Plasmonic Nanoprobes for SERS-Based Theranostics Applications

Das, Anindita; Moirangthem, Rakesh S.

doi:10.1007/978-3-030-99491-4_7

Cited by 2 publications

(2 citation statements)

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“…To reduce fabrication costs without sacrificing quality, researchers have started using nanoimprint lithography to create multiple copies of nanopatterned Si master stamps on flexible polymer or rigid substrates with high structural reproducibility and low processing costs. ,− It has been reported that silver nanostructures with small interparticle gaps can have a strong SERS enhancement factor (EF) due to the interband transition in the UV region being well separated from its plasmon band, causing less plasmon damping. In contrast, gold has both interband transition and plasmon band in the same spectral region . However, compared to gold, silver has lesser biocompatibility and stability as it degrades through oxidation in the air over time. , Therefore, designing a hybrid composite flexible SERS substrate is needed to improve the lifetime of silver-based SERS devices’ lifetimes.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, gold has both interband transition and plasmon band in the same spectral region. 36 However, compared to gold, silver has lesser biocompatibility and stability as it degrades through oxidation in the air over time. 37,38 Therefore, designing a hybrid composite flexible SERS substrate is needed to improve the lifetime of silver-based SERS devices' lifetimes.…”

Section: Introductionmentioning

confidence: 99%

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Wearable Surface-Enhanced Raman Spectroscopy Sensor Using Inverted Bimetallic Nanopyramids for Biosensing and Sweat Monitoring

Das,

Pant,

Cao

et al. 2023

ACS Appl. Opt. Mater.

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Surface-enhanced Raman spectroscopy (SERS) has gained prominence as a pivotal tool in optical sensing technology with tremendous potential. Extensive efforts have been dedicated to improving the practical aspects of SERS, focusing on cost effectiveness, stability, reproducibility, flexibility, and robustness. Herein, we employ a multistep molding process that incorporates electron beam lithography, nanoimprinting lithography, and subsequent e-beam thin film deposition. We first fabricated a Ag/Au bimetallic inverted nanopyramid (i-NPyr) and upright nanopyramid (u-NPyr) on flexible plastic substrates. A meticulous comparison of their SERS detection capabilities revealed impressive enhancement factors of 3.88 × 10 6 and 7.86 × 10 5 , respectively. Subsequently, the i-NPyr structures were successfully exploited to achieve ultrasensitive detection of the hemoglobin biomolecule at concentrations as low as 1 nM. Furthermore, the stability and resilience of i-NPyr for SERS performance were thoroughly investigated through angled bending and delicate crumpling tests. In addition, computational simulations were employed to gain a comprehensive understanding of the electromagnetic confinement within the substrate. Finally, a proof-of-concept demonstration of the i-NPyr SERS sensor as a wearable device was achieved by attaching it to a volunteer's neck in running and walking activities, successfully detecting constituents such as urea and lactic acid excreted in sweat. Thus, by combining the lithographic technique with imprinting, we produced SERS substrates with a precise morphology and sharp asperities, offering scalability and cost effectiveness on a large-scale production level. This innovative approach holds the potential to solve the challenges in wearable sensing technology, facilitating in situ measurement of important analytes of biological processes.

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