The tumor manifestations of leukemia, lymphoma, and multiple myeloma in body organs have been described for over a century.While the natural histories of each type of solid tumor is well known, that of hematologic tumors in the same organ site have not been elucidated. Knowledge of hematologic tumors has been limited to their description in individual case reports of tumors in any organ.The natural history of hematologic tumors in individual sites and their metastatic patterns has not been tracked, except for tumors at a few sites. Similar patterns of growth and spread between leukemic and solid tumors in breast, ovary, and GI sites were revealed. [1][2][3] Extensive studies of leukemic breast tumors and specimen analyses found histologic and genetic similarities of leukemic to solid breast cancers. 4 The present literature review was undertaken to ascertain