Plasmonic photothermal therapy: Approaches to advanced strategy

Bucharskaya, Alla B.; Maslyakova, Gаlina N.; Chekhonatskaya, M.L.; Terentyuk, Georgy S.; Navolokin, Nikita; Khlebtsov, Boris N.; Khlebtsov, Nikolai G.; Bashkatov, Alexey N.; Genina, Elina A.; Tuchin, Valery V.

doi:10.1002/lsm.23001

Cited by 29 publications

(15 citation statements)

References 36 publications

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“…Many preclinical studies work with a laser at 1 W cm −2 , and sometimes even up to 3 or 5 W cm −2 . However, to assure totally safe conditions for the surrounding healthy tissues, the lower power density of 0.3 W cm −2 is generally admitted [ 41 ]. With this setting, the maximum temperature increase that can be reached with PT is around ΔT = 25 °C, and is attained at lower concentrations for the magnetite nanoparticles compared to the maghemite ones, with a concentration-dependent heating profile very similar to the one obtained at 1 W cm −2 .…”

Section: Resultsmentioning

confidence: 99%

“…A high temperature elevation of 33 • C nm was observed in PT using magnetite NPs at a concentration of 6.6 mM in Fe, however, the nanoparticles were 200 nm aggregates formed by the assembly of 21 nm nanoparticles [26]. On the other hand, an elevation of 10 • C was observed using 13 nm iron oxide magnetic NPs at a dose of 10 mg/mL but using a laser power of 14 W/cm 2 largely exceeding the limits of safety [27,41].…”

Section: Discussionmentioning

confidence: 97%

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Iron Oxide Mediated Photothermal Therapy in the Second Biological Window: A Comparative Study between Magnetite/Maghemite Nanospheres and Nanoflowers

et al. 2020

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The photothermal use of iron oxide magnetic nanoparticles (NPs) is becoming more and more popular and documented. Herein, we compared the photothermal (PT) therapy potential versus magnetic hyperthermia (MHT) modality of magnetic nanospheres, largely used in the biomedical field and magnetic multicore nanoflowers known among the best nanoheaters. The NPs were imaged using transmission electron microscopy and their optical properties characterized by UV-Vis-NIR-I-II before oxidation (magnetite) and after oxidation to maghemite. The efficiency of all NPs in MHT and PT in the preferred second near-infrared (NIR-II) biological window was carried out in water and in cancer cells. We show that, in water, magnetite nanoflowers are the most efficient nanoheaters for both modalities. Moreover, PT appears much more efficient than MHT at low NP dose, whatever the NP. In the cellular environment, for PT, efficiency was totally conserved, with magnetite nanoflowers as the best performers compared to MHT, which was totally lost. Finally, cell uptake was significantly increased for the nanoflowers compared to the nanospheres. Finally, the antitumor therapy was investigated for all NPs at the same dose delivered to the cancer cells and at reasonable laser power density (0.3 W/cm2), which showed almost total cell death for magnetite nanoflowers.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Iron Oxide Mediated Photothermal Therapy in the Second Biological Window: A Comparative Study between Magnetite/Maghemite Nanospheres and Nanoflowers

et al. 2020

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“…In the literature, a number of studies describe the photo thermal effect generated by the light irradiation of gold nanoparticles in tumors. [25][26][27] Indeed, production of plasmonic resonances can be stimulated and used to increase the local temperature drastically to provide heating capabilities to the nanoparticles to kill the cancer cells, without damage to the healthy tissue. This effect was extensively studied and demonstrated in different ways.…”

Section: Discussionmentioning

confidence: 99%

<p>A novel theranostic gold nanorods- and Adriamycin-loaded micelle for EpCAM targeting, laser ablation, and photoacoustic imaging of cancer stem cells in hepatocellular carcinoma</p>

