 4G/5G polymorphism may be associated with a risk of endometriosis-associated infertility. About the endometriosis-associated infertility André et al [67] reported that FoxP3 polymorphisms can be associated with risk of idiopathic infertility (rs2280883 and rs2232368) and endometriosis (rs3761549), and this is congruent with other reports (see before) about the importance of FoxP3 + CD4 + Tregs in the pathogenesis of the disease.…”

Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress

“…Finally, polymorphisms in the plasminogen activator inhibitor PAI-1 gene may also modulate fibrinolysis. In a study evaluating PAI-1 genotypes in a group of women with and without endometriosis, 4G/4G and 4G/5G PAI-1 genotypes were particularly prevalent in infertile women with endometriosis compared to fertile women [69].…”