Plasmonic Photothermal Fluorescence Modulation for Homogeneous Biosensing

Pellegrotti, Jesica Vanesa; Cortés, Emiliano; Bordenave, Martín Diego; Caldarola, Martín; Kreuzer, Mark P.; Sánchez, Alfredo Daniel; Ojea, Ignacio; Bragas, Andrea V.; Stefani, Fernando D.

doi:10.1021/acssensors.6b00512

Cited by 21 publications

(14 citation statements)

References 43 publications

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“…[90] However, there remains a critical need for new technologies to address current limitations of this technology, such as long procedural time, heavy [82] Copyright 2012, Wiley-VCH. [89] Copyright 2016, American Chemical Society. The steps in the photothermal time trace data show real-time single-molecule binding and unbinding events.…”

Section: Sensingmentioning

confidence: 99%

Section: Bio‐applications Of Plasmonic Photothermal Nanoparticlesmentioning

confidence: 99%

“…Fluorescence labeling and detection has been a powerful method in various biomedical applications due to many analytical advantages . Pellegrotti et al reported a novel method of fluorescence quenching with plasmonic photothermal effect used for bioassay (Figure c) . They demonstrated that the fluorescence emission of organic dyes can be significantly reduced near nanoparticles by light‐induced thermal energy, which is different from the well‐known fluorescence suppression by metallic nanoparticles in close proximity due to direct energy transfer of the dyes to particles.…”

Section: Bio‐applications Of Plasmonic Photothermal Nanoparticlesmentioning

confidence: 99%

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Plasmonic Photothermal Nanoparticles for Biomedical Applications

2019

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Recent advances of plasmonic nanoparticles include fascinating developments in the fields of energy, catalyst chemistry, optics, biotechnology, and medicine. The plasmonic photothermal properties of metallic nanoparticles are of enormous interest in biomedical fields because of their strong and tunable optical response and the capability to manipulate the photothermal effect by an external light source. To date, most biomedical applications using photothermal nanoparticles have focused on photothermal therapy; however, to fully realize the potential of these particles for clinical and other applications, the fundamental properties of photothermal nanoparticles need to be better understood and controlled, and the photothermal effect‐based diagnosis, treatment, and theranostics should be thoroughly explored. This Progress Report summarizes recent advances in the understanding and applications of plasmonic photothermal nanoparticles, particularly for sensing, imaging, therapy, and drug delivery, and discusses the future directions of these fields.

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Section: Sensingmentioning

confidence: 99%

Section: Bio‐applications Of Plasmonic Photothermal Nanoparticlesmentioning

confidence: 99%

Section: Bio‐applications Of Plasmonic Photothermal Nanoparticlesmentioning

confidence: 99%

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Plasmonic Photothermal Nanoparticles for Biomedical Applications

2019

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“…These nanostructures can significantly enhance the interactions between quantum emitters (e.g., quantum dots, defect centers in crystals, molecules) and their surrounding photonic environment, leading to giant luminescence enhancement, ultrafast emission in the picosecond range, strong coupling, surface‐enhanced Raman scattering (SERS), optical interconnections, and control of emission patterns . Because of these advantages, plasmonic nanostructures are broadly used in many applications, including near‐field microscopy, biosensors, photovoltaics, photodetection, and medicine . However, the typical plasmonic materials, gold and silver, have finite conductivities at optical frequencies, leading to inherent dissipation of the electromagnetic energy.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopy and Biosensing with Optically Resonant Dielectric Nanostructures

Krasnok

Caldarola

Bonod

et al. 2018

Advanced Optical Materials

137

123

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Resonant dielectric nanoparticles made of materials with large positive dielectric permittivity, such as Si, GaP, GaAs, have become a powerful platform for modern light science, enabling various fascinating applications in nanophotonics and quantum optics. In addition to light localization at the nanoscale, dielectric nanostructures provide electric and magnetic resonant responses throughout the visible and infrared spectrum, low dissipative losses and optical heating, low doping effect, and absence of quenching, which are interesting for spectroscopy and biosensing applications. This review presents state‐of‐the‐art applications of optically resonant high‐index dielectric nanostructures as a multifunctional platform for light–matter interactions. Nanoscale control of quantum emitters and applications for enhanced spectroscopy including fluorescence spectroscopy, surface‐enhanced Raman scattering, biosensing, and lab‐on‐a‐chip technology are surveyed. The theoretical background underlying these effects is described, realizations of specific resonant dielectric nanostructures and hybrid excitonic systems are overviewed, and an outlook of the challenges in this field, which remain open to future research, is provided.

