Plasmon-Emitter Hybrid Nanostructures of Gold Nanorod-Quantum Dots with Regulated Energy Transfer as a Universal Nano-Sensor for One-step Biomarker Detection

Li, Xuemeng; Wang, Yingshuting; Fu, Quanying; Wang, Yangyang; Ma, Dongxu; Zhou, Bin; Zhou, Jianhua

doi:10.3390/nano10030444

Cited by 9 publications

(7 citation statements)

References 61 publications

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“…This system can therefore be used as a sensor for the detection of the cellular Leucine-rich α-2-glycoprotein-1 mRNA. Some fluorescence-involved sensing schemes rely on the relationship between the fluorescence intensity of emitting species and their distance from the surface of Au NRs . One example is the detection of the E. coli O157:H7 eaeA gene.…”

Section: Applicationsmentioning

confidence: 99%

“…Some fluorescence-involved sensing schemes rely on the relationship between the fluorescence intensity of emitting species and their distance from the surface of Au NRs. 1040 One example is the detection of the E. coli O157:H7 eaeA gene. ssDNA can undergo conformational changes in the presence of the E. coli O157:H7 eaeA gene, leading to changes in their distance from the Au NR surface and thereby the fluorescence intensity.…”

Section: Applicationsmentioning

confidence: 99%

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Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

et al. 2021

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Gold nanorods (NRs), pseudo-one-dimensional rod-shaped nanoparticles (NPs), have become one of the burgeoning materials in the recent years due to their anisotropic shape and adjustable plasmonic properties. With the continuous improvement in synthetic methods, a variety of materials have been attached around Au NRs to achieve unexpected or improved plasmonic properties and explore state-of-the-art technologies. In this review, we comprehensively summarize the latest progress on Au NRs, the most versatile anisotropic plasmonic NPs. We present a representative overview of the advances in the synthetic strategies and outline an extensive catalogue of Au-NR-based heterostructures with tailored architectures and special functionalities. The bottom-up assembly of Au NRs into preprogrammed metastructures is then discussed, as well as the design principles. We also provide a systematic elucidation of the different plasmonic properties associated with the Au-NR-based structures, followed by a discussion of the promising applications of Au NRs in various fields. We finally discuss the future research directions and challenges of Au NRs.

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Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

et al. 2021

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“…The limit of detection (LOD) of the Au@Ag NRs-PDMS composite for H 2 S was calculated as three times the standard deviation of the y-intercept over the slope of the calibration line. [46][47][48] Therefore, the LOD is expressed as: LOD = 3S y /k, where S y is the standard deviation of the y-intercept and k is the slope of the calibration line. S y was be obtained from Origin 9.…”

Section: Methodsmentioning

confidence: 99%

Au@Ag Nanorods‐PDMS Wearable Mouthguard as a Visualized Detection Platform for Screening Dental Caries and Periodontal Diseases

Chen

et al. 2022

Adv Healthcare Materials

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The development of easy-to-use, low-cost, and visualized detection platforms for screening human dental caries and periodontal diseases is in urgent demand. In this work, a Au@Ag nanorods-poly(dimethylsiloxane) (Au@Ag NRs-PDMS) wearable mouthguard, which can visualize the tooth lesion sites through the color change of it at the corresponding locations, is presented. The Au@Ag NRs-PDMS composite exhibits a distinct color response to hydrogen sulfide (H 2 S) gas generated by bacterial decay at the lesion sites. Moreover, the Au@Ag NRs-PDMS mouthguard is demonstrated to own desired mechanical properties, excellent chemical stability, as well as good biocompatibility, and can accurately locate the lesion sites in human oral cavity. These findings suggest that the mouthguard has the potential to be utilized on a large scale to help people self-monitor their oral health in daily life, and treat oral diseases locally.

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“…The overlapping integrals as well as the transfer efficiency are found to be highest in case of Au-BSA-CdSe FRET pair due to increased spectral overlap of the plasmonic band with the luminescence band of QDs. The coupling behavior of the QDs and the Au NPs (or Au-Protein) could be changed not only by the overlapping of the absorption spectra of Au NPs (or Au-Protein) and emission spectra of the QDs, it is also affected by the distance between absorber (Au, Au-BSA, Au-Lysozyme) and the emitter (CdSe QDs) [67].…”

Section: Molecular Vibrations In Aumentioning

confidence: 99%

“…The calculated d 0 values for Au NPs, Au-BSA complex and Au-Lysozyme complexes are calculated to be 73.5, 90, 58 Å; respectively. Here, it is important to mention that for an ideal FRET pair, the typical Forster distance is in the range of 20-100 Å [67]. Hence, FRET can be likely to occur in all the systems.…”

Section: Molecular Vibrations In Aumentioning

confidence: 99%

Novel gold nanoparticle-protein-semiconductor quantum dot hybrid system: synthesis, characterization and application in cancer cell imaging

Sarma¹,

Das²,

Saikia³

et al. 2021

Nanosystems: Phys. Chem. Math.

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Formation of a hybrid system by metallic nanoparticle, protein (or peptide), and a semiconductor QD can be a new and alternate material which may be used for biological applications including cancer cell detection and treatment. Herein, we report on the colloidal synthesis of metal-protein-QD hybrid system considering Au NPs, CdSe QDs, BSA and Lysozyme protein. We demonstrate the structural, optical and vibrational properties of Au-CdSe, Au-BSA-CdSe and Au-Lysozyme-CdSe hybrid systems following their use as cancer cell markers. The study of photoluminescence spectra reveals the predominance fluorescence resonance energy transfer (FRET) between CdSe QDs and Au NPs, Au-BSA and Au-Lysozyme complex. The energy transfer efficiency between QDs donor and the Au NPs, Au-BSA, Au-Lysozyme acceptors are estimated to be 46%, 94% and 64%; respectively. Fluorescence imaging results represent high biocompatibility and fluorescent behavior of the QDs and its hybrid system in the MDA-MB-231 breast cancer cells. The calculation of corrected total counts of fluorescence (CTCF) predicts the higher uptake of CdSe QDs as compared to the Au-QDs, Au-BSA-QDs, Au-Lysozyme-QDs by the cells. The significantly varied zeta potential values of the hybrid systems influence the cellular uptake processes. The fabrication of biocompatible (water soluble, biologically stable, having bioconjugation capability, low cytotoxic to the normal cells, fluorescent in biological environment) Au-CdSe, Au-protein-CdSe hybrid systems would open up an alternative strategy in nanobiotechnology, due to their special physical, optical as well as chemical properties.

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Plasmon-Emitter Hybrid Nanostructures of Gold Nanorod-Quantum Dots with Regulated Energy Transfer as a Universal Nano-Sensor for One-step Biomarker Detection

Cited by 9 publications

References 61 publications

Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

Au@Ag Nanorods‐PDMS Wearable Mouthguard as a Visualized Detection Platform for Screening Dental Caries and Periodontal Diseases

Novel gold nanoparticle-protein-semiconductor quantum dot hybrid system: synthesis, characterization and application in cancer cell imaging

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