2016
DOI: 10.1186/s12936-016-1524-y
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Plasmodium vivax msp-3α polymorphisms: analysis in the Indian subcontinent

Abstract: BackgroundPlasmodium vivax is the most widely distributed human malaria parasite and accounts for approximately the same number of malaria cases as Plasmodium falciparum in India. Compared with P. falciparum, P. vivax is difficult to eradicate because of its tendency to cause relapses, which impacts treatment and control strategies. The genetic diversity of these parasites, particularly of the merozoite surface protein-3 alpha (msp-3α) gene, can be used to help develop a potential vaccine. The present study ai… Show more

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Cited by 15 publications
(12 citation statements)
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“…In fact, other studies analyzing isolates from different regions of a country displayed more polymorphism in this gene than in the collection of Omani parasites [7, 13, 37]. Motifs I and II were the same for all the Omani parasites.…”
Section: Discussionmentioning
confidence: 85%
See 1 more Smart Citation
“…In fact, other studies analyzing isolates from different regions of a country displayed more polymorphism in this gene than in the collection of Omani parasites [7, 13, 37]. Motifs I and II were the same for all the Omani parasites.…”
Section: Discussionmentioning
confidence: 85%
“…The nearly identical Pvmsp3 alpha genotype of the Omani parasites demonstrates a common origin of the cases. In fact, other studies analyzing isolates from different regions of a country displayed more polymorphism in this gene than in the collection of Omani parasites [ 7 , 13 , 37 ]. Motifs I and II were the same for all the Omani parasites.…”
Section: Discussionmentioning
confidence: 99%
“…[18] Despite the higher prevalence of P. vivax in India, very few studies were carried out on the various polymorphic markers of P. vivax , such as PvMSP3 β , PvCSP , PvMSP1 . [119] However, reports from other countries such as Pakistan,[20] Thailand,[21] China and Myanmar,[22] and Korea[23] have observed higher genetic diversity among the P. vivax isolates. Based on the previous data on PvMSP3β , the present study was found to be the second study in India till date.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, in silico analysis of MSP-1 and MSP-3α in P. vivax isolates from other endemic areas, including India, Myanmar, and Venezuela [ 18 , 19 , 30 , 31 ] suggested that the PCR-RFLP methods are also applicable for subtyping of global P. vivax isolates. However, attention should be required to apply the methods to global P. vivax isolates considering that the genetic diversities of MSP-1 and MSP-3α of P. vivax circulating in tropical and subtropical endemic areas are much higher than those in Korean isolates [ 17 19 , 24 , 26 , 30 , 31 ]. Considering the rapid genetic dissemination observed in Korean P. vivax population, we also could not exclude possibility of the appearance of new genotype of P. vivax probably due to genetic recombination and/or introduction of new genotypes from other endemic countries, which may affect population structure of the Korean P. vivax .…”
Section: Discussionmentioning
confidence: 99%