Plasmodium Falciparum Infection in the Pregnant Patient

Alecrim, Wilson Duarte; Espinosa, Flor Ernestina Martinez; Alecrim, M. G

doi:10.1016/s0891-5520(05)70219-1

Cited by 23 publications

(7 citation statements)

References 53 publications

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“…During pregnancy, the acquired antimalarial immunity of a woman residing in a malaria-endemic area decreases. 3 Several studies over the past two decades, especially in Nigeria, have shown that the prevalence of malaria in neonates appears to be increasing with values as high as 25%. 4,5 The true burden of congenital malaria, however, might be underestimated because of the nonspecific clinical picture and the absence or the delayed presentation of symptoms.…”

Section: Introductionmentioning

confidence: 99%

Congenital Malaria in Newborns Presented at Tororo General Hospital in Uganda: A Cross-Sectional Study

Hangi

Achan

Saruti³

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Despite recent large-scale investments, malaria remains a major public health concern. Few studies have examined congenital malaria, defined as the presence of malaria parasitemia within the first 7 days of life, in endemic areas. This study aimed to determine the prevalence, to describe the clinical presentation, and to examine factors associated with congenital malaria in newborns aged up to 7 days attending Tororo General Hospital in Uganda. A total of 261 mother/baby pairs were recruited in this cross-sectional study. Giemsa-stained thick blood smears for malaria parasites and rapid malaria diagnostic tests were performed on capillary blood samples from all newborns and mothers, as well as on placental and cord samples from newborns delivered in the hospital. The prevalence of congenital malaria in the newborns was 16/261 (6.1%). No single clinical feature was associated with congenital malaria. However, there were associations between congenital malaria and maternal parasitemia (P < 0.001), gravidity of one (P = 0.03), maternal age < 19 years (P = 0.01), cord blood parasitemia (P = 0.01), and placental malaria (P = 0.02). In conclusion, congenital malaria is not rare in Uganda and there are no obvious clinical features associated with it in the newborn. Based on these findings, we recommend strengthening malaria prevention during pregnancy to reduce the occurrence of congenital malaria in newborns.

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Section: Introductionmentioning

confidence: 99%

Congenital Malaria in Newborns Presented at Tororo General Hospital in Uganda: A Cross-Sectional Study

Hangi

Achan

Saruti³

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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“…Pregnant women with malaria infection are particularly prone to developing severe anemia, acute kidney injury, disseminated intravascular coagulation, shock, seizures, and hypoglycemia, whereas obstetric complications include miscarriage, intrauterine death, preterm labor, and low birth weight. 12 This case illustrates recrudescence of P. falciparum after a prolonged period of apparent latency during pregnancy. Walters in 1960 and Mahmood in 1966 reported cases of imported P. falciparum in the United Kingdom in Nigerian women after prolonged quiescence, specifically at 17 and 19 months.…”

Section: Discussionmentioning

confidence: 95%

Recrudescence of Plasmodium falciparum in a Primigravida After Nearly 3 Years of Latency

Hammadi

Mitchell

Abraham

et al. 2017

The American Society of Tropical Medicine and Hygiene

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We present a case of a primigravid woman who presented with nearly 3 years after she last visited a malaria-endemic region. We review the literature to identify case reports of recrudescent malaria during pregnancy, including those with prolonged latency. Reports of recrudescence of during pregnancy are limited. infection can persist for years. Recrudescence can occur with waning of immunity following departure from endemic areas. Pregnancy, particularly the primigravid state, is a risk factor for severe infection.

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“…A fisiopatologia da anemia é multifatorial -resultante da hemólise de eritrócitos infectados e não infectados, destruição direta do parasito, que ocorre pela seqüestração dos eritrócitos infectados na placenta. Pode ainda resultar de resposta imunológica específica e não específica e da supressão da hematopoiese (OMS, 1995;MENÉNDEZ, 1995;ALECRIM et al 2000;ADAM et al, 2005;UNEKE, 2007a;UNEK, 2008).…”

Section: Consequencias Da Malária Na Gestaçãounclassified

Malária em gestantes no município de Cruzeiro do Sul pertencente à região amazônica brasileira

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Plasmodium Falciparum Infection in the Pregnant Patient

Cited by 23 publications

References 53 publications

Congenital Malaria in Newborns Presented at Tororo General Hospital in Uganda: A Cross-Sectional Study

Congenital Malaria in Newborns Presented at Tororo General Hospital in Uganda: A Cross-Sectional Study

Recrudescence of Plasmodium falciparum in a Primigravida After Nearly 3 Years of Latency

Malária em gestantes no município de Cruzeiro do Sul pertencente à região amazônica brasileira

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