Plasmonic nano-dumbbells for enhanced photothermal and photodynamic synergistic damage of cancer cells

Yin, Jinchang; Wu, Haonan; Wang, Xiang; Liu, Tian; Yang, Renlong; Liu, Lizhi; Shao, Yuanzhi

doi:10.1063/5.0003769

Cited by 12 publications

(8 citation statements)

References 24 publications

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“…Drug delivery is also sometimes referred to as chemotherapy. When combined with PTT and PDT, it has been proven very useful in different scenarios (refs , , , , , , , , , , , , , and − ).…”

Section: Applicationsmentioning

confidence: 99%

Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

et al. 2021

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Gold nanorods (NRs), pseudo-one-dimensional rod-shaped nanoparticles (NPs), have become one of the burgeoning materials in the recent years due to their anisotropic shape and adjustable plasmonic properties. With the continuous improvement in synthetic methods, a variety of materials have been attached around Au NRs to achieve unexpected or improved plasmonic properties and explore state-of-the-art technologies. In this review, we comprehensively summarize the latest progress on Au NRs, the most versatile anisotropic plasmonic NPs. We present a representative overview of the advances in the synthetic strategies and outline an extensive catalogue of Au-NR-based heterostructures with tailored architectures and special functionalities. The bottom-up assembly of Au NRs into preprogrammed metastructures is then discussed, as well as the design principles. We also provide a systematic elucidation of the different plasmonic properties associated with the Au-NR-based structures, followed by a discussion of the promising applications of Au NRs in various fields. We finally discuss the future research directions and challenges of Au NRs.

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Section: Applicationsmentioning

confidence: 99%

Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

et al. 2021

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“…Pursuant to the SBM equation (Equation S1–3), the relaxation of inner water protons around the designed CDSNPs is improved by a long rotational motion correlation time τ R of CDSNPs. A proper nanostructure tailored specifically might be conducive to a significant improvement of the performance. ,,− In this work, because the free rotation of Gd 2 O 3 nanoparticles is restricted upon anchoring to SiO 2 in the unique nanostructure of designed CDSNPs, the rotation motion time τ R increases, giving rise to a high inner longitudinal relaxivity r 1 IS .…”

Section: Resultsmentioning

confidence: 95%

Silica Nanoparticles Decorated with Gadolinium Oxide Nanoparticles for Magnetic Resonance and Optical Imaging of Tumors

Yin

Wang

Zheng

et al. 2021

ACS Appl. Nano Mater.

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structured nanoprobe that incorporates water-soluble silica and water-interacted gadolinium oxide, endowed with excellent hydrophilicity and high magnetic resonance imaging (MRI) relaxivity. The nanoprobes are monodispersed and uniformed with a superior stability due to the formation of Gd−O−Si bonds. The nanoprobe possesses an MRI relaxivity of 39.08 mM −1 s −1 , 9.3 times that of clinical Gd chelates, gaining a significant MRI enhancement in vivo; the classical Solomon− Bloembergen−Morgan theory is applied to explicate the relaxation enhancement mechanism. Multicolor and enhanced emissions are tunable through adjusting Yb 3+ /Li + -doping concentrations in Gd 2 O 3 :Yb 3+ /Er 3+ /Li + . A theoretical model based on the rate equations of upconversion energy-transfer processes is established to address the nanoprobe's photoluminescence. Cross-linked with folate-PEG, the nanoprobe can be absorbed by nasopharyngeal, cervical, and breast carcinoma cells, rendering a vivid multicolor living cell imaging. The nanoprobe owns a negligible nanotoxicity according to in vitro cytotoxicity and in vivo immunotoxicity, histopathology, and hematology assays. This study demonstrates that folate-PEGylated SiO 2 @Gd 2 O 3 :5%Yb 3+ /2%Er 3+ /6%Li + core@dotted-shell nanoprobes designated for multimodal imaging can achieve simultaneously enhanced MR relaxivity, photoluminescence efficiency, tumor-targeting ability, and biocompatibility. Both designing of nanoprobe and addressing MR/photoluminescence enhancement mechanism facilitate the development of practical multimodal imaging nanoprobes for accurate diagnosis of early tumors.

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“…[27][28][29][30][31][32][33] Yin et al performed photodynamic therapy using end-coated AuNRs and utilized lower laser powers to induce high levels of cancer cell death, hypothesizing that the localization of the photoactive molecule towards the active tips of the AuNRs helped improve their efficacy. 32 Surprisingly, even though extensive reports of successful anisotropic synthesis exist, to our knowledge, there are limited investigations utilizing these particles in a sensing application. 33 In this work, AuNRs were coated with mesoporous silica either all over or specifically on the tips by a template directed hydrolysis-condensation reaction of tetraethyl orthosilicate (TEOS).…”

Section: Introductionmentioning

confidence: 99%

“…The concentration of the free surfactant template in the AuNR solution, silica precursor, and other factors such as pH and cosolvent used for the silica precursor, can be exploited to form spherical porous shells isolated just at the tips of the AuNRs while keeping the particles colloidally stable. [27][28][29][30][31][32][33] Yin et al performed photodynamic therapy using end-coated AuNRs and utilized lower laser powers to induce high levels of cancer cell death, hypothesizing that the localization of the photoactive molecule towards the active tips of the AuNRs helped improve their efficacy. 32 Surprisingly, even though extensive reports of successful anisotropic synthesis exist, to our knowledge, there are limited investigations utilizing these particles in a sensing application.…”

Section: Introductionmentioning

confidence: 99%