Plasmon-Tuned Silver Colloids for SERRS Analysis of Methemoglobin with Preserved Nativity

Kalaivani, Govindasamy; Sivanesan, Arumugam; Kannan, Ayyadurai; Narayanan, N.; Kamińska, Agnieszka; Sevvel, Ranganathan

doi:10.1021/la303136v

Cited by 19 publications

(23 citation statements)

References 47 publications

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“…This approach has good biocompatibility and can be used for label‐free protein detection. Researchers have also developed a SERS‐based analysis of methemoglobin (metHb) using functionalized AgNPs 112. Mercaptononanoic acid (MNA) is modified onto the AgNPs to preserve the native structure of the heme pocket, which is an important part of the protein.…”

Section: Candidate Nanomaterialsmentioning

confidence: 99%

Nanomaterials for Ultrasensitive Protein Detection

et al. 2013

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The advances of nanomaterials have provided exciting technologies and novel materials for protein detection, based on the unique properties associated with nanoscale phenomena such as plasmon resonance, catalysis and energy transfer. This article reviews a series of nanomaterials including nanoparticles, nanofibers, nanowires, and nanosheets, and evaluates their performances in the application for protein detection, focusing on approaches that realize ultrasensitive detection. Many of these nanomaterials were used to analyze clinically relevant protein biomarkers. Their detection in the picomolar, femtomolar or even zeptomolar regime has been realized, sometimes even with naked‐eye readout. We summarize the detection methods and results according to materials and targets, review the current challenges, and discuss the solution in the context of technological integration such as combining nanomaterials with microfluidics, and classical analytical technologies.

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Section: Candidate Nanomaterialsmentioning

confidence: 99%

Nanomaterials for Ultrasensitive Protein Detection

et al. 2013

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“…In recent years, surface-enhanced Raman spectroscopy (SERS) has become a very sensitive analytical technique for identifying traces of analytes ranging from small chemicals to macromolecules/microorganisms such as bacteria and viruses. [1][2][3][4][5][6] Nevertheless, the sensitivity of the SERS technique largely relies on the presence of a sensitive substrate, i.e., a strong enhancing surface for the incident and Raman photons by plasmon resonance. [7][8][9] SERS enhancement is a joint effect of the electromagnetic and chemical enhancement; the former is a predominant contributor to the observed enhancement, in particular on metallic surfaces.…”

Section: Introductionmentioning

confidence: 99%

A homogeneous surface-enhanced Raman scattering platform for ultra-trace detection of trinitrotoluene in the environment

et al. 2015

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A facile and sensitive surface-enhanced Raman scattering substrate was prepared by controlled potentiostatic deposition of closely packed single layer of gold nanostructures (AuNS) over flat gold (pAu) platform. The nanometer scale inter-particle distance between the particles resulted in high population of 'hot spot' which enormously enhanced the scattered Raman photons. A renewed methodology was followed to precisely quantify the SERS substrate enhancement factor (SSEF) and it was estimated as (2.2 ± 0.17) × 10 5 . The reproducibility of the SERS signal acquired by the developed substrate was tested by establishing the relative standard deviation (RSD) of 150 repeated measurements from various locations on the substrate surface.A low RDS of 4.37 confirmed the homogeneity of the developed substrate. The sensitivity of pAu/AuNS was proven by determining 100 fM 2,4,6-trinitrotoluene (TNT) comfortably. As a proof of concept on the potential of the new pAu/AuNS substrate in field analysis, TNT in soil and water matrices was selectively detected after forming a Meisenheimer complex with cysteamine.

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“…22 We recently employed the equation given by Hildebrandt et al 22 for the quantication of the SSEF for silver colloids. [22][23][24][25] The modied form of that equation is:…”

Section: Overview Of the Renewed Approachmentioning

confidence: 99%

“…In the present study, a similar electrochemical approach has been followed to quantify the real surface area of the GC/Au SERRS substrate. 24,25 Further, we used diamond polished GC surfaces in all our experiments since they have the very at surface with negligible surface roughness. Therefore, in the case of diamond polished GC, the geometric area and real surface area are almost similar.…”

Section: Overview Of the Renewed Approachmentioning

confidence: 99%

Towards improved precision in the quantification of surface-enhanced Raman scattering (SERS) enhancement factors: a renewed approach

Sivanesan

Adamkiewicz

Kalaivani

et al. 2015

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This paper demonstrates a renewed procedure for the quantification of surface-enhanced Raman scattering (SERS) enhancement factors with improved precision. The principle of this method relies on deducting the resonance Raman scattering (RRS) contribution from surface-enhanced resonance Raman scattering (SERRS) to end up with the surface enhancement (SERS) effect alone. We employed 1,8,15,22-tetraaminophthalocyanato-cobalt(II) (4α-Co(II)TAPc), a resonance Raman- and electrochemically redox-active chromophore, as a probe molecule for RRS and SERRS experiments. The number of 4α-Co(II)TAPc molecules contributing to RRS and SERRS phenomena on plasmon inactive glassy carbon (GC) and plasmon active GC/Au surfaces, respectively, has been precisely estimated by cyclic voltammetry experiments. Furthermore, the SERS substrate enhancement factor (SSEF) quantified by our approach is compared with the traditionally employed methods. We also demonstrate that the present approach of SSEF quantification can be applied for any kind of different SERS substrates by choosing an appropriate laser line and probe molecule.

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Plasmon-Tuned Silver Colloids for SERRS Analysis of Methemoglobin with Preserved Nativity

Cited by 19 publications

References 47 publications

Nanomaterials for Ultrasensitive Protein Detection

Nanomaterials for Ultrasensitive Protein Detection

A homogeneous surface-enhanced Raman scattering platform for ultra-trace detection of trinitrotoluene in the environment

Towards improved precision in the quantification of surface-enhanced Raman scattering (SERS) enhancement factors: a renewed approach

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