Plastic changes in ipsi-contralateral differences of auditory cortex and inferior colliculus evoked potentials after injury to one ear in the adult guinea pig

Popelář, Jiří; Erre, Jean‐Paul; Aran, Jean‐Marie; Cazals, Yves

doi:10.1016/0378-5955(94)90212-7

Cited by 102 publications

(58 citation statements)

References 42 publications

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“…Evidence from animals with experimentally induced UD indicates that increased neural responsiveness to stimulation of the intact ear occurs over a wide time frame. Initial increases in excitatory responses of cortical and sub-cortical neurons have been demonstrated within minutes to hours post-UD (Popelar et al 1994;Mossop et al 2000), while further changes have been observed a number of months post-UD (McAlpine et al 1997). Therefore, the data from animal studies are consistent with a cascade of multiple processes driving plasticity.…”

Section: Introductionmentioning

confidence: 93%

“…Furthermore, this deafferentation is similar to experimentally induced deafness in animals (although the presence of the acoustic neuroma itself often leads to partial hearing loss in the affected ear prior to surgery). Based on the findings from animal studies, a predicted increase in responsiveness to stimulation of the intact ear should be reflected by a decrease in the ABR latency and an increase in ABR amplitude (Popelar et al 1994). However, the post-surgery ABR latencies reported by Vasama et al (2001) were not statistically different from the pre-surgery baseline measures or those of a binaurally hearing control group, while amplitudes were not reported.…”

Section: Introductionmentioning

confidence: 98%

“…Experimentally induced UD in adult animals leads to increased neural responsiveness to stimulation of the intact ear (Popelar et al 1994;McAlpine et al 1997;Mossop et al 2000). The changes are greatest in the pathway ipsilateral to the intact ear, probably because this pathway normally receives the strongest input from the deafferented ear (Adams 1979;Coleman and Clerici 1987).…”

Section: Introductionmentioning

confidence: 99%

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Rapid Increase in Neural Conduction Time in the Adult Human Auditory Brainstem Following Sudden Unilateral Deafness

Maslin

Lloyd

Rutherford

et al. 2015

JARO

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Individuals with sudden unilateral deafness offer a unique opportunity to study plasticity of the binaural auditory system in adult humans. Stimulation of the intact ear results in increased activity in the auditory cortex. However, there are no reports of changes at sub-cortical levels in humans. Therefore, the aim of the present study was to investigate changes in subcortical activity immediately before and after the onset of surgically induced unilateral deafness in adult humans. Click-evoked auditory brainstem responses (ABRs) to stimulation of the healthy ear were recorded from ten adults during the course of translabyrinthine surgery for the removal of a unilateral acoustic neuroma. This surgical technique always results in abrupt deafferentation of the affected ear. The results revealed a rapid (within minutes) reduction in latency of wave V (mean pre=6.55 ms; mean post=6.15 ms; pG0.001). A latency reduction was also observed for wave III (mean pre=4.40 ms; mean post=4.13 ms; pG0.001). These reductions in response latency are consistent with functional changes including disinhibition or/and more rapid intra-cellular signalling affecting binaurally sensitive neurons in the central auditory system. The results are highly relevant for improved understanding of putative physiological mechanisms underlying perceptual disorders such as tinnitus and hyperacusis.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid Increase in Neural Conduction Time in the Adult Human Auditory Brainstem Following Sudden Unilateral Deafness

Maslin

Lloyd

Rutherford

et al. 2015

JARO

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“…One key feature of the central auditory system is that the information conveyed through neuronal activity to either of the two auditory cortices is comprised of information processed on multiple levels and integrated from both ears (guinea pig, Rutkowski et al 2000;cat, Reale and Brugge 1990;and macaque, Reser et al 2000). Regarding signal processing, a functional dominance of the afferent pathway to the contralateral cortex was shown (guinea pig, Popelar et al 1994;primate, Heffner and Heffner 1989;and human, Woldorff et al 1999;Jäncke et al 2002;Schönwiesner et al 2007) that benefits a faster and stronger cortical activation of the contralateral ear's input (Hall and Goldstein 1968;Majkowski et al 1971). Thus, in the dichotic s/n condition, the activation generated in the auditory cortex of either hemisphere differs-in the cortex contralateral to the ear where the signals are presented the representation of the signal input predominates the noise input, while in the other cortex the respective weighting is reversed.…”

