Plasmocytome solitaire pulmonaire traité par radiothérapie: à propos d’un cas et revue de la littérature

Elmorabit, B.; Derhem, N.; Khouchani, Mouna

doi:10.11604/pamj.2019.34.92.20089

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…However, over recent years, the development of "precision radiotherapy" is defned as stereotactic body radiation therapy, has indicated its precise, low, and noninvasive side efects, which furnishes more possibilities of treatment for lung cancer by radiotherapy [3]. While several methods for comprehensive radiotherapybased treatment are involved in NSCLC, it tolerates ionizing radiation with progressive radiotherapy, indicating that most such patients had essentially serious efects [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Radiosensitivity in Non-Small-Cell Lung Cancer by MMP10 through the DNA Damage Repair Pathway

Cao

Wang

et al. 2023

Journal of Oncology

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NSCLC (non-small-cell lung cancer) is an aggressive form of lung cancer and accompanies high morbidity and mortality. This study investigated the function and associated mechanism of MMP10 during radiotherapy of NSCLC. MMP10 expression in patients and their overall survival rate were assessed through GEPIA. Protein expression was tested by western blotting. Radioresistance was detected in vitro by apoptosis and clonogenic assay. The extent of DNA damage and repair was revealed by the comet test and γH2AX foci test. High MMP10 levels in specimens of lung adenocarcinoma were related to poor patient outcomes. Clonogenic and apoptosis assays revealed that MMP10 knockdown in A549 cells initiated radiosensitization. Furthermore, MMP10 siRNA increased damage to the DNA in NSCLC cells, while MMP10 was observed to participate in DNA damage repair post-ionizing radiation. Thus, after irradiation, MMP10 plays an essential role in NSCLC through the repair pathway of DNA damage; regulating MMP10 for NSCLC radiosensitivity might have potential treatment implications in radiotherapy of NSCLC.

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Section: Introductionmentioning

confidence: 99%

Radiosensitivity in Non-Small-Cell Lung Cancer by MMP10 through the DNA Damage Repair Pathway

Cao

Wang

et al. 2023

Journal of Oncology

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A Case Report on Solitary Extramedullary Plasmacytoma of the Pleura

Mandal¹,

Jha²,

Bethala³

et al. 2022

Cureus

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Solitary plasmacytoma is an extremely rare form of plasma cell malignancy that presents as a single mass of monoclonal plasma cells located either intraosseous or extramedullary (extraosseous). Extramedullary plasmacytoma can affect any part of the body, but the most common sites of origin are the head and neck region. The involvement of pleura is very rare. Here, we are enlightening this rare presentation and making readers aware of the clinical presentation and management of this rare malignancy.

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Plasmocytome solitaire pulmonaire traité par radiothérapie: à propos d’un cas et revue de la littérature

Cited by 2 publications

References 19 publications

Radiosensitivity in Non-Small-Cell Lung Cancer by MMP10 through the DNA Damage Repair Pathway

Radiosensitivity in Non-Small-Cell Lung Cancer by MMP10 through the DNA Damage Repair Pathway

A Case Report on Solitary Extramedullary Plasmacytoma of the Pleura

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