Plasmon Resonant Silica-Coated Silver Nanoplates as Contrast Agents for Optical Coherence Tomography

Meleppat, Ratheesh Kumar; Prabhathan, Patinharekandy; Keey, Seah Leong; Murukeshan, Vadakke Matham

doi:10.1166/jbn.2016.2297

Cited by 13 publications

(3 citation statements)

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“…To improve the stability and biocompatibility of silver nanoplatelets, [27][28][29] microfluidicsenabled surface coating strategy was developed to synthesize hierarchical anisotropic silver core-silica shell nanostructures using the same short range two-loop spiral-shaped microreactor. The two inlet flows, one containing the as-synthesized tAg (5 mM) together with TEOS (90 mM) and the other ammonia (1 M), were pumped into the microreactor at a flow rate of 50 and 100 μL/min, respectively, at room temperature ( Figure 4A).…”

Section: Resultsmentioning

confidence: 99%

Ultrafast microfluidic synthesis of hierarchical triangular silver core-silica shell nanoplatelet toward enhanced cellular internalization

Hao

Nie

Xü

et al. 2019

Journal of Colloid and Interface Science

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Microfluidic reactors represent a new frontier in the rational design and controllable synthesis of functional micro-/nanomaterials. Herein, we develop a continuous and ultrafast flow synthesis method to obtain triangular silver (tAg) nanoplatelet using a short range two-loop spiral-shaped laminar flow microfluidic reactor, with one inlet flow containing AgNO 3 , trisodium citrate, and H 2 O 2 and the other NaBH 4. The effect of the reactant concentration and flow rate on the structural changes of tAg is examined. Through the same miniaturized microreactor, hierarchical core-shell Ag@SiO 2 can be produced with tunable silica shell thickness using one inlet flow containing the as-synthesized Ag nanoparticles together with tetraethyl orthosilicate and the other ammonia. The enhanced cellular internalization efficiency of triangular nanoplatelets by PANC-1 and MCF-7 cells is further confirmed in comparison with the spherical ones. These results not only bring new insights for engineering nanomaterials from microreactors but also facilitate the rational design of functional nanostructures for enhancing their biological performance.

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Section: Resultsmentioning

confidence: 99%

Ultrafast microfluidic synthesis of hierarchical triangular silver core-silica shell nanoplatelet toward enhanced cellular internalization

Hao

Nie

Xü

et al. 2019

Journal of Colloid and Interface Science

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“…Modern optical coherence tomography (OCT), laser confocal microscopy, and multiphoton microscopy have a spatial resolution of about 1–2 μm [ 23 , 24 , 25 ]. Multicolor two-photon excited autofluorescence microscopy, two-photon exited autofluorescence (TPAF) microscopy, and fluorescence lifetime imaging microscopy (FLIM) make it possible to visualize a single nanoobject in the case of its bright emission in a spectral range placed far from a wavelength of pumping femtosecond laser [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

A Criterion of Colorectal Cancer Diagnosis Using Exosome Fluorescence-Lifetime Imaging

et al. 2022

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This study was aimed to investigate the applicability of the exosome fluorescence-lifetime imaging microscopy (FLIM) for colorectal cancer (CRC) diagnosis. Differential ultra-centrifugation was used to extract exosomes from the blood plasma of 11 patients with colon polyps (CPs) and 13 patients with CRC at the T2-4, N0-3, and M0-1 stages. Analysis was performed using a two-photon FLIM device. In total, 165 and 195 FLIM images were recorded for the CP and CCR patient groups, respectively. Two classes of exosomes differentiated by autofluorescence average lifetime tm were discovered in the samples. The first class of exosomes with tm = (0.21 ± 0.06) ns was mostly found in samples from CRC patients. The second class with tm = (0.43 ± 0.19) ns was mostly found in samples from CP patients. The relative number of “CRC-associated” exosomes Nch in the FLIM dataset was shown to be very small for the CP patient group and large for the CRC patient group. This difference was statistically significant. Therefore, the suggested CRS diagnostics criterion can be as follows. If Nch > 0.5, the probability of CRC is high. If Nch < 0.3, the probability of CRC is low.

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“…Artificial bioparticles usually have a variety of morphological forms. Due to the development of miscellaneous numerical tools, including the discrete-dipole approximation (DDA) method, 8 , 9 the T-matrix method, 10 and the finite-difference time-domain method 11 – 14 , the optical and radiative properties have been widely investigated. Also, the particles’ nonsphericity, 15 , 16 inhomogeneity, 17 – 19 porosity, 20 surface roughness, 21 , 22 etc.…”

Section: Introductionmentioning

confidence: 99%

Optimized shape and structure of artificial bioparticles to enhance the optical extinction properties

Ding

et al. 2022

Opt. Eng.

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. A multilayer structure of microbial cells can result in multiple attenuations of electromagnetic waves, making the biological particles have a strong extinction ability. However, the influence of various morphologies on infrared band optical extinction performance of biomaterials is unclear. The combination of shape, dimension, and structure parameters is proposed to evaluate and enhance the optical extinction properties of artificial bioparticles. Combined with the preliminary work of our research group, four artificial biological particles were selected to simulate and calculate their extinction performance with different parameters theoretically based on the discrete-dipole approximation method. The results show the extinction properties of bioparticles with different shapes and dimensions in the 3.0 to 5.0 μm and 8.0 to 14.0 μm wavebands. It was found that the chain-shaped particles with more constituent spheres and a bending angle of 60 deg as well as the ellipsoid-shaped particles with an axis ratio of 1:2 exhibit better extinction properties in the above two bands. Among them, the regulation of extinction efficiency can reach ∼13.92 % and 18.16%.

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Plasmon Resonant Silica-Coated Silver Nanoplates as Contrast Agents for Optical Coherence Tomography

Cited by 13 publications

References 0 publications

Ultrafast microfluidic synthesis of hierarchical triangular silver core-silica shell nanoplatelet toward enhanced cellular internalization

Ultrafast microfluidic synthesis of hierarchical triangular silver core-silica shell nanoplatelet toward enhanced cellular internalization

A Criterion of Colorectal Cancer Diagnosis Using Exosome Fluorescence-Lifetime Imaging

Optimized shape and structure of artificial bioparticles to enhance the optical extinction properties

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