Plastic mulch film is widely used in agricultural production. However, there are very few studies on degradable mulch film. In order to investigate the effects of using degradable mulch film in arid regions on crop yield and water use efficiency, we used fully biodegradable mulch films on both maize and bare land cultivation experimental areas. The DeNitrification-DeComposition (DNDC) model was used to analyze changes in maize biomass in the future under different climate scenario models. We found that using fully biodegradable mulch film in an arid region had a positive effect on biomass yields. In 2015-2017, the annual maize biomass yield increased by 24.5%, 28.9%, and 32.9%, respectively. Hence, this method has expansion and promotion value. A comparison of the DNDC model simulated biomass yields and actual measured values found that the ranges of R2, root mean square error (RMSE), and model efficiency (ME) were 0.98-0.99, 0.38-0.86 mg C ha −1 , and 0.80-0.98. This result shows that the DNDC model can accurately simulate changes in maize biomass in this region. Under the premise of a good model fit, future climate scenario model data were used to drive the DNDC model. The results showed that the possible range of maize biomass yields in the future is −6.5% to 10.3%, with the most probable range being 0.2-1.5%. Using future climatic conditions, our work suggests that degradable mulch films can increase water use efficiency by an average of 9.5%. The results of this study can be used to promote the use of degradable mulch films in arid regions, significantly improving sustainable agricultural development.