Section: Auditory Impairmentsmentioning

confidence: 99%

“…Unlike in other sensory systems, most fibers ascending from either auditory thalamus to the ipsilateral auditory cortex convey binaural input (guinea pig, Rutkowski et al 2000;cat, Rosenzweig 1951;Morel and Imig 1987;and human, Celesia 1976) due to multiple ipsilateral and contralateral convergence in the auditory brainstem (Moore and Osen 1979;Nieuwenhuys 1984;Moore 1987;Bazwinsky et al 2003). Still, there is evidence for a functional dominance of the connections from either ear to the contralateral auditory cortex (guinea pig, Popelar et al 1994;nonhuman primates, Heffner and Heffner 1989;and human, Celesia 1976;Woldorff et al 1999;Jäncke et al 2002) leading to stronger and faster cortical activation mediated by the information from the contralateral ear (Hall and Goldstein 1968;Majkowski et al 1971). Due to such multiple binaural convergences, hemisphere-specific testing of auditory structures is impossible using monaural tests, with signals being presented to one ear or even by the use of binaural tests, where identical stimuli are presented to both ears at the same time.…”

Section: Introductionmentioning

confidence: 99%

Auditory Processing Disorders with and without Central Auditory Discrimination Deficits

Ludwig

Fuchs

Kruse

et al. 2014

JARO

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Auditory processing disorder (APD) is defined as a processing deficit in the auditory modality and spans multiple processes. To date, APD diagnosis is mostly based on the utilization of speech material. Adequate nonspeech tests that allow differentiation between an actual central hearing disorder and related disorders such as specific language impairments are still not adequately available. In the present study, 84 children between 6 and 17 years of age (clinical group), referred to three audiological centers for APD diagnosis, were evaluated with standard audiological tests and additional auditory discrimination tests. Latter tests assessed the processing of basic acoustic features at two different stages of the ascending central auditory system: (1) auditory brainstem processing was evaluated by quantifying interaural frequency, level, and signal duration discrimination (interaural tests). (2) Diencephalic/telencephalic processing was assessed by varying the same acoustic parameters (plus signals with sinusoidal amplitude modulation), but presenting the test signals in conjunction with noise pulses to the contralateral ear (dichotic signal/ noise tests). Data of children in the clinical group were referenced to normative data obtained from more than 300 normally developing healthy school children. The results in the audiological and the discrimination tests diverged widely. Of the 39 children that were diagnosed with APD in the audiological clinic, 30 had deficits in auditory performance. Even more alarming was the fact that of the 45 children with a negative APD diagnosis, 32 showed clear signs of a central hearing deficit. Based on these results, we suggest revising current diagnostic procedure to evaluate APD in order to more clearly differentiate between central auditory processing deficits and higher-order (cognitive and/or language) processing deficits.

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Tonotopic cortical changes following stapes substitution in otosclerotic patients: A magnetoencephalographic study

Tecchio¹,

Bicciolo²,

Campora³

et al. 2000

Hum. Brain Mapp.

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The aim of the study was to investigate and follow up the tonotopic organization of the primary auditory cortex in otosclerotic patients before and after corrective surgery. The characteristics of primary auditory cortex activation were studied in ten otosclerotic patients (i.e., subjects suffering from a conductive hearing loss, prior to and following stapes substitution). Magnetoencephalographic recordings of auditory evoked fields by tone-burst stimulation at octave frequencies between 250 and 2000 Hz were performed during monaural stimulation. The brain topography of the main cortical response (N100m) generators at different tones was studied in patients and compared with ten healthy controls; pre- post-surgical changes were also correlated to their clinical outcome following corrective surgery. A significant decrease of the tonotopic extension in the cortical region responsive to the four explored frequencies was found in patients before surgery with respect to the control population. At the time of postsurgical follow-up, the tonotopic representation had enlarged and was approaching the dimensions seen in normal subjects, although with higher variability. The extent of the enlargement of the postoperative tonotopically organized area was directly correlated with the postsurgery period duration. Our findings indicate that auditory cortical areas of human adults undergo functional reorganization following peripheral alteration of the sensory input entering the CNS. The restriction of the cortical tonotopic region caused by the long-term reduction of acoustic input is followed by a reorganization within the usual boundaries following the recovery of auditory function; this process is taking place in a time scale of a few weeks.

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Plastic changes in ipsi-contralateral differences of auditory cortex and inferior colliculus evoked potentials after injury to one ear in the adult guinea pig

Cited by 102 publications

References 42 publications

Rapid Increase in Neural Conduction Time in the Adult Human Auditory Brainstem Following Sudden Unilateral Deafness

Rapid Increase in Neural Conduction Time in the Adult Human Auditory Brainstem Following Sudden Unilateral Deafness

Auditory Processing Disorders with and without Central Auditory Discrimination Deficits

Tonotopic cortical changes following stapes substitution in otosclerotic patients: A magnetoencephalographic study

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