Plasmonic gel nanocomposites for detection of high energy electrons

Abstract

The development of a plasmonic gel nanocomposite to detect therapeutic levels of high energy electrons is demonstrated.

Versatile Detection and Monitoring of Ionizing Radiation Treatment Using Radiation-Responsive Gel Nanosensors

“…Our foundational work on the gel nanosensor technology is based on the radiation-induced conversion of gold ions to gold nanoparticles, which renders a change in the colorless translucent precursor nanosensor gel to pink/maroon color (Figure A). − This leads to a simple and robust colorimetric device for the rapid detection of ionizing radiation for applications in trauma care and radiotherapy. − The fabrication of gel nanosensors follows a simple combination of four components. In the gold salts used in this study, gold ions exist in their native trivalent state (Au III , AuCl 4 – ), which associates with a cationic surfactant (C x TAB; x = 14; a number of carbons in the surfactant).…”

“…Gel nanosensor devices can be fabricated in different form factors – 1D, 2D, or 3D and are amenable to detection using simple detection methods including visual/optical and photothermal detection, which together suggests a high potential for clinical translation. Additional distinct advantages of the technology include (1) ease of formulation and fabrication by using widely available precursor chemicals and inexpensive equipment, (2) “one-stop” dose-detection technology for most radiotherapy-based applications, including with other sources such as ionizing electrons and protons. , We envision that these features of the gel nanosensor platform technology will not require significant training/re-training of personnel, which will allow for the routine use of dosimeters while causing minimal disruption, if any, to the workflow in radiation planning and delivery. Although the current technology is promising and can have a significant clinical impact, a thorough evaluation of the biocompatibility of these nanosensors is necessary prior to eventual translation for human use.…”

“…Nanotechnology-enabled sensors provide new solutions for the detection of ionizing radiation with increased selectivity and sensitivity . We have pioneered the development of a colorimetric sensor wherein ionizing radiation facilitates the generation of gold nanoparticles from their colorless ionic precursor solutions in liquid or gel formulations. − Here, for the first time, we demonstrate the adoption of this colorimetric radiation-responsive gel nanosensor technology toward multiple clinically relevant applications, including brachytherapy, by using them for dose detection in three distinct form factors: linear (1D), area (2D), and volumetric (3D) morphologies. We also demonstrate the use of distinct quantitative readout methods, including visual/optical and photothermal detection, which further augments the versatility of gel nanosensors.…”

The fabrication of bifunctional supramolecular glycolipid-based nanocomposite gel: insights into electrocatalytic performance with effective selectivity towards gold

“…7 Combining the significance of MNP with the self-assembly of amphiphilic gelator molecules will definitely increase its worth. Researchers are focusing on developing such kinds of soft gel nanocomposites with improved properties and emerging applications in several areas such as tissue engineering, 8 therapeutic agent, 9 3D printing and stem cell growth, 10 sensors, 11,12 antibacterial agent, 13 and biomedical applications. 14 LMWG self-assembles to form 3D fibrillar network structures, which represent the functional architecture for several nanoscale materials.…”

Fluorescent Nanogel Sensors for X-ray Dosimetry

“…Hydrogels feature three-dimensional polymeric networks with a large amount of water, showing good tissue equivalence. Hydrogels have garnered much attention for a variety of sensors, biosensors, and X-ray dosimeters. ,− Ionizing radiation-induced polymerization hydrogel-based dosimeters are widely studied; however, polymerization continues up to 48 h after irradiation. Therefore, they cannot be utilized immediately after irradiation .…”