Plastic leachate exposure drives antibiotic resistance and virulence in marine bacterial communities

Vlaanderen, Eric J; Ghaly, Timothy M.; Moore, Lisa R.; Focardi, Amaranta; Paulsen, Ian T.; Tetu, Sasha

doi:10.1016/j.envpol.2023.121558

Cited by 16 publications

(9 citation statements)

References 79 publications

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“…An important study by Zhou et al [14 & ] showed increased AMR in the setting of multiple environmental factors including temperature, precipitation, and air quality measured by particulate matter (PM) 2.5, along with population density, governance, antibiotic use, and access to basic drinking water services. Zhou et al [14 ] found that PM 2.5 did associate with, and perhaps even drove, AMR patterns across the globe.…”

Section: Climate Change and Environmental Drivers Of Antimicrobial Re...mentioning

confidence: 99%

“…Researchers cultured seawater samples with differing concentrations of PVC leachate versus controls, and found that PVC-enriched seawater cultures significantly increased ARG presence. Furthermore, the seawater cultures with PVC leachate had more ARGs for efflux pumps which could work broadly across antimicrobial classes [19 ▪ ]. Another study by Liang et al [20] found that microplastics in Spanish coastal waters were enriched with fecal indicator bacteria and ARGs compared to bacterial communities in the water itself.…”

Section: Introductionmentioning

confidence: 99%

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Climate change and resilience for antimicrobial stewardship and infection prevention

Abeles,

Kline,

Lee

2024

Current Opinion in Infectious Diseases

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Purpose of review This review covers recent research regarding the challenges posed by climate change within the areas of antimicrobial stewardship and infection prevention, and ways to build resiliency in these fields. Recent findings Infectious disease patterns are changing as microbes adapt to climate change and changing environmental factors. Capacity for testing and treating infectious diseases is challenged by newly emerging diseases, which exacerbate challenges to antimicrobial stewardship and infection prevention. Antimicrobial resistance is accelerated due to environmental factors including air pollution, plastic pollution, and chemicals used in food systems, which are all impacted by climate change. Climate change places infection prevention practices at risk in many ways including from major weather events, increased risk of epidemics, and societal disruptions causing conditions that can overwhelm health systems. Researchers are building resilience by advancing rapid diagnostics and disease modeling, and identifying highly reliable versus low efficiency interventions. Summary Climate change and associated major weather and socioeconomic events will place significant strain on healthcare facilities. Work being done to advance rapid diagnostics, build supply chain resilience, improve predictive disease modeling and surveillance, and identify high reliability versus low yield interventions will help build resiliency in antimicrobial stewardship and infection prevention for escalating challenges due to climate change.

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Section: Climate Change and Environmental Drivers Of Antimicrobial Re...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Climate change and resilience for antimicrobial stewardship and infection prevention

Abeles,

Kline,

Lee

2024

Current Opinion in Infectious Diseases

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“…However, they may exhibit a high probability of yielding false-negative or false-positive results when used against environmental bacterial strains [14]. Thus, while preliminary screening and identification can be conducted via biochemical methods, the validation of results necessitates molecular-based techniques [15,16]. Consequently, strains biochemically identified as various species of Staphylococci were reclassified as Exiguobacterium and Lysinibacillus species, underscoring the importance of 16S rDNA sequencing in mitigating any potential false-positive outcome.…”

Section: Isolation Of Targeted Bacteriamentioning

confidence: 99%

Emerging Issues on Antibiotic-Resistant Bacteria Colonizing Plastic Waste in Aquatic Ecosystems

Ferheen,

Spurio,

Marcheggiani

2024

Antibiotics

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Antibiotic-resistant bacteria (ARB) adhesion onto plastic substrates is a potential threat to environmental and human health. This current research investigates the prevalence of two relevant human pathogens, Staphylococcus spp. and Klebsiella spp., and their sophisticated equipment of antibiotic-resistant genes (ARGs), retrieved from plastic substrates submerged into an inland water body. The results of microbiological analysis on selective and chromogenic media revealed the presence of colonies with distinctive phenotypes, which were identified using biochemical and molecular methods. 16S rDNA sequencing and BLAST analysis confirmed the presence of Klebsiella spp., while in the case of Staphylococcus spp., 63.6% of strains were found to be members of Lysinibacillus spp., and the remaining 36.3% were identified as Exiguobacterium acetylicum. The Kirby–Bauer disc diffusion assay was performed to test the susceptibility of the isolates to nine commercially available antibiotics, while the genotypic resistant profile was determined for two genes of class 1 integrons and eighteen ARGs belonging to different classes of antibiotics. All isolated bacteria displayed a high prevalence of resistance against all tested antibiotics. These findings provide insights into the emerging risks linked to colonization by potential human opportunistic pathogens on plastic waste commonly found in aquatic ecosystems.

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“…The rapid growth of modern industry has led to a surge in polystyrene plastic packaging, yet inadequate management practices have resulted in severe global environmental repercussions [1][2][3][4][5]. According to the United Nations Environment Programme, single-use plastics and polystyrene foam are consistently among the top ten contributors to marine pollution, with over eight million tons of plastic entering the oceans annually [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Utilizing Recycled Expanded Polystyrene Plastics to Stabilize Metal–Organic Frameworks for Heterogeneous Catalysis

Yin,

Shen,

Liang

et al. 2024

Processes

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Polystyrene plastics present significant environmental and human health threats due to their poor recyclability and degradability. However, leveraging their properties to enhance material performance stands out as one of the most effective strategies for mitigating these issues. Here, we have employed recycled expanded polystyrene plastics to manufacture metal–organic framework/expanded polystyrene plastic composites (MOF@EPP) using an adverse solvent precipitation method. This method simultaneously recycles EPPs and safeguards moisture-sensitive MOFs. Due to the exceptional hydrophobic properties of EPPs, HKUST−1@EPP can maintain structural integrity even when immersed in water for 30 days. This method is applicable to other moisture-sensitive MOFs, such as MOF−74(Zn) and MIL−53(Al). The HKUST−1@EPP composite also exhibits desirable heterogeneous catalytic activity in the Knoevenagel condensation reaction between benzaldehyde and acrylonitrile. The conversion rate can reach 94.9% within 4 h at 90 °C and does not exhibit a significant decrease even after six cycles, even in the presence of water. This study not only introduces a novel concept for recycling polystyrene plastics, but also offers a practical strategy for safeguarding moisture-sensitive MOFs.

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Plastic leachate exposure drives antibiotic resistance and virulence in marine bacterial communities

Cited by 16 publications

References 79 publications

Climate change and resilience for antimicrobial stewardship and infection prevention

Climate change and resilience for antimicrobial stewardship and infection prevention

Emerging Issues on Antibiotic-Resistant Bacteria Colonizing Plastic Waste in Aquatic Ecosystems

Utilizing Recycled Expanded Polystyrene Plastics to Stabilize Metal–Organic Frameworks for Heterogeneous Catalysis

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