2020
DOI: 10.3390/molecules25245949
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Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments

Abstract: Recent progress in reducing malaria cases and ensuing deaths is threatened by factors like mutations that induce resistance to artemisinin derivatives. Multiple drugs are currently in clinical trials for malaria treatment, including some with novel mechanisms of action. One of these, MMV390048, is a plasmodial kinase inhibitor. This review lists the recently developed molecules which target plasmodial kinases. A systematic review of the literature was performed using CAPLUS and MEDLINE databases from 2005 to 2… Show more

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Cited by 19 publications
(8 citation statements)
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“…Putative parasite protein kinase PBANKA_1016200 is a membrane protein involved in protein phosphorylation and ATP binding. Even though it is dispensable in both P. berghei and P. falciparum , in general, protein kinases have been an attractive subset of proteins to be used as antimalarial targets (reviewed in reference 89 ).…”
Section: Resultsmentioning
confidence: 99%
“…Putative parasite protein kinase PBANKA_1016200 is a membrane protein involved in protein phosphorylation and ATP binding. Even though it is dispensable in both P. berghei and P. falciparum , in general, protein kinases have been an attractive subset of proteins to be used as antimalarial targets (reviewed in reference 89 ).…”
Section: Resultsmentioning
confidence: 99%
“…The inhibition of serine/arginine-rich proteins, result in protein-phosphorylating cyclin-dependent kinase also inhibiting the erythrocytic-stage replication ( Kern et al, 2014 ). Mustière et al (2020) have reviewed a number of inhibitors against plasmodial kinases.…”
Section: Invasion and Egress Of Merozoites And Inhibitionmentioning
confidence: 99%
“…Furthermore, CDPKs are critical for various physiological processes in the malaria parasite lifecycle [57] . Consequently, CDPKs have been considered as potentially good drug targets for the discovery of novel antimalarial agents (see reviews [18] , [77] , [83] . High throughput screening has led to the identification of different Pf CDPK1 targeting inhibitory scaffolds including 2,3,9-trisubstituted purines [59] , indolizines [68] and imidazopyridazines [68] , [47] , [4] , [22] , [23] , [66] ( Table 3 ).…”
Section: Targeting Cdpks Of Malaria Parasite For Drug Development and Functional Characterizationmentioning
confidence: 99%