Locatelli¹,

Li²,

Monaco³

et al. 2019

IJN

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Introduction and purpose: Cancer stem cells (CSCs) present a higher capacity to evade being killed by cancer agents and developing chemoresistance, thus leading to failure of conventional anticancer therapeutics. Nanomaterials specifically designed for targeting and treating not only tumor cells, but also CSCs, may encompass therapeutic and diagnostic tools, thus successfully eradicating the tumor. Materials and methods: Polymeric micelles simultaneously loaded with gold nanorods (GNRs) and Adriamycin were prepared and used as a novel therapeutic and diagnostic weapon. Epithelial cell adhesion molecule (EpCAM) is an important CSC surface marker and has been exploited in this work as an active targeting agent. Photoacoustic imaging was applied for GNR individuation and tissue recognition. Results: The nanosystem was demonstrated to be able to elicit effective targeting of cancer cells and cause their killing, in particular under laser ablation. Moreover, ex vivo photoacoustic imaging is able to clearly identify tumor regions thanks to GNR's contrast. Conclusion: The nanosystem can be considered a powerful and promising theranostic weapon for hepatocellular carcinoma treatment.

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“…In our study [188], Doppler ultrasonography was conducted to describe transplanted tumors vascularity for optimal choice at the beginning of plasmonic photothermal therapy. AuNRs functionalized with thiolated polyethylene glycol (PEG) with an aspect ratio of 4.1 were used for multiple fractional intravenous administration in rats with transplanted cholangiocarcinoma PC-1.…”

Section: The Nanoparticle Application For Antitumor Therapymentioning

confidence: 99%

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Bucharskaya

Khlebtsov

et al. 2022

Materials

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Cancer remains one of the leading causes of death in the world. For a number of neoplasms, the efficiency of conventional chemo- and radiation therapies is insufficient because of drug resistance and marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively explored in tumor treatment. However, despite attractive promises, the current PPT status is limited by laboratory experiments, academic papers, and only a few preclinical studies. Unfortunately, most nanoformulations still share a similar fate: great laboratory promises and fair preclinical trials. This review discusses the current challenges and prospects of plasmonic nanomedicine based on PPT and photodynamic therapy (PDT). We start with consideration of the fundamental principles underlying plasmonic properties of AuNPs to tune their plasmon resonance for the desired NIR-I, NIR-2, and SWIR optical windows. The basic principles for simulation of optical cross-sections and plasmonic heating under CW and pulsed irradiation are discussed. Then, we consider the state-of-the-art methods for wet chemical synthesis of the most popular PPPT AuNPs such as silica/gold nanoshells, Au nanostars, nanorods, and nanocages. The photothermal efficiencies of these nanoparticles are compared, and their applications to current nanomedicine are shortly discussed. In a separate section, we discuss the fabrication of gold and other nanoparticles by the pulsed laser ablation in liquid method. The second part of the review is devoted to our recent experimental results on laser-activated interaction of AuNPs with tumor and healthy tissues and current achievements of other research groups in this application area. The unresolved issues of PPT are the significant accumulation of AuNPs in the organs of the mononuclear phagocyte system, causing potential toxic effects of nanoparticles, and the possibility of tumor recurrence due to the presence of survived tumor cells. The prospective ways of solving these problems are discussed, including developing combined antitumor therapy based on combined PPT and PDT. In the conclusion section, we summarize the most urgent needs of current PPT-based nanomedicine.

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Plasmonic photothermal therapy: Approaches to advanced strategy

Abstract: The repeatable IVIs promote greater of GNR accumulation within the tumor thus resulting in higher PPT efficacy. Accompanying ultrasonography can be useful for prognosis and monitoring of treatment. Lasers Surg. Med. © 2018 Wiley Periodicals, Inc.

Cited by 29 publications

References 36 publications

Iron Oxide Mediated Photothermal Therapy in the Second Biological Window: A Comparative Study between Magnetite/Maghemite Nanospheres and Nanoflowers

Iron Oxide Mediated Photothermal Therapy in the Second Biological Window: A Comparative Study between Magnetite/Maghemite Nanospheres and Nanoflowers

<p>A novel theranostic gold nanorods- and Adriamycin-loaded micelle for EpCAM targeting, laser ablation, and photoacoustic imaging of cancer stem cells in hepatocellular carcinoma</p>

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

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