Plasmonic Biosensors for Medical Applications

Puiu, Mihaela; Bala, Camelia

doi:10.1016/b978-0-12-822548-6.00141-2

Cited by 1 publication

(2 citation statements)

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“…Surface plasmons (SPs) are generated because of the coupling of the incident oscillating electric field of the electromagnetic (EM) wave with the electrons at the metal/dielectric interface. When an SP couples with a photon, the resulting excitation is called surface plasmon polariton (SPP) [ 10 ]. The incident light, after total internal reflection (TIR) within a glass prism, generates an electric field on the interface’s opposite site.…”

Section: Spr Operating Principlementioning

confidence: 99%

“…Thus, the response of the SPR sensor medium is sensitive to changes in the refractive index of the medium near the surface, changes that may be caused by affinity pairing, chemical reaction, adsorption/desorption, temperature, and pH [ 12 ]. The SPR signal can be measured according to three main methodologies: angular, wavelength, and intensity (amplitude) [ 10 ]. In a typical angular scanning SPR experiment, monochromatic light is directed to the metal surface at several incidence angles.…”

Section: Spr Operating Principlementioning

confidence: 99%

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Strategies for Surface Design in Surface Plasmon Resonance (SPR) Sensing

2023

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Surface plasmon resonance (SPR) comprises several surface-sensitive techniques that enable the trace and ultra-trace detection of various analytes through affinity pairing. Although enabling label-free, sensitive detection and real-time monitoring, several issues remain to be addressed, such as poor stability, non-specific adsorption and the loss of operational activity of biomolecules. In this review, the progress over sensor modification, immobilization techniques and novel 2D nanomaterials, gold nanostructures and magnetic nanoparticles for signal amplification is discussed. The advantages and disadvantages of each design strategy will be provided together with some of the recent achievements.

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Section: Spr Operating Principlementioning

confidence: 99%

Section: Spr Operating Principlementioning

confidence: 99%