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“…Highly‐confined heat can also vaporize the surrounding media of the NP, affect stability of emitters or molecules nearby, or even create strong repulsive forces between nano‐objects . In recent years several applications, such as photothermal cancer therapy, photothermal imaging, and photothermal biosensing, among many others, have been proposed in order to take advantage of this highly‐localized heat generated in metallic‐based plasmonic nanoantennas. Although heat‐dissipation strategies may help to mitigate temperature increase in metal plasmonic NPs, real‐world applications so far have been strongly limited due to these drawbacks…”

Section: Metal and Dielectric Nanoantennas: The Role Of Lossesmentioning

confidence: 99%

Efficiency and Bond Selectivity in Plasmon‐Induced Photochemistry

Cortés

2017

Advanced Optical Materials

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these components was mainly passive in nature. As such, plasmonic nanoantennas have been widely used to explore the surrounding chemical environments, to couple with nearby emitters, or to produce heat in nanoscale regions. [7][8][9][10] On the other hand, the ability and understanding of using light to trigger chemical reactions at bulk metal surfaces has been advancing consistently since decades before the advent of plasmonics chemistry. Photoexcited states at the bulk metal-molecule interface have been studied by a vast number of techniques; surface photochemistry is a much older field compared with plasmonic chemistry and, for many years, has been closely associated with other areas of research such as heterogeneous (photo)catalysis and femtosecond chemistry. [11][12][13][14] Recently, the possibility to actively induce photochemical reactions by using plasmonic metal nanoparticles opened new avenues for both the plasmonic chemistry and surface photochemistry communities. [15] It is not the intention of this Progress Report to cover areas recently reviewed nicely by other authors [16][17][18][19][20][21] but to offer a more fundamental point of view on hot-carriers in the broader context of surface photochemistry and plasmonic chemistry. As such, I will start by briefly describing the traditional uses of plasmonic nanoantennas, emphasizing the role of energy losses within metal nanoparticles, and the recent appearance of high-refractive index dielectric antennas as powerful tools for enhancing electric and magnetic fields with minimal losses. I will then move forward to introduce the basis of molecular reactivity in photochemical reactions on both bulk metal surfaces and metal plasmonic nanoparticles before highlighting the new possibilities of plasmon-driven photochemistry regarding bond selectivity, enhanced (quantum and chemical) efficiency, and spatial distribution of reactivity. Complementary approaches studying charge-transfer processes and electronic transitions at the metal nanoparticle-molecule interface are briefly touched upon. Finally, a roadmap of challenges and possible routes to be explored is provided. Metal and Dielectric Nanoantennas: the Role of LossesLocalized surface plasmon resonances (LSPRs) can be triggered after light impinges on a metal nanoparticle (NP). The incident Light-induced chemical reactions on bulk metal surfaces have been explored for more than 50 years. Light absorption at the metal surface plays a key role in inducing photochemical transformations of adsorbed molecules. Our current ability to control both the absorption cross-sections and the energy of absorbed light by metal plasmonic nanoparticles opens new pathways for the manipulation of photochemical reactions. Physical phenomena associated with the localized surface plasmon resonances, such as energetic surface states and intensified electric fields, force us to revisit our traditional understanding of photochemical reactions at metal surfaces. Long standing goals in the field -such as bond selectivity and increas...

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Plasmonic Photothermal Fluorescence Modulation for Homogeneous Biosensing

Cited by 21 publications

References 43 publications

Plasmonic Photothermal Nanoparticles for Biomedical Applications

Plasmonic Photothermal Nanoparticles for Biomedical Applications

Spectroscopy and Biosensing with Optically Resonant Dielectric Nanostructures

Efficiency and Bond Selectivity in Plasmon‐Induced Photochemistry

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