Plasmodium gallinaceum: Vaccination in chickens

McGhee, Robert B.; Singh, Swapnil; Weathersby, A. B.

doi:10.1016/0014-4894(77)90027-3

Cited by 11 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11,[23][24][25][26][27][28][29][30][31] Such studies usually induced high mortality, unless birds were treated with antimicrobials 23,31 or the organisms were attenuated. 27,28 In young chickens, mortality rates may be decreased by reducing the size of the infectious challenge 29 or by using older (and consequently larger) birds. 30 Chickens that recover from bloodtransmitted malaria become refractory to disease when reinoculated with infected blood.…”

Section: Discussionmentioning

confidence: 99%

“…30 Chickens that recover from bloodtransmitted malaria become refractory to disease when reinoculated with infected blood. [23][24][25]27,28,30,31 Regarding mosquito-transmitted P. gallinaceum, prior experiments predominantly used hatchlings or chicks even younger than those in the current study. 13 Thus, both the route of inoculation and the age of the birds appear to affect the ability of chickens to recover from P. gallinaceum infection, as mortality was high in the above studies but was nil in the current experiment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Plasmodium Gallinaceum: Clinical Progression, Recovery, and Resistance to Disease in Chickens Infected via Mosquito Bite

Paulman

McAllister

2005

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Historically, in vivo experiments of Plasmodium gallinaceum in chickens have caused high mortality. Perhaps because of this high mortality, it remains to be demonstrated whether recovered birds will resist a second episode of illness when re-exposed to infected mosquitoes. In the current study, groups of 10 chicks were infected with P. gallinaceum via mosquito bite. Parasitemia and anemia were followed by recovery in all birds, although they had persisting, low levels of parasitized erythrocytes (0.007 +/- 0.019%). Twenty-three days after the initial exposure, 10 recovered chicks were rechallenged with P. gallinaceum via mosquito bite; none of them developed clinical or hematological evidence of malaria, in contrast to matched control birds, which all became diseased (P < 0.001). Unlike previous studies, the current experiment had no mortality in chickens infected with P. gallinaceum by mosquito bite. Recovered birds resisted disease from re-exposure to the same organism. The duration and nature of immunity or premunition remain to be determined.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Plasmodium Gallinaceum: Clinical Progression, Recovery, and Resistance to Disease in Chickens Infected via Mosquito Bite

Paulman

McAllister

2005

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…In 1945, Freund et al (120) induced strong protection against P. lophurae in ducks by immunization with formalinkilled erythrocytic stages in adjuvant. Formalin-killed merozoites in adjuvant were shown to induce stage-specific protection against P. fallax in turkeys (147), and McGhee et al (204) obtained complete protection in chickens with P. gallinaceum erythrocytic stages. In mice, partial protection was achieved by vaccination with inactivated (cryopreserved and homogenized) P. chabaudi merozoites in complete Freund's adjuvant (149).…”

Section: Empirical Observations Of Asexual Erythrocytic-stage Immunitymentioning

confidence: 99%

Acquired Immunity to Malaria

2009

View full text Add to dashboard Cite

SUMMARY Naturally acquired immunity to falciparum malaria protects millions of people routinely exposed to Plasmodium falciparum infection from severe disease and death. There is no clear concept about how this protection works. There is no general agreement about the rate of onset of acquired immunity or what constitutes the key determinants of protection; much less is there a consensus regarding the mechanism(s) of protection. This review summarizes what is understood about naturally acquired and experimentally induced immunity against malaria with the help of evolving insights provided by biotechnology and places these insights in the context of historical, clinical, and epidemiological observations. We advocate that naturally acquired immunity should be appreciated as being virtually 100% effective against severe disease and death among heavily exposed adults. Even the immunity that occurs in exposed infants may exceed 90% effectiveness. The induction of an adult-like immune status among high-risk infants in sub-Saharan Africa would greatly diminish disease and death caused by P. falciparum. The mechanism of naturally acquired immunity that occurs among adults living in areas of hyper- to holoendemicity should be understood with a view toward duplicating such protection in infants and young children in areas of endemicity.

show abstract

“…The list of discoveries and achievements using avian malarial models includes new antimalarial drugs (Davey, 1951; Coatney et al , 1953), the first cultivation methods of tissue and erythrocytic stages in vitro (Trager, 1950; Ball & Chao, 1961), and the first steps in the development of an antimalarial vaccine (McGhee, Singh & Weathersby, 1977). Ball (1964) described a technique for the cultivation of the sporogonic cycle of Plasmodium relictum : it was possible to grow P. relictum in vitro from the gametocyte stage to infective Sporozoites.…”

Section: Diptera Vectors Transmitting Avian Haemosporidian Parasitesmentioning

confidence: 99%

Diptera vectors of avian Haemosporidian parasites: untangling parasite life cycles and their taxonomy

2012

View full text Add to dashboard Cite

Haemosporida is a large group of vector-borne intracellular parasites that infect amphibians, reptiles, birds, and mammals. This group includes the different malaria parasites (Plasmodium spp.) that infect humans around the world. Our knowledge on the full life cycle of these parasites is most complete for those parasites that infect humans and, to some extent, birds. However, our current knowledge on haemosporidian life cycles is characterized by a paucity of information concerning the vector species responsible for their transmission among vertebrates. Moreover, our taxonomic and systematic knowledge of haemosporidians is far from complete, in particular because of insufficient sampling in wild vertebrates and in tropical regions. Detailed experimental studies to identify avian haemosporidian vectors are uncommon, with only a few published during the last 25 years. As such, little knowledge has accumulated on haemosporidian life cycles during the last three decades, hindering progress in ecology, evolution, and systematic studies of these avian parasites. Nonetheless, recently developed molecular tools have facilitated advances in haemosporidian research. DNA can now be extracted from vectors' blood meals and the vertebrate host identified; if the blood meal is infected by haemosporidians, the parasite's genetic lineage can also be identified. While this molecular tool should help to identify putative vector species, detailed experimental studies on vector competence are still needed. Furthermore, molecular tools have helped to refine our knowledge on Haemosporida taxonomy and systematics. Herein we review studies conducted on Diptera vectors transmitting avian haemosporidians from the late 1800s to the present. We also review work on Haemosporida taxonomy and systematics since the first application of molecular techniques and provide recommendations and suggest future research directions. Because human encroachment on natural environments brings human populations into contact with novel parasite sources, we stress that the best way to avoid emergent and reemergent diseases is through a program encompassing ecological restoration, environmental education, and enhanced understanding of the value of ecosystem services.

show abstract

Plasmodium gallinaceum: Vaccination in chickens

Cited by 11 publications

References 18 publications

Plasmodium Gallinaceum: Clinical Progression, Recovery, and Resistance to Disease in Chickens Infected via Mosquito Bite

Plasmodium Gallinaceum: Clinical Progression, Recovery, and Resistance to Disease in Chickens Infected via Mosquito Bite

Acquired Immunity to Malaria

Diptera vectors of avian Haemosporidian parasites: untangling parasite life cycles and their taxonomy

Contact Info

Product

Resources

About