2019
DOI: 10.1038/s41598-018-38175-1
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Plasmodium falciparum histidine-rich protein (PfHRP2 and 3) diversity in Western and Coastal Kenya

Abstract: Plasmodium falciparum histidine-rich proteins 2 (PfHRP2) based RDTs are advocated in falciparum malaria-endemic regions, particularly when quality microscopy is not available. However, diversity and any deletion in the pfhrp2 and pfhrp3 genes can affect the performance of PfHRP2-based RDTs. A total of 400 samples collected from uncomplicated malaria cases from Kenya were investigated for the amino acid repeat profiles in exon 2 of pfhrp2 and pfhrp3 genes. In addition, PfHRP2 levels were measured in 96 individu… Show more

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Cited by 35 publications
(96 citation statements)
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“…All other repeat types were found in over 90% of the isolates. These findings are consistent with previous reports from other countries [18,20,28,[30][31][32].…”
Section: Discussionsupporting
confidence: 94%
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“…All other repeat types were found in over 90% of the isolates. These findings are consistent with previous reports from other countries [18,20,28,[30][31][32].…”
Section: Discussionsupporting
confidence: 94%
“…However, some repeat organizations were shared between isolates. Most of our sequences started with type 1 and all terminated with type 12 as is consistent with previous studies [18][19][20]28]. Additionally, a semiconserved PfHRP2 repeat type motif (types 2, 3, 5, 7, 8, 2 and 7) and partial repeat motif (types 7, 8, 2 and 7) were found in about half and a quarter of our isolates, respectively.…”
Section: Discussionsupporting
confidence: 91